Objectives-To determine the prevalence and distribution of sleep-disordered breathing and associated correlates in a large cohort of older men using several standardized definitions.
Design-Cross-sectional analyses.Setting-Six U.S. communities.Participants-Polysomnography was performed on 2,911 participants of the Outcomes of Sleep Disorders in Older Men Sleep Study (mean age ± standard deviation 76.38 ± 5.53; body mass index 27.17 ± 3.8 kg/m 2 ).Address correspondence to Reena Mehra, MD, MS, Case Western Reserve University, 11100 Euclid Ave., Cleveland, OH 44106. Email: mehrar@ameritech.net. This work was performed at the San Francisco Coordinating Center, University of California, San Francisco, and Case Western Reserve University.An abstract of this manuscript was presented at the American College of Chest Physicians meeting, Salt Lake City, Utah, October 2006.Author Contributions: Reena Mehra: lead analysis concept and design, lead interpretation of data, and preparation of manuscript. Katie L. Stone: lead study concept and design for cohort, assisted with interpretation of data and preparation of manuscript. Terri Blackwell: analysis and interpretation of data and assistance with manuscript preparation. Sonia Ancoli-Israel: assistance with study concept and design for cohort, interpretation of data, and preparation of manuscript. Thuy-Tien L. Dam and Marcia L. Stefanick: assistance with interpretation of data and preparation of manuscript. Susan Redline: assistance with study concept and design for cohort and this particular analysis, assistance with interpretation of data and preparation of manuscript.Financial Disclosure: The MrOS Study and the ancillary MrOS Sleep Study are supported by the National Institutes of Health. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Institute on Aging, and the National Cancer Institute, under the following grant numbers: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, and M01 RR000334. The National Heart, Lung, and Blood Institute (NHLBI) provides funding for the MrOS Sleep Study "Outcomes of Sleep Disorders in Older Men" under the following grant numbers: R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, and R01 HL070839. Other funding sources include the American Heart Association National Scientist Development Award (0530188N), Association of Subspecialty Professors, CHEST Foundation of the American College of Chest Physicians T. Franklin Williams Geriatric Development Research Award, and K23 HL079114-01A2 from the NHLBI.Sponsor's Role: The funding institutes had no role in the collection, analysis, or interpretation of the data or in the decision to submit the manuscript for publication. Measurements-Three outcomes were assessed: sleep-disordered breathing (respiratory disturbance index ≥15), obstructive apnea (obstructive apnea index ≥5), and central apnea (central apnea index ≥5).
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