Prevalence of selected viral infections among blood donors deferred for potential risk to blood safety

Zou, Shimian; Fujii, Karen; Johnson, Stephanie T.; Spencer, Bryan R.; Washington, Nicole; Notari, Edward P.; Musavi, Fatemeh; Newman, Bruce; Cable, Ritchard G.; Rios, Jorge A.; Hillyer, Krista L.; Hillyer, Christopher D.; Dodd, Roger Y.

doi:10.1111/j.1537-2995.2006.01008.x

Cited by 26 publications

(28 citation statements)

References 12 publications

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“…This rate was similar to comparable studies: In the literature, about 10-15% of applicant donors are deferred due to the DQ [4][5][6]. Still, in comparison to the established DQ, we found an increase in deferrals by 5.4% and 1.4% in first-time and repeat donations respectively.…”

Section: Discussionsupporting

confidence: 75%

Good Feasibility of the New German Blood Donor Questionnaire

Houareau

Deitenbeck

Sümnig

et al. 2017

Transfus Med Hemother

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Background: We assessed the effect of the uniform donor questionnaire (UDQ) on deferral rates in first-time and repeat donors. We focused on the introduced question about unprotected sexual contact with a new partner. Another goal was a stratified comparison of the deferral rates of the donor questionnaire (DQ) and UDQ. Methods: Data on donors and deferrals using the DQ and UDQ were collected at four blood establishments. The comparison included a 2-year period by questionnaire version. For the comparison of the questionnaires, an adjusted multinomial logistic regression was performed. Results: The analysis included 260,848 donations. First-time (FTD) and repeat donations (RD) showed higher deferral rates with the UDQ (FTD +5.4%, RD +1.4%). Deferral due to a new partner was 3.0% in first-time and 0.4% in repeat donors. The majority of these occurred in the youngest age groups. The most frequent deferral criterion was ‘disease' (5.1%). Conclusion: The regression revealed stronger predictors for deferral than the questionnaire version. Especially younger age carried a higher and independent risk for deferral. The additional deferrals of mainly young first-time donors due to a new sexual partner may identify those donors with potential heterosexual risk behavior who would otherwise not be identified.

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Section: Discussionsupporting

confidence: 75%

Good Feasibility of the New German Blood Donor Questionnaire

Houareau

Deitenbeck

Sümnig

et al. 2017

Transfus Med Hemother

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“…Instead, additional information and education is needed, like in other health‐related disciplines. Such a questionnaire should be updated regularly as questionnaires evaluated periodically have shown to significantly reduce the prevalence of HIV and HCV 35 …”

Section: Discussionmentioning

confidence: 99%

Transfusion safety in francophone African countries: an analysis of strategies for the medical selection of blood donors

et al. 2011

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BACKGROUND The goal of selecting a healthy blood donor is to safeguard donors and reduce the risks of infections and immunologic complications for recipients. STUDY DESIGN AND METHODS To evaluate the blood donor selection process, a survey was conducted in 28 blood transfusion centers located in 15 francophone African countries. Data collected included availability of blood products, risk factors for infection identified among blood donor candidates, the processing of the information collected before blood collection, the review process for the medical history of blood donor candidates, and deferral criteria for donor candidates. RESULTS During the year 2009, participating transfusion centers identified 366,924 blood donor candidates. A mean of 13% (range, 0%–36%) of the donor candidates were excluded based solely on their medical status. The main risk factors for blood-borne infections were having multiple sex partners, sexual intercourse with occasional partners, and religious scarification. Most transfusion centers collected this information verbally instead of having a written questionnaire. The topics least addressed were the possible complications relating to the donation, religious scarifications, and history of sickle cell anemia and hemorrhage. Only three centers recorded the temperature of the blood donors. The deferral criteria least reported were sickle cell anemia, piercing, scarification, and tattoo. CONCLUSIONS The medical selection process was not performed systemically and thoroughly enough, given the regional epidemiologic risks. It is essential to identify the risk factors specific to francophone African countries and modify the current medical history questionnaires to develop a more effective and relevant selection process.

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“…Ideally, there should be an acceptable balance between the costs and impact of preventive measures taken on the one hand, versus the savings and advantages of these measures on the other hand. In the case of the DHQ this balance has not been well studied 9‐13. TTI screening activities were recently reviewed by O'Brien and colleagues .…”

Section: Tti Statistics In the Netherlands1‐5mentioning

confidence: 99%

“…Goldman and coworkers studied the use of the DHQ, examining optimal wordings, formats, and lengths of questions and found room for improvement on these topics. Zou and coworkers studied the prevalence of TTIs in deferred donors. This study, with a 13% enrolment, showed odds ratios of 3.4 to 18.1 for the prevalence of TTIs in donors deferred for high TTI risk such as intravenous (IV) drug use.…”

Section: Tti Statistics In the Netherlands1‐5mentioning

confidence: 99%