Prevalence of Sensorineural Hearing Loss in Pediatric Patients with Sickle Cell Disease: A Meta‐analysis

Strum, David P.; Kapoor, Elina; Shim, Timothy; Kim, Sunny; Sabetrasekh, Parisa; Monfared, Ashkan

doi:10.1002/lary.29199

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…Additionally, in disorders such as sickle cell disease and Susac syndrome, microvascular arterial disruption occurs through the "sickling" of red blood cells and endothelial cell disruption, respectively. Given that atherosclerosis [Kim et al, 2020], sickle cell disease [Strum et al, 2021], and Susac syndrome [Kleffner et al, 2016] are associated with hearing loss and vascular eye disease, it is likely that similar vascular processes occur in the ear and eye.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional High-Resolution Temporal Bone Histopathology Identifies Areas of Vascular Vulnerability in the Inner Ear

et al. 2021

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Objectives: Hypothesized causes of vestibular neuritis/labyrinthitis include neuroinflammatory or vascular disorders, yet vascular disorders of the inner ear are poorly understood. Guided by known microvascular diseases of the retina, we developed 2 hypotheses: (1) there exist vascular vulnerabilities of artery channels in cases of hypothetical nerve swelling for the superior, inferior, and vestibulocochlear artery and (2) there are arteriovenous crossings that could compromise vascular flow in disease states. Methods: Two fully mounted and stained temporal bones were used to render three-dimensional reconstructions of the labyrinth blood supply. Using these maps, areas of potential vascular compression were quantified in 50 human temporal bones. Results: Although inner ear arteries and veins mostly travel within their own bony channels, they may be exposed (1) at the entrance into the otic capsule, and (2) where the superior vestibular vein crosses the inferior vestibular artery. At the entry into the otic capsule, the ratio of the soft tissue to total space for the superior vestibular artery was significantly greater than the inferior vestibular artery/cochleovestibular artery (median 44, interquartile range 34–55 vs. 14 [9–17], p < 0.0001). Conclusions: Three-dimensional reconstruction of human temporal bone histopathology can guide vascular studies of the human inner ear. Studies of retinal microvascular disease helped identify areas of vascular vulnerability in cases of hypothetical nerve swelling at the entrance into the otic capsule and at an arteriovenous crossing near the saccular macula. These data may help explain patterns of clinical findings in peripheral vestibular lesions.

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Section: Discussionmentioning

confidence: 99%

Three-Dimensional High-Resolution Temporal Bone Histopathology Identifies Areas of Vascular Vulnerability in the Inner Ear

et al. 2021

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Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Xu,

Liao,

Zhang

et al. 2024

Otolaryngol.--head neck surg.

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ObjectiveWe aimed to investigate the potential environmental risk factors, protective factors, and biomarkers of hearing loss (HL), and establish a hierarchy of evidence.Data SourcesEmbase, PubMed, Cochrane Library, and Web of Science electronic database from inception to June 1, 2023.Review MethodsWe included meta‐analyses of observational studies of associations between HL and environmental risk factors, protective factors, or biomarkers. We calculated summary effect estimates, 95% confidence interval, heterogeneity I2 statistic, 95% prediction interval, small study effects, and excess significance biases.ResultsOf the 9211 articles retrieved, 60 eligible articles were included. The 60 eligible articles identified 47 potential environmental risk and protective factors (N = 4,123,803) and 46 potential biomarkers (N = 173,701). Evidence of association was convincing (class I) for rheumatoid arthritis (RA) and every 1 cm increase in height. Evidence of association was highly suggestive (class II) for human immunodeficiency virus (HIV), diabetes, cumulative noise exposure (CNE), smoking, congenital cytomegalovirus (CMV) infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and alopecia areata (AA).ConclusionIn this umbrella review, RA, every 1 cm increase in height, HIV, diabetes, CNE, smoking, congenital CMV infection, combined exposure to organic solvents and noise, non‐Gaussian noise exposure, each 1 kg increase in birth weight, noise exposure, and AA were strongly associated with HL.

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Brain MRI findings of prelingually deaf children and cochlear implant outcome: Preliminary results

Assiri¹,

Alshalan²,

Alqahtani³

et al. 2022

International Journal of Pediatric Otorhinolaryngology

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Prevalence of Sensorineural Hearing Loss in Pediatric Patients with Sickle Cell Disease: A Meta‐analysis

Cited by 5 publications

References 38 publications

Three-Dimensional High-Resolution Temporal Bone Histopathology Identifies Areas of Vascular Vulnerability in the Inner Ear

Three-Dimensional High-Resolution Temporal Bone Histopathology Identifies Areas of Vascular Vulnerability in the Inner Ear

Environmental Risk Factors, Protective Factors, and Biomarkers for Hearing Loss: An Umbrella Review

Brain MRI findings of prelingually deaf children and cochlear implant outcome: Preliminary results

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