Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren's syndrome

Terada, Kaoru; Katamine, Shigeru; Moriuchi, Ryozo; Miyamoto, Tsutomu; Eguchi, Katsuyuki; Kita, Masako; Shimada, H; Yamashita, Izumi; Nagataki, Shigenobu; Iwata, Kokichi; Tsuji, Yoshiro

doi:10.1016/s0140-6736(94)90630-0

Cited by 213 publications

(134 citation statements)

References 23 publications

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“…ADF, initially identified in HTLV-I-infected cells of patients with ATL, can be produced in other virusinfected cells (21). We designed primers specific for HTLV-I and HIV (which have been implicated in the pathogenesis of SS [34,35]), in addition to EBV, in a PCR assay to detect viral genes in TRWADF mRNApositive-salivary glands of 8 patients. Despite the detection of increased levels of EBV DNA in TRW ADF mRNA-positive samples, no HTLV-I or HIV was detected ( Figure 4A).…”

Section: Immunohistologic Analysis Of Trwadf-expressing Cells In Ss Smentioning

confidence: 99%

Increased expression of human thioredoxin/adult T cell leukemia–derived factor in Sjögren's syndrome

Shimuta

Terauchi

Tsubota

et al. 1996

Arthritis & Rheumatism

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Objective. To determine the involvement of human thioredoxidadult T cell leukemia-derived factor (TRWADF) in Sjogren's syndrome (SS) and the correlation with Epstein-Barr virus (EBV).Methods. Indirect immunohistochemical techniques and reverse transcriptase polymerase chain reaction were utilized to analyze TRX/ADF expression and the presence of EBV, using 6 normal tissues and 23 surgical specimens. The kinetics of expression of TRW ADF induced by EBV was examined in vitro with peripheral blood B cells from EBV-seronegative donors.Results. Marked expression of TRWADF was found in the infiltrating B cells and the epithelial cells of salivary gland tissues from patients with SS (11 of 12 cases), but not in those from patients with other salivary gland inflammatory conditions (0 of 11 cases) or those of normal individuals (0 of 6 cases). In immunohistologic analyses, a striking topographic correlation between TRWADF and EBV was found. The coexistence of TRWADF messenger RNA and EBV DNA was detected by polymerase chain reaction (r = 0.75, P < 0.01).

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Section: Immunohistologic Analysis Of Trwadf-expressing Cells In Ss Smentioning

confidence: 99%

Increased expression of human thioredoxin/adult T cell leukemia–derived factor in Sjögren's syndrome

Shimuta

Terauchi

Tsubota

et al. 1996

Arthritis & Rheumatism

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“…associated with several inflammatory diseases, such as chronic myelopathy (HTLV-I-associated myelopathyi tropical spastic paraparesis) (2,3), chronic arthritis (HTLV-I-associated arthropathy) (4,5), uveitis (6), and Sjogren's syndrome (7,8). The protein p40taX, which is encoded by the HTLV-I p X region, transactivates not only the viral long terminal repeat, but also a variety of cellular genes, including interleukin-2 (IL-2), IL-2 receptor (IL-2R), and other cytokines (9)(10)(11).…”

mentioning

confidence: 99%

Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice

Fujisawa

Okamoto

Asahara

et al. 1998

Arthritis & Rheumatism

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Objective. To examine T cell clonotypes infiltrating into arthritic joints and to investigate whether human T cell leukemia virus type I (HTLV-I) env-pX gene products act as autoantigens in HTLV-I env-pX transgenic mice.Methods. Complementary DNA (cDNA) encoding the V-D-J (third complementarity-determining region[CDR3]) region of T cell receptor p chain was amplified by Vp family polymerase chain reaction. T cell clonotypes were detected by a single-strand conformational polymorphism method, and sequence analysis of the CDR3 region was performed.Results. Distinct oligoclonal T cell expansion was observed in arthritic joints, and a conserved amino acid motif in the CDR3 region was found in T cells infiltrating joints. Moreover, several intraarticular T cells recognized HTLV-I Env and Tax proteins.Conclusion. Our results suggest that HTLV-I Env and Tax proteins act as autoantigens that are recognized by autoreactive T cells in inflamed arthritic lesions in the HTLV-I env-pX transgenic mouse. Thus, some T cells infiltrating the joint recognize Env or Tax protein. These cells may trigger chronic arthritis in HTLV-I env-pX transgenic mice.Human T cell leukemia virus type I (HTLV-I), the etiologic agent of adult T cell leukemia (1), is also

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“…Serological studies demonstrated the prevalence of antibodies to HTLV in Sjögren patients ranging from 23-36%, significantly higher than that among blood donors. Salivary IgA antibodies to HTLV were found in seropositive HTLV patients with SS (22,23) . Indeed, two independent studies confirmed the presence of HTLV genome in salivary glands samples from patients with Sjögren (24,25) .…”

Section: Htlvmentioning

confidence: 97%

Dry eye disease caused by viral infection: review

Alves¹,

Angerami²,

Rocha³

2013

Arq. Bras. Oftalmol.

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Dry eye disease and ocular surface disorders may be caused or worsened by viral agents. There are several known and suspected virus associated to ocular surface diseases. The possible pathogenic mechanisms for virus-related dry eye disease are presented herein. This review serves to reinforce the importance of ophthalmologists as one of the healthcare professional able to diagnose a potentially large number of infected patients with high prevalent viral agents. Keywords

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Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren's syndrome

Cited by 213 publications

References 23 publications

Increased expression of human thioredoxin/adult T cell leukemia–derived factor in Sjögren's syndrome

Increased expression of human thioredoxin/adult T cell leukemia–derived factor in Sjögren's syndrome

Evidence for autoantigens of Env/Tax proteins in human T cell leukemia virus type I Env-pX transgenic mice

Dry eye disease caused by viral infection: review

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