Prevalence of severe dementia in Finland

Sulkava, Raimo; Wikström, Juhani; Aromaa, Arpo; Raitasalo, Raimo; Lehtinen, Ville; Lahtela, Kari; Palo, J.

doi:10.1212/wnl.35.7.1025

Cited by 213 publications

(99 citation statements)

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“…Consistent with the report of Jorm et al [4], an almost exponential relationship between age and prevalence of AD, which increased significantly with each 5-year increase in age, was also found in this present study. However, Sulkava et al [46] reported that the prevalence of AD was similar among the young elderly (aged 65-74) and increased significantly after 75 years of age. Our study also showed that the prevalence of AD was higher in women than men within the same age category, but there was no significant difference for VD.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the Kungsholmen Project in Sweden, there were no observed sex differences found in AD prevalence among those under the age of 85. Among those over 85, women exhibited a higher prevalence of AD [46]. In the Eurodem pooled analysis of prevalence of dementia, men under 75 years of age had a slightly higher prevalence, while women over the age of 75 had a higher prevalence [47].…”

Section: Discussionmentioning

confidence: 99%

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The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980–2004 studies

Dong¹,

Peng²,

Lin³

et al. 2007

Age and Ageing

118

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Background dementia has been a major public health problem. However, there has not yet been a nationwide investigation or systematic analysis of the prevalence of dementia in China from 1980 to 2004. Objectives the aim of this study was to analyse the prevalence of dementia and its major subtypes [Alzheimer disease (AD), vascular dementia (VD)] among the population aged 60 years and older in China from 1980 to 2004. Methods epidemiological investigations on dementia in China published in journals and covering the period from 1980 to 2004 were identified manually and on-line by using CBMDISK, Chongqing VIP database and CNKI database. Those reported in English journals were identified using MEDLINE. Selected studies had to describe an original study defined by strict screening and diagnostic criteria. The fixed effects model or random effects model was employed according to statistical test for homogeneity. Results twenty-five studies were selected, the statistical information of which was collected for systematic analysis. Our results showed that AD and VD were the two major subtypes of dementia in China, and the pooled prevalence of AD and VD for the population aged 60 years and older was 1.6 and 0.8%, respectively. There was a higher prevalence of AD in the illiterate elderly population (3.2%) than in those who received years of education. The chronological prevalence of AD increased significantly from 1980 to 2004. In southern and northern China, the prevalence of AD was 2.0 and 1.2%, respectively, while VD was 0.6 and 1.1%, respectively. Conclusions in the last 24 years, AD and VD were the two major subtypes of dementia in China. The prevalence of AD may be affected by sex, education, occupation or age. The prevalence of VD, which was higher in northern than in southern China, seems not to be affected by age, sex or education.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980–2004 studies

Dong¹,

Peng²,

Lin³

et al. 2007

Age and Ageing

118

View full text Add to dashboard Cite

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“…Two Finnish studies 1 - 6 showed rates of senile dementia of the Alzheimer type higher than those of vascular dementia. Jorm et al 35 reported from the integration of the literature that the US studies showed no significant difference, whereas many studies from other western countries revealed a higher rate of senile dementia of the Alzheimer type than vascular dementia.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and etiology of dementia in a Japanese community.

Ueda

Kawano

Hasuo

et al. 1992

Stroke

189

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Background and Purpose:We sought to determine the type-specific prevalence of dementia and its risk factors in elderly persons from the Japanese community of Hisayama.Methods: We studied the prevalence of dementia in 887 Hisayama residents (353 men and 534 women) aged 65 years or older (screening rate, 94.6%) using various items of clinical information, neurological examination, and dementia scales. We also studied brain morphology in 50 of 59 determined to have dementia by computed tomography or autopsy during the subsequent 54 -month period. Factors relevant to dementia were compared between 27 patients with vascular dementia and 789 control subjects without dementia in a retrospective fashion.Results: The prevalence rate of dementia among Hisayama residents aged 65 or older was estimated at 6.7%, with a females to males ratio of 1:2. Among 50 cases of dementia in which brain morphology was examined, the frequency of vascular dementia was 56%; this rate was 2.2 times higher than that for senile dementia of the Alzheimer type. Aging, hypertension, electrocardiographic abnormalities, and high hematocrit were significantly (p<0.05) and independently associated with the occurrence of vascular dementia.Conclusions: Prevalence of dementia among the Hisayama residents was relatively identical to that previously reported, but vascular dementia was more predominant Risk factors for vascular dementia were similar to those for lacunar infarcts. Control of hypertension may be a key to reducing dementia among the Japanese population. (Stroke 1992;23:798-803) KEY WORDS • dementia • epidemiology • Japan • risk factors

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“…In normal aging, female and male rat brains also undergo structural and f unctional changes, including loss and retraction of dendrites, spines, and myelin, as well as decreases in the density of receptor proteins and levels of neurotransmitters (Nunzi et al, 1987;Moroi-Fetters et al, 1989;Garcia-Segura et al, 1991). It has been suggested that, in females, memory loss is exacerbated by the decline in gonadal estrogens, marking reproductive senescence (rats) and menopause (humans) (Sulkava et al, 1985;Alliot and Giry, 1991). Conversely, replacement of estrogens protects against decline in memory in normal aging, as well as in Alzheimer's disease K imura, 1995;Henderson et al, 1996;O'Neal et al, 1996;Tang et al, 1996;Henderson, 1997;Kawas et al, 1997;Sherwin, 1997).…”

Section: Abstract: Estrogens; Aging; Alzheimer's Disease; Memory; Dementioning

confidence: 99%

Granule Cells in Aging Rats Are Sexually Dimorphic in Their Response to Estradiol

1999

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Normal aging comprises cognitive decline, including deterioration of memory. It has been suggested that this decline in memory is sexually dimorphic because of the cessation in gonadal steroid secretion that occurs during reproductive aging in female, but not male, mammals. We wondered whether neurons in brain regions associated with learning and memory underwent morphological changes that were dimorphic as well and whether cessation of the secretion of gonadal steroids influenced these morphological changes. To explore these questions, we deprived and restored estrogens to young and old gonadectomized females and males and studied the morphology of dentate granule cells by intracellular dye filling in a lightly fixed slice preparation. We found the following: (1) Aged female dentate granule cells deprived of gonadal steroids longterm have a paucity of dendritic spines compared with young females deprived short-term; however, aged male dentate granule cells deprived of gonadal steroids long-term have no decrease in dendritic spines compared with young males deprived short-term. (2) Aged female dentate granule cells with long-term estrogen replacement at either high or low levels still had a decline in spine density. (3) Aged female dentate granule cells with short-term estradiol replacement had spine density increased to levels normally observed in young adults, whereas aged males with short-term estradiol replacement had decreased spine density. These data suggest that the response of rat dentate granule cells to aging and estradiol is sexually dimorphic and that, in females, the responsiveness of granule cells depends on the temporal pattern of estradiol replacement.

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Prevalence of severe dementia in Finland

Cited by 213 publications

References 0 publications

The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980–2004 studies

The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980–2004 studies

Prevalence and etiology of dementia in a Japanese community.

Granule Cells in Aging Rats Are Sexually Dimorphic in Their Response to Estradiol

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