Prevalence of Sleep Disturbance in Patients With Cancer: A Systematic Review and Meta-Analysis

Maqbali, Mohammed Al; Sinani, Mohammed Al; Alsayed, Ahmad R.; Gleason, Alexander M

doi:10.1177/10547738221092146

Cited by 48 publications

(37 citation statements)

References 122 publications

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“…According to the PSQI scale, 58.6% of the study subjects had sleep problems, and the rate of moderate‐to‐severe insomnia was approximately 26%. This is in line with a recent systematic review about sleep trouble in cancer settings that exhibited an overall figure of 60.7% 33 . Our study also presented a mean global PSQI score of 7.5, which is equivalent to a mild level of sleep disorder.…”

Section: Discussionsupporting

confidence: 91%

A cross‐sectional study of sleep disturbance among middle‐aged cancer patients at Vietnam National Cancer Hospital

Pham,

Do,

Tran

2024

Cancer Reports

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AimSleep disorders are common in cancer patients and have negative consequences for patient well‐being and treatment outcomes. This study aimed to investigate sleep quality and related factors in Vietnamese middle‐aged cancer patients.MethodsA cross‐sectional study was conducted on 246 middle‐aged in‐patient cancer patients at Vietnam National Cancer Hospital (VNCH) from 1/2021 to 7/2021. Sleep was measured by the Pittsburgh Sleep Quality Index (PSQI), with a cutoff of 5.ResultsThe results showed a male/female ratio of 0.85 with an average age of 52. The five most prevalent cancer types were breast, colorectal, lung, and esophagus‐stomach cancer, primarily in the late stage and treated with chemotherapy. The prevalence of sleep disturbances was 58.5%. The mean PSQI score was 7.5, with sleep duration and latency of 5.4 h and 1 h, respectively. Approximately 44% of participants reported poor sleep quality, nearly 9% had daytime dysfunction, and 10.6% used sleep medication. The multivariate logistic regression results indicate that people with depression were 8.89 times more likely to have poor sleep than those without depression (95% CI:2.63–28.27, p < .001).ConclusionSleep problems are common among middle‐aged people with cancer in Vietnam, especially individuals with depression. It is necessary to have more effective approaches to sleep management for cancer patients with limited resources.

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Section: Discussionsupporting

confidence: 91%

A cross‐sectional study of sleep disturbance among middle‐aged cancer patients at Vietnam National Cancer Hospital

Pham,

Do,

Tran

2024

Cancer Reports

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“…Across the three LPAs, regardless of class membership, 75.5%–89.8% of the patients reported GSDS scores above the clinically meaningful cutpoint. These occurrence rates are higher than the 60.7% reported in a meta‐analysis of sleep disturbance in patients with cancer 102 . During sleep, changes occur in respiratory muscle function and ventilatory control 103 .…”

Section: Discussionmentioning

confidence: 72%

Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients

Shin,

Hammer,

Cooley

et al. 2024

Cancer Medicine

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BackgroundShortness of breath occurs in 10%–70% of oncology patients. Very little is known about interindividual variability in its severity and distress and associated risk factors. Using latent profile analyses (LPAs), purpose was to identify subgroups of patients with distinct severity and distress profiles for shortness of breath as single symptom dimensions. In addition, a joint LPA was done using patients' severity AND distress ratings. For each of the three LPAs, differences among the shortness of breath classes in demographic, clinical, symptom, stress, and resilience characteristics were evaluated.MethodsPatients completed ratings of severity and distress from shortness of breath a total of six times over two cycles of chemotherapy. All of the other measures were completed at enrollment (i.e., prior to the second or third cycle of chemotherapy). Separate LPAs were done using ratings of severity and distress, as well as a joint analysis using severity AND distress ratings. Differences among the latent classes were evaluated using parametric and nonparametric tests.ResultsFor severity, two classes were identified (Slight to Moderate [91.6%] and Moderate to Severe [8.4%]). For distress, two classes were identified (A Little Bit to Somewhat [83.9%] and Somewhat to Quite a Bit [16.1%]). For the joint LPA, two classes were identified (Lower Severity and Distress [79.9%] and Higher Severity and Distress [20.1%]). While distinct risk factors were associated with each of the LPAs, across the three LPAs, the common risk factors associated with membership in the worse class included: a past or current history of smoking, poorer functional status, and higher comorbidity burden. In addition, these patients had a higher symptom burden and higher levels of cancer‐specific stress.ConclusionsClinicians can use the information provided in this study to identify high‐risk patients and develop individualized interventions.

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“…Sleep disturbances are prevalent in cancer [ 44 , 45 , 46 , 47 ]. A recent meta-analysis on the prevalence of sleep disturbances in patients with cancer reported an overall prevalence of 60.7%, suggesting that more than half of the cancer patients experience sleep disturbances [ 44 ]. Most importantly, the prevalence was even higher in patients with advanced cancer, with an overall prevalence of 70.8% [ 44 ].…”

Section: Prevalence Of Poor Sleep Qualitymentioning

confidence: 99%

“…A recent meta-analysis on the prevalence of sleep disturbances in patients with cancer reported an overall prevalence of 60.7%, suggesting that more than half of the cancer patients experience sleep disturbances [ 44 ]. Most importantly, the prevalence was even higher in patients with advanced cancer, with an overall prevalence of 70.8% [ 44 ]. Insomnia is considered an underdiagnosed and undertreated health problem in palliative care [ 48 ], as about one third of patients with cancer has insomnia symptoms.…”

Section: Prevalence Of Poor Sleep Qualitymentioning

confidence: 99%

An Update on Prevalence, Assessment, and Risk Factors for Sleep Disturbances in Patients with Advanced Cancer—Implications for Health Care Providers and Clinical Research

Jakobsen

Gjeilo

Hjermstad

et al. 2022

Cancers

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Patients with advanced cancer experience multiple symptoms, with fluctuating intensity and severity during the disease. They use several medications, including opioids, which may affect sleep. Sleep disturbance is common in cancer patients, decreases the tolerability of other symptoms, and impairs quality of life. Despite its high prevalence and negative impact, poor sleep quality often remains unrecognized and undertreated. Given that sleep is an essential aspect of health-related quality of life, it is important to extend both the knowledge base and awareness among health care providers in this field to improve patient care. In this narrative review, we provide recommendations on sleep assessment in patients with advanced cancer and highlight cancer-related factors that contribute to insomnia. We also present direct implications for health care providers working in palliative care and for future research.

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Prevalence of Sleep Disturbance in Patients With Cancer: A Systematic Review and Meta-Analysis

Cited by 48 publications

References 122 publications

A cross‐sectional study of sleep disturbance among middle‐aged cancer patients at Vietnam National Cancer Hospital

A cross‐sectional study of sleep disturbance among middle‐aged cancer patients at Vietnam National Cancer Hospital

Common and distinct risk factors that influence more severe and distressing shortness of breath profiles in oncology outpatients

An Update on Prevalence, Assessment, and Risk Factors for Sleep Disturbances in Patients with Advanced Cancer—Implications for Health Care Providers and Clinical Research

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