Prevalence of Sleep Disturbances in Mild Cognitive Impairment and Dementing Disorders: A Multicenter Italian Clinical Cross-Sectional Study on 431 Patients

Guarnieri, Biancamaria; Adorni, Fulvio; Musicco, Massimo; Appollonio, Ildebrando; Bonanni, Enrica; Caffarra, Paolo; Caltagirone, Carlo; Cerroni, Gianluigi; Concari, Letizia; Cosentino, F.; Ferrara, Salvatore; Fermi, Silvia; Ferri, Raffaele; Gelosa, Giorgio; Lombardi, Gemma; Mazzei, Debora; Mearelli, S.; Morrone, Elisa; Murri, Luigi; Nobili, Flavio; Passero, S.; Perri, Roberta; Rocchi, Raffaele; Sucapane, Patrizia; Tognoni, Gloria; Zabberoni, Silvia; Sorbi, Sandro

doi:10.1159/000335363

Cited by 281 publications

(256 citation statements)

References 90 publications

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“…Besides sleep disruption, clinical sleep disorders are strongly comorbid with mild cognitive impairment (MCI) and AD. Over 60% of persons with MCI and AD have one or more sleep disturbances (Ancoli‐Israel, Klauber, Butters, Parker, & Kripke, 1991; Guarnieri et al, 2012), with sleep apnea and insomnia being most common.…”

Section: Lifestyle Associations and Interventions For Aging And Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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Alzheimer's disease is the most prevalent cause of dementia, which is defined by the combined presence of amyloid and tau, but researchers are gradually moving away from the simple assumption of linear causality proposed by the original amyloid hypothesis. Aging is the main risk factor for Alzheimer's disease that cannot be explained by amyloid hypothesis. To evaluate how aging and Alzheimer's disease are intrinsically interwoven with each other, we review and summarize evidence from molecular, cellular, and system level. In particular, we focus on study designs, treatments, or interventions in Alzheimer's disease that could also be insightful in aging and vice versa.

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Section: Lifestyle Associations and Interventions For Aging And Admentioning

confidence: 99%

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

et al. 2018

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“…Furthermore, increased wakefulness and a reduction in NREM sleep of the PLB2 Tau mice rule out increased sleep time as the reason for reduced exploratory activity. In this respect, PLB2 Tau mice present a highly FTD relevant phenotype as sleep disturbances are common in all dementias (Guarnieri et al, 2012), with reduced sleep duration commonly reported in FTD cases (Bombois et al, 2010;Bonakis et al, 2014).…”

Section: Emotional Phenotypes Of Plb2 Tau Micementioning

confidence: 99%

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology

Koss

Robinson

Drever

et al. 2016

Neurobiology of Disease

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Models of Tau pathology related to frontotemporal dementia (FTD) are essential to determine underlying neurodegenerative pathologies and resulting Tauopathy relevant behavioural changes. However, existing models are often limited in their translational value due to Tau overexpression, and the frequent occurrence of motor deficits which prevent comprehensive behavioural assessments. In order to address these limitations, a forebrain-specific (CaMKIIα promoter), human mutated Tau (hTauP301L+R406W) knock-in mouse was generated out of the previously characterised PLB1Triple mouse, and named PLB2Tau. After confirmation of an additional hTau species (~60 kDa) in forebrain samples, we identified age-dependent progressive Tau phosphorylation which coincided with the emergence of FTD relevant behavioural traits. In line with the noncognitive symptomatology of FTD, PLB2Tau mice demonstrated early emerging (~ 6 months) phenotypes of heightened anxiety in the elevated plus maze, depressive/apathetic behaviour in a sucrose preference test and generally reduced exploratory activity in the absence of motor impairments. Investigations of cognitive performance indicated prominent dysfunctions in semantic memory, as assessed by social transmission of food preference, and in behavioural flexibility during spatial reversal learning in a homecage corner-learning task. Spatial learning was only mildly affected and task-specific, with impairments at 12-month of age in the corner learning but not in the water maze task. Electroencephalographic (EEG) investigations indicated a vigilance-stage specific loss of alpha power during wakefulness at both parietal and prefrontal recording sites, and site-specific EEG changes during nonrapid eye movement sleep (prefrontal) and rapid eye movement sleep (parietal). Further investigation of hippocampal electrophysiology conducted in slice preparations indicated a modest reduction in efficacy of synaptic transmission in the absence of altered synaptic plasticity. Together, our data demonstrate that the transgenic PLB2Tau mouse model presents with striking behavioural and physiological face validity relevant for FTD, driven by the low level expression of mutant FTD hTau. AbstractModels of Tau pathology related to frontotemporal dementia (FTD) are essential to determine underlying neurodegenerative pathologies and resulting Tauopathy relevant behavioural changes. However, existing models are often limited in their translational value due to Tau overexpression, and the frequent occurrence of motor deficits which prevent comprehensive behavioural assessments. In order to address these limitations, a forebrain-specific (CaMKIIα promoter), human mutated Tau (hTau P301L+R406W ) knock-in mouse was generated out of the previously characterised PLB1 Triple mouse, and named PLB2 Tau . After confirmation of an additional hTau species (~60 kDa) in forebrain samples, we identified age-dependent progressive Tau phosphorylation which was coincided with the emergence of FTD relevant behavioural traits. In...

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“…O tamanho das amostras foi de 23 a 431 participantes 13,14 . Em relação à causa de demência, houve grandes diferenças entre os estudos.…”

Section: Resultsunclassified

“…A maioria dos estudos que determinou a prevalência de SPI utilizou os critérios do International RLS Study group para o diagnóstico 3,[12][13][14]16 . Em relação ao desenho do estudo, apenas um estudo era longitudinal 12 e os demais eram transversais 3,4,[13][14][15][16] . Três estudos utilizaram idosos saudáveis como grupo controle e também podem ser classificados como caso-controle 4,15,16 .…”

Section: Resultsunclassified

Prevalência de síndrome das pernas inquietas em pacientes com demência: uma atualização

Ribeiro

Novaes

Faleiros

et al. 2016

J. bras. psiquiatr.

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RESUMOObjetivo: Realizar uma revisão atualizada para avaliar a prevalência de síndrome das pernas inquietas e/ou movimentos periódicos dos membros em pacientes com demência, além de discutir dados sobre possíveis fatores de risco desses transtornos. Métodos: A revisão foi realizada utilizando a base de dados do PubMed, com o seguinte cruzamento de descritores: (dementia, Alzheimer's disease, dementia with Lewy's body or frontotemporal dementia) e (restless legs syndrome or periodic leg movements). Resultados: Foram selecionados sete artigos, os quais encontraram prevalência de síndrome das pernas inquietas, que variou de 4% a 24% em idosos com demência. Houve diferenças importantes entre os métodos utilizados para o diagnóstico, tamanho das amostras e causas de demência estudadas. Conclusão: Mais estudos com o objetivo de refinar os critérios diagnósticos e definir fatores de risco, especialmente relacionadas a idosos com demência, são necessários. Além disso, deve-se ficar atento a essa comorbidade na prática clínica. ABSTRACTObjective: To perform an updated review to assess the prevalence of restless legs syndrome and/or periodic limb movements in patients with dementia, besides the discussion about possible risk factors of these disorders. Methods: A review was performed using the PubMed database, crossing the following descriptors: (dementia, Alzheimer's disease, dementia with Lewy's body or frontotemporal dementia) and (restless legs syndrome or periodic leg movements). Results: We selected seven articles according to the inclusion and exclusion criteria. The prevalence of restless legs syndrome in elderly patients with dementia ranged from 4% to 24%. There were important differences in the method used to diagnose, sample size and causes of dementia. Conclusion: More studies are necessary to refine the diagnostic criteria and to define risk factors, especially related to elderly patients with dementia. In addition, the health professionals need to pay attention to this comorbidity in clinical practice.

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Prevalence of Sleep Disturbances in Mild Cognitive Impairment and Dementing Disorders: A Multicenter Italian Clinical Cross-Sectional Study on 431 Patients

Cited by 281 publications

References 90 publications

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Aging and Alzheimer’s disease: Comparison and associations from molecular to system level

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology

Prevalência de síndrome das pernas inquietas em pacientes com demência: uma atualização

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