“…In advanced cases, on the other hand, malnourishment and low BMI pose a serious threat to overall health and can have negative effects on tumor therapy (39,40). Tobacco smoking can be associated with low socioeconomic status and higher BMI but also coincided with lower BMI in other studies (41)(42)(43). A poor diet, low in fruit and vegetables, has been correlated with oral cancer, and it has been shown that a Mediterranean diet favorably affects the risk of upper aerodigestive tract cancer (44,45).…”