Prevalence of Secondary Lymphedema in Patients With Head and Neck Cancer

Deng, Jie; Ridner, Sheila H.; Dietrich, Mary S.; Wells, Nancy; Wallston, Kenneth A.; Sinard, Robert J.; Cmelak, Anthony J.; Murphy, Barbara A.

doi:10.1016/j.jpainsymman.2011.03.019

Cited by 172 publications

(172 citation statements)

References 14 publications

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“…Внутренний отек может быть выявлен только в ре-зультате эндоскопического исследования [9]. По данным литературы, у пациентов с опухолями головы и шеи при нарушении глотания в 30 % случаев обнаружива-ется внутренняя лимфедема [10], которая может на-рушать также функции жевания, дыхания, речи.…”

Section: диагностикаunclassified

“…По данным J. Deng и соавт., обследовавших 84 пациента с лимфедемой после комбинированного лечения опухолей головы и шеи, в 39,4 % случаев лимфедема была изолирован-ной внутренней, в 9,8 % -наружной, а в 50,8 % -ком-бинированной. Отметим, что в том же исследовании только 13,3 % пациентов предъявляли субъективные жалобы на отек головы и 16,7 % -на отек лица [9]. Терапия В настоящее время лимфедема области головы и шеи зачастую остается без внимания.…”

Section: диагностикаunclassified

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Lymphedema after combination treatment of head and neck tumors

et al. 2018

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ВведениеЛимфедема области головы и шеи, как и лимфедемы других локализаций, может быть первичной и вторич-ной. Первичная лимфедема развивается при врожден-ных аномалиях лимфатической системы и встречается достаточно редко. Вторичная лимфедема формируется при поражении лимфатической системы области голо-вы и шеи после лечения опухолей данной локализации и при метастатическом поражении [1].Распространенность вторичной лимфедемы области головы и шеи значительно ниже по сравнению с рас-пространенностью вторичной лимфедемы конечностей [2]. Частота развития той или иной степени отека варьи-рует от 12,1 [3] до 90 % [4]. По данным J. Deng и соавт., в 2012 г. в США более 500 тыс. пациентов с опухолями головы и шеи находятся в группе риска развития лим-федемы [5]. Авторы отмечают, что лимфедема данной локализации чаще встречается при опухолевом пораже-нии гортани [5]. По другим данным, вторичная лимфе-дема чаще развивается у пациентов с опухолями рото-глотки (p = 0,044) [6]. Основные методы лечения опухолей данной локализации -хирургическое вмеша-тельство и лучевая терапия, и использование каждого их них может привести к появлению отека.A. Sember и соавт. опубликовали результаты ис-следования, проведенного в 2008-2015 гг. в Roy and Patricia Disney Family Cancer Center (США, Калифорния) с участием 190 пациентов с опухолями головы и шеи.

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Section: диагностикаunclassified

Lymphedema after combination treatment of head and neck tumors

et al. 2018

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“…The overall prevalence of lymphedema among head and neck cancer patients ranges from 12% and 75% (9,14,22). This discrepancy may be explained by a lack of a standard diagnosis and universal assessment criteria, as well as differences among the therapeutic procedures used to treat this type of cancer (7,9,22).…”

Section: General Aspects Of Head and Neck Lymphedemamentioning

confidence: 99%

“…Assessment is essential for the effective treatment of lymphedema, however, most studies addressing the topic report that the instruments used to measure head and neck cancer-related lymphedema are insuf icient because the procedures used to treat this type of cancer are mutilating and involve the resection of lymph nodes and other structures, reducing tissue volume in the compromised area, hindering the effective use of circumferential techniques or veri ication of the distance between two landmarks (7,9,18,22,24,25).…”

Section: Instruments and Techniques Used To Assess Head And Neck Lympmentioning

confidence: 99%

“…Even though many of these treatments are effective in eradicating the tumor and/ or generate better results in regard to survival, local control and preservation of function, these interventions usually involve co-morbidities (5). The followup of patients after cancer treatment is important because there may be some after-effects, such as lymphedema (7,8,9).…”

Section: Introductionmentioning

confidence: 99%

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Head and neck lymphedema: what is the physical therapy approach? A literature review

Justina

Dias

2016

Fisioter. mov.

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Introduction: Head and neck lymphedema is considered a chronic and complex complication with potential to cause physical, functional, emotional and social impairment. Objective: To identify the approaches to physical therapy used to treat head and neck cancer-related lymphedema. Method: A bibliographic search was conducted in February and March 2012 in books and electronic databases, LILACS, MEDLINE, SCIELO, Cochrane, PEDro, and BDTD using the following keywords: lymphedema, treatment, head and neck cancer, and physical therapy connected by the Boolean operator AND without a speci ic time frame. Results and discussion: Early diagnosis and assessment is key to properly managing and effectively treating lymphedema. Diagnosis is reached through clinical history and physical assessment by measuring the distance between two anatomical landmarks, circumference measures, and lymphedema rating scales. Complex decongestive therapy, which includes manual lymph drainage, compressive bandaging, kinesiotherapy and skin care, is the technique most frequently used and currently considered to be the gold standard. Conclusions: No consensus is reported in the literature in regard to a standard procedure to assess and treat head and neck cancer-related lymphedema. Assessments and treatments described in the literature are mainly restricted to the limbs; therefore, further studies are needed to support effective clinical actions in the physical therapy approach to this condition.Keywords: Lymphedema. Head and neck neoplasms. Physical therapy modalities. Therapeutics.

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Monitoring Adverse Effects of Radiation Therapy in Patients With Head and Neck Cancer

Gharzai,

Mierzwa,

Peipert

et al. 2023

JAMA Otolaryngol Head Neck Surg

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ImportancePatients undergoing radiation therapy (RT) for head and neck squamous cell carcinoma (HNSCC) experience a range of debilitating adverse effects (AEs). Patient-reported outcome (PRO) measures to quantify these AEs are a necessary and important component of health care; however, currently available PRO options often measure only disease-related symptoms or AEs of non-RT treatments.ObjectiveTo develop a brief PRO measure of the most common AEs associated with RT for HNSCC.Design, Setting, and ParticipantsThis was a qualitative study that followed the US Food and Drug Administration guidelines to develop a brief measure of patient-reported RT-related AEs (the Functional Assessment of Cancer Therapy–Head and Neck Radiotherapy [FACT-HN-RAD] measure). The study included (1) a literature review of clinical trials; (2) secondary analysis of retrospective concept elicitation interviews (CEIs); (3) electronic surveys of practicing radiation oncologists; (4) mapping of existing items to inform the development of the draft version of the measure; and (5) validation of content and face validity via patient cognitive interviews. Analysis was performed of CEI data and interviews with practicing radiation oncologists. Data analysis was conducted from July 1, 2022, to April 21, 2023.ExposuresSurveys and qualitative interviews.Main Outcomes and MeasuresThe most common patient-reported RT-related AEs among patients with HNSCC.ResultsOf 19 CEI participants, 14 (mean [range] age, 67 [49-86] years; 12 [86%] men and 2 [14%] women) described RT-related AEs and were included in the secondary analysis. Eleven (79%) patients reported difficulty swallowing; 8 (57%), oral pain; 7 (50%), dry mouth; 7 (50%), weight loss; 6 (43%), skin burning; 5 (36%), loss of taste; 5 (36%), voice changes (36%); and 5 (36%), fatigue. Nine radiation oncologists (mean [range] time in practice, 8 [1-42] years; 5 [56%] men and 4 [44%] women) reported the most common AEs: 9 (100%) reported dysgeusia; 7 (78%), xerostomia; 7 (78%), mucositis or oral pain; 8 (89%), dysphagia or odynophagia; 6 (67%), dermatitis; and 3 (33%), fatigue. Together these data informed the development of an 8-item AE-focused measure of pain, dysphagia, xerostomia, dysgeusia, voice changes, dermatitis, fatigue, and weight loss. Cognitive interviews with 10 patients (mean [range] age, 61 [29-84] years; 8 [80%] men and 2 [20%] women) demonstrated strong face validity; all (100%) reported that the measure reflected their experience with RT and stated that the length of the questionnaire was “just right.”Conclusions and RelevanceThe 8-item FACT-HN-RAD measure captures the most common patient- and physician-reported AEs related to RT for HNSCC. This measure offers a means to serially monitor patient-reported treatment-related AEs and recovery over time in both clinical and research settings. Future work will evaluate the psychometric validity of the measure.

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Prevalence of Secondary Lymphedema in Patients With Head and Neck Cancer

Cited by 172 publications

References 14 publications

Lymphedema after combination treatment of head and neck tumors

Lymphedema after combination treatment of head and neck tumors

Head and neck lymphedema: what is the physical therapy approach? A literature review

Monitoring Adverse Effects of Radiation Therapy in Patients With Head and Neck Cancer

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