Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study

Dobrowolski, Piotr; Januszewicz, Magdalena; Witowicz, H.; Warchoł-Celińska, Ewa; Klisiewicz, Anna; Skrzypczyńska-Banasik, Urszula; Kabat, Marek; Kowalczyk, Katarzyna; Aniszczuk-Hybiak, Anna; Florczak, Elżbieta; Witkowski, Adam; Tykarski, Andrzej; Widecka, Krystyna; Szczerbo-Trojanowska, Małgorzata; Śmigielski, Witold; Drygas, Wojciech; Michałowska, Ilona; Hoffmań, Piotr; Prejbisz, Aleksander; Januszewicz, Andrzej

doi:10.1080/08037051.2018.1514252

Cited by 7 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Contrasting with these 2 studies, Dobrowolski et al showed that the proportion of ever smokers did not differ in patients with FMD as compared to the control groups including both general population and subjects with hypertension from general population (Figure 5). Moreover, smoking was neither associated with clinical characteristics of FMD patients nor with extent of FMD nor vascular complications 73 . In summary, data linking smoking with the pathogenesis of FMD are equivocal and further studies are needed to elucidate this potential relationship.…”

Section: New and Revisited Risk Factors For Fmdmentioning

confidence: 79%

Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia

Persu

Dobrowolski

Gornik

et al. 2021

Cardiovascular Research

Self Cite

View full text Add to dashboard Cite

Fibromuscular dysplasia (FMD) is a non-atherosclerotic vascular disease that may involve medium-sized muscular arteries throughout the body. The majority of FMD patients are women. Although a variety of genetic, mechanical, and hormonal factors play a role in the pathogenesis of FMD, overall, its cause remains poorly understood. It is probable that the pathogenesis of FMD is linked to a combination of genetic and environmental factors. Extensive studies have correlated the arterial lesions of FMD to histopathological findings of arterial fibrosis, cellular hyperplasia, and distortion of the abnormal architecture of the arterial wall. More recently, the vascular phenotype of lesions associated with FMD has been expanded to include arterial aneurysms, dissections, and tortuosity. However, in the absence of a string of beads or focal stenosis, these lesions do not suffice to establish the diagnosis. While FMD most commonly involves renal and cerebrovascular arteries, involvement of most arteries throughout the body has been reported. Increasing evidence highlights that FMD is a systemic arterial disease and that subclinical alterations can be found in non-affected arterial segments. Recent significant progress in FMD-related research which has led to improved understandings of the disease’s clinical manifestations, natural history, epidemiology, and genetics. Ongoing work continues to focus on FMD genetics and proteomics, physiological effects of FMD on cardiovascular structure and function, and novel imaging modalities and blood-based biomarkers that can be used to identify subclinical FMD. It is also hoped that the next decade will bring the development of multi-centred and potentially international clinical trials to provide comparative effectiveness data to inform the optimal management of patients with FMD.

show abstract

Section: New and Revisited Risk Factors For Fmdmentioning

confidence: 79%

Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia

Persu

Dobrowolski

Gornik

et al. 2021

Cardiovascular Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Besides the known health-related benefits in the general population, patients with FMD who smoke reportedly have a more progressive and severe disease than non-smokers [22,23]. However, this association was not confirmed in the ARCADIA-POL study [51].…”

Section: Treatmentmentioning

confidence: 99%

Fibromuscular dysplasia: its various phenotypes in everyday practice in 2021

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Data from the US Registry for FMD suggest that cigarette smoking may be associated with higher prevalence of aneurysm among those with FMD 60 ; however, smoking was not a predictor of the presence of aneurysm in a multivariate analysis of the large European FMD Registry 3 or the ARCADIA-POL study (Assessment of Renal and Cervical Artery Dysplasia-Poland). 59 The initiating events of fibroplasia are unknown and hypothesized to be both genetic and nongenetic, possibly relating to several mechanisms that are unlikely to be assessed in end-stage tissue removed at the time of surgical intervention. These include (1) mechanical stretch of the artery, as the sites of arterial involvement such as the renal and carotid arteries are at locations of stretch with movement or positional change, with vascular injury that would promote phenotypic switching of arterial medial smooth muscle cells (SMCs) to a fibroproliferative phenotype; (2) hormonal milieu, invoked as related to the disproportionate burden of disease in women and the occurrence of some vascular events at times of hormonal changes, such as peripartum and perimenopause; and (3) potential infectious etiologies 61 for which data are limited or other causes that have not yet been considered.…”

Section: Clinical Associations and Etiologic Hypotheses Fibromuscular...mentioning

confidence: 99%

“…This relationship between smoking and the development of FMD has not been replicated, and a recent case-control study of 190 patients with FMD and 994 matched controls from the general population did not show any difference in the rates of smoking between the two cohorts. 59 There have also been conflicting data with regard to the association of smoking and rates of aneurysm. Data from the US Registry for FMD suggest that cigarette smoking may be associated with higher prevalence of aneurysm among those with FMD 60 ; however, smoking was not a predictor of the presence of aneurysm in a multivariate analysis of the large European FMD Registry 3 or the ARCADIA-POL study (Assessment of Renal and Cervical Artery Dysplasia-Poland).…”

Section: Clinical Associations and Etiologic Hypothesesmentioning

confidence: 99%

Section: Clinical Associations and Etiologic Hypothesesmentioning

confidence: 99%

See 1 more Smart Citation

FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy

Kim

Saw

Kadian-Dodov

et al. 2021

Circulation Research

View full text Add to dashboard Cite

Multifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. Traditionally known in the context of renovascular hypertension, recent advances in knowledge about FMD have demonstrated that FMD is a systemic arteriopathy presenting as arterial stenosis, aneurysm, and dissection in virtually any arterial bed. FMD is also characterized by major cardiovascular presentations including hypertension, stroke, and myocardial infarction. Similar to FMD, spontaneous coronary artery dissection is associated with a high prevalence of extracoronary vascular abnormalities, including FMD, aneurysm, and extracoronary dissection, and recent studies have also found genetic associations between the two diseases. This review will summarize the relationship between FMD and spontaneous coronary artery dissection with a focus on common clinical associations, histopathologic mechanisms, genetic susceptibilities, and the biology of these diseases. The current status of disease models and critical future research directions will also be addressed.

show abstract

Prevalence of smoking and clinical characteristics in fibromuscular dysplasia. The ARCADIA-POL study

Cited by 7 publications

References 20 publications

Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia

Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia

Fibromuscular dysplasia: its various phenotypes in everyday practice in 2021

FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy

Contact Info

Product

Resources

About