Prevalence of Sickle Cell Trait and Rare Hemoglobin Variants in the Metropolitan Washington DC Area

Niu, Xiaomei; Parry, Christian S.; Mason, Angela; Harrison, Barbara; Nouraie, Mehdi; Ammosova, Tatiana; Salomon-Andonie, Juan; O'Neal, Patricia; Taylor, James G.; Nekhai, Sergeï

doi:10.14740/jh603

Cited by 3 publications

(3 citation statements)

References 4 publications

(5 reference statements)

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“…The ethnic-racial discussions that have been raised are extremely important, especially considering the origin of SCD in sub-Saharan Africa (6) and the prevalence of cases of the disease and sickle cell trait in the black population (31) in Brazil. This fact implies a stigma that the disease has developed over a period of just over a hundred years since its first case was discovered.…”

Section: Discussionmentioning

confidence: 99%

Development and Content Validation of an Instrument Covering Care for Pregnant Women with Sickle Cell Disease

Santos,

Ferreira,

Pinto

et al. 2024

Aquichan

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Introduction: The lack of discussions on nursing care for pregnant women with sickle cell disease in Brazil and the urgent need for intervention and improvements in the nursing care provided to these women sparked this study. In addition, validity is an essential attribute for instruments used in research and/or clinical practice. Objective: To develop and validate an instrument covering the care of pregnant women with sickle cell disease. Materials and methods: This is a methodological, content validation study conducted with specialist judges. The instrument was structured with 19 nursing diagnoses that addressed the biological, psychological, and social dimensions, as well as 126 nursing interventions. The Delphi technique was used with the participation of 18 judges. The results were analyzed using the content validity index and a level of agreement above 0.80. Results: Of the 145 items analyzed, 22 (15.17 %) scored a content validity index < 0.80, and the adjustments suggested by the judges were implemented. The instrument’s general content validity index was calculated at 0.87. The instrument reached acceptable content validity parameters, according to the criteria used. Conclusions: The instrument’s potential stands out, and it can be improved through its use as a resource for guiding nursing practices directed to pregnant women with sickle cell disease, both in primary health care and in hospital networks.

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Section: Discussionmentioning

confidence: 99%

Development and Content Validation of an Instrument Covering Care for Pregnant Women with Sickle Cell Disease

Santos,

Ferreira,

Pinto

et al. 2024

Aquichan

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“…1 The most common sickle cell mutation is HbS (Glu6Val substitution in β-globin) followed by HbC mutation (Glu6Lys substitution in β-globin) and prevalence of sickle cell trait (SCT) is 12.5% in Washington, DC (combined HbAS and HbAC). 2 Several previous studies suggest that patients with SCD are less likely to acquire HIV-1 infection and have slower disease progression. [3][4][5] Prevalence of anti-HIV-1 but not HTLV-1 antibodies was low (2.7% versus 7.9%) in SCD patients transfused with blood that was not screened for HIV-1.…”

Section: Introductionmentioning

confidence: 99%

“…Variables in model: NRTI, NNRTI, PI, AGE at visit, Any drug, interaction of genotype with PI 2. Variables in model: NRTI, NNRTI, PI, Any drug, interaction of genotype with NRTI 3.…”

mentioning

confidence: 99%

Restriction of HIV-1 infection in sickle cell trait

et al. 2021

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Patients with Sickle cell disease (SCD) have lower risk for HIV-1 infection. We showed restriction of ex vivo HIV-1 infection in SCD peripheral blood mononuclear cells (PBMCs) that was due, in part, to the upregulation of antiviral, inflammatory and hemolytic factors including heme oxygenase-1 (HO-1). Here, we investigated whether individuals with sickle cell trait (SCT), who develop mild hemolysis, also restrict HIV-1 infection. Ex vivo infection of SCT PBMCs demonstrated ~2-fold reduction of HIV-1 replication and lower levels of HIV-1 reverse transcription products, 2-Long Terminal Repeats (LTR) circles, HIV-1 integration and gag RNA expression. SCT PBMCs had higher HO-1 mRNA and protein levels and reduced ribonucleotide reductase 2 (RNR2) protein levels. HO-1 inhibition by tin porphyrin eliminated ex vivo HIV-1 restriction. Among Howard University clinic recruits, higher levels of HO-1 and RNR2 mRNA and lower HIV-1 env mRNA levels were found in SCT individuals living with HIV-1. To determine the population level effect of SCT on HIV-1 prevalence, we assessed SCT trait among women living with HIV (WLH) in the Women Interagency HIV-1 Study (WIHS). Among WIHS African American participants, prevalence of SCT was lower among women with HIV compared with uninfected women (8.7% vs 14.2%; OR 0.57; 95%CI = 0.36-0.92, p=0.020). WIHS WLH with SCT had higher levels of CD4+/CD8+ ratios over 20 years of follow up (p=0.003) than matched WLH without SCT. Together, our findings suggest that HIV-1 restriction factors including HO-1 and RNR2 might restrict HIV-1 infection among individuals with SCT and limit the pathogenicity of HIV.

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HIV-1 infection in sickle cell disease and sickle cell trait: role of iron and innate response

Nekhai

Kumari

2022

Expert Review of Hematology

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Prevalence of Sickle Cell Trait and Rare Hemoglobin Variants in the Metropolitan Washington DC Area

Cited by 3 publications

References 4 publications

Development and Content Validation of an Instrument Covering Care for Pregnant Women with Sickle Cell Disease

Development and Content Validation of an Instrument Covering Care for Pregnant Women with Sickle Cell Disease

Restriction of HIV-1 infection in sickle cell trait

HIV-1 infection in sickle cell disease and sickle cell trait: role of iron and innate response

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