Prevalence of Sleep Disorders and Association With Mortality: Results From the <scp>NHANES</scp> 2009–2010

Huyett, Phillip; Siegel, Noah; Bhattacharyya, Neil

doi:10.1002/lary.28900

Cited by 46 publications

(32 citation statements)

References 14 publications

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“…Currently, sleep quality problems have become a more common health problem. Sleep quality problems can cause adverse effects such as drowsiness and fatigue, easily trigger psychological problems such as anxiety and depression, and increase the risk of cardiovascular diseases such as hypertension and coronary heart disease and death [ 29 , 30 , 31 , 32 , 33 ]. Therefore, it is particularly important to develop targeted preventive and intervention measures for non-manual workers in Xinjiang to improve their sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Effects of Work Stress and Period3 Gene Polymorphism and Their Interaction on Sleep Quality of Non-Manual Workers in Xinjiang, China: A Cross-Sectional Study

Wang

Liu

Xie

et al. 2022

IJERPH

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Work stress has been found to be associated with sleep quality in various occupational groups, and genetic factors such as variable number tandem repeat polymorphism in the Period3 (Per3) gene also influence the circadian sleep-wake process. Therefore, the present study aimed to evaluate the sleep quality status of non-manual workers in Xinjiang, China and to analyse the effects of work stress and Per3 gene polymorphism and their interaction on sleep quality. A cluster sampling method was used to randomly select 1700 non-manual workers in Urumqi, Xinjiang. The work stress and sleep quality of these workers were evaluated using the Effort–Reward Imbalance Inventory (ERI) and the Pittsburgh Sleep Quality Index (PSQI). Next, 20% of the questionnaire respondents were randomly selected for genetic polymorphism analysis. The polymerase chain reaction-restriction fragment length polymorphism technique was used to determine Per3 gene polymorphism. The detection rate of sleep quality problems differed between the different work stress groups (p < 0.05), suggesting that non-manual workers with high levels of work stress are more likely to have sleep quality problems. Regression analysis revealed that the Per3 gene (OR = 3.315, 95% CI: 1.672–6.574) was the influencing factor for poor sleep quality after adjusting for confounding factors, such as occupation, length of service, education, and monthly income. Interaction analysis showed that Per34/5,5/5 × high work stress (OR = 2.511, 95% CI: 1.635–3.855) had a higher risk of developing sleep quality problems as compared to Per34/4 × low work stress after adjusting for confounding factors. The structural equation modelling showed no mediating effect between work stress and Per3 gene polymorphism. The results of this study show that both work stress and Per3 gene polymorphism independently affect sleep quality of nonmanual workers from Xinjiang, and the interaction between these two factors may increase the risk of sleep quality problems. Therefore, to improve sleep quality, individuals with genetic susceptibility should avoid or reduce as much as possible self-stimulation by work-related exposures such as high levels of external work stress.

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Section: Discussionmentioning

confidence: 99%

Effects of Work Stress and Period3 Gene Polymorphism and Their Interaction on Sleep Quality of Non-Manual Workers in Xinjiang, China: A Cross-Sectional Study

Wang

Liu

Xie

et al. 2022

IJERPH

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“… 9 Approximately 7.1–9.8% of the population in the United States have been diagnosed with a sleep disorder. 10 , 11 These patients with sleep disorders reportedly have a 1.5-fold higher mortality rate than the general population with no sleep disorders. 11 Therefore, the prevention and treatment of sleep disorders have become important public health issues.…”

Section: Introductionmentioning

confidence: 99%

“… 10 , 11 These patients with sleep disorders reportedly have a 1.5-fold higher mortality rate than the general population with no sleep disorders. 11 Therefore, the prevention and treatment of sleep disorders have become important public health issues. A previous study reported that critically ill patients often suffer from sleep disturbances due to the development of delirium and the use of sedative agents during sepsis treatment.…”

Section: Introductionmentioning

confidence: 99%

Sleep Disorder and Long-Term Mortality Among Sepsis Survivors: A Nationwide Cohort Study in South Korea

Song

Park

2021

NSS

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Background We aimed to investigate the association of sleep disorder diagnosis among sepsis survivors with 5-year all-cause mortality. Methods Using the National Health Insurance Service (NHIS) database of South Korea, we included adult sepsis survivors who were primarily diagnosed with sepsis between 2011 and 2014 and survived for more than one year after diagnosis. The diagnosis of sleep disorders was evaluated using the International Classification of Diseases, 10th revision codes of G47* in the NHIS database. Results In total, 45,826 survivors of sepsis were included in this analysis. Among the sepsis survivors, 2935 (6.4%) were newly diagnosed with a sleep disorder within 1 year after the date of sepsis diagnosis, while 7938 (17.3%) were already diagnosed with sleep disorder before the date of sepsis diagnosis. In the multivariable Cox regression, the risk of 5-year all-cause mortality in the pre- and post-sepsis sleep disorder groups was 1.19-fold (hazard ratio: 1.19, 95% confidence interval: 1.14–1.24; P <0.001) and 1.79-fold (hazard ratio: 1.79, 95% confidence interval: 1.70–1.89; P <0.001) higher than that of the control group. Conclusion A 6.4% of sepsis survivors in South Korea were newly diagnosed with a sleep disorder within 1 year of sepsis diagnosis. Although both pre- and post-sepsis sleep disorders were associated with a higher 5-year all-cause mortality rate, the risk of the 5-year all-cause mortality in the post-sepsis sleep disorder group was higher than that in the pre-sepsis sleep disorder group.

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“…Growing evidence suggest that sleep habits are important, modifiable risk factors for non-communicable diseases [ 2 ] which may significantly impact quality of life and overall health status. Specifically, poor sleep health has been associated with metabolic [ 3 ], endocrine [ 4 ] and psychiatric [ 5 ] diseases, as well as all-cause mortality [ 6 ]. Combined with high treatment-related costs from increased health care utilization [ 7 ], it is therefore concerning that the prevalence of sleep disorders has become epidemic [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial

et al. 2021

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Background Vitamin D has been linked to sleep health in observational studies. Data from randomized controlled trials (RCTs) with vitamin D is scarce. Methods This study presents the results of a secondary analysis of 189 vitamin D insufficient participants (47.1% women) in a previously performed RCT, of which 92 were randomized to vitamin D (100,000 IU (2500 μg) as a bolus dose followed by 20,000 IU (500 μg) per week), and 97 to placebo. At baseline and after 4 months at the end of the study serum 25-hydroxyvitamin D (s-25(OH)D) was measured, and the study questionnaire assessing sleep duration, daytime sleepiness, and symptoms of insomnia, was completed. Results At baseline, mean s-25(OH)D was 35.0 ± 11.8 and 35.5 ± 13.3 nmol/L in the vitamin D and placebo groups, respectively. After four months, we found no statistically significant differences between the intervention groups in any of the assessed sleep outcomes, neither when stratified by sex, nor when performed in subgroups based on baseline or end of study s-25(OH)D level or presence of sleep complaints at baseline. Conclusions We were not able to demonstrate a significant effect of vitamin D supplementation on sleep in this vitamin D insufficient population.

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Prevalence of Sleep Disorders and Association With Mortality: Results From the NHANES 2009–2010

Cited by 46 publications

References 14 publications

Effects of Work Stress and Period3 Gene Polymorphism and Their Interaction on Sleep Quality of Non-Manual Workers in Xinjiang, China: A Cross-Sectional Study

Effects of Work Stress and Period3 Gene Polymorphism and Their Interaction on Sleep Quality of Non-Manual Workers in Xinjiang, China: A Cross-Sectional Study

Sleep Disorder and Long-Term Mortality Among Sepsis Survivors: A Nationwide Cohort Study in South Korea

No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial

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