Prevalence of schizophrenia and its association with socio-demographic correlates in an agricultural region of China

Rao, Wenwang; Zhang, Yun Shu; Ng, Chee H.; Cui, Li Jun; Li, Jian Feng; Li, Lin; Ungvári, Gábor S.; Li, Ke Qing; Xiang, Yu Tao

doi:10.1016/j.ajp.2021.102743

Cited by 9 publications

(4 citation statements)

References 49 publications

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“…This limitation may be attributed to local contextual factors and publication bias, where studies with negative results are less likely to be prioritized for publication. It is noteworthy that China has been reported to have a higher prevalence of schizophrenia (2.64% globally [36] compared to 65% to 8.3% in China [7,37] ) and severe air pollution due to rapid industrialization. Secondly, although the methodological quality assessment scale employed in this study has been previously used in systematic reviews, its validity has not been scientifically established.…”

Section: Highmentioning

confidence: 99%

The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis

Xu,

Lan,

et al. 2023

Medicine

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Background: Ambient air pollution has been identified as a primary risk factor for mental disorders. In recent years, the relationship between exposure to ambient nitrogen dioxide (NO2) and the risk of hospital admissions (HAs) for schizophrenia has garnered increasing scientific interest, but evidence from epidemiological studies has been inconsistent. Therefore, a systematic review and meta-analysis were conducted to comprehensively identify potential correlations. Methods: A literature search in 3 international databases was conducted before December 31, 2022. Relative risk (RR) and corresponding 95% confidence intervals (CI) were calculated to evaluate the strength of the associations. Summary effect sizes were calculated using a random-effects model due to the expected heterogeneity (I 2 over 50%). Results: A total of ten eligible studies were included in the meta-analysis, including 1,412,860 participants. The pooled analysis found that an increased risk of HAs for schizophrenia was associated with exposure to each increase of 10 μg/m3 in NO2 (RR = 1.029, 95% CI = 1.016–1.041, P < .001). However, the heterogeneity was high for the summary estimates, reducing the credibility of the evidence. In 2-pollutant models, results for NO2 increased by 0.3%, 0.2% and 2.3%, respectively, after adjusting for PM2.5, PM10 and SO2. Conclusions: This study provides evidence that NO2 exposure significantly increases the risk of hospital admission for schizophrenia. Future studies are required to clarify the potential biological mechanism between schizophrenia and NO2 exposure to provide a more definitive result.

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Section: Highmentioning

confidence: 99%

The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis

Xu,

Lan,

et al. 2023

Medicine

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“…Schizophrenia is considered a severe neuropsychiatric disorder characterized by heterogeneous symptomatology, cognitive impairment and significant behavioral dysfunction [1,2], and affects approximately 23.6 million people worldwide [3][4][5]. Compared to the general population, schizophrenia poses a high impact on people's quality of life reducing life expectancy by 10 to 25 years and with high rates of premature mortality [6,7].…”

Section: Introductionmentioning

confidence: 99%

Latent Profiles of Premorbid Adjustment in Schizophrenia and Their Correlation with Measures of Recovery

Caqueo-Urízar

Ponce-Correa

Semir-González

et al. 2022

JCM

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Premorbid adjustment (PA) has classically been defined as psychosocial functioning in the areas of education, occupation, social and interpersonal relationships prior to evidence of characteristic positive symptomatology. It is a concept which possesses ample evidence regarding its predictive nature for the course of Schizophrenia. The study aimed to analyze the latent profiles of premorbid adjustment and their relationship with symptomatology, functionality, subjective recovery, stigma resistance and years of untreated psychosis. Latent class analysis (LCA) was used to elaborate a solution of three premorbid adjustment profiles in a sample of 217 patients diagnosed with Schizophrenia from Public Mental Health Centers in the city of Arica, Chile. The results show that premorbid adjustment was significantly correlated with recovery indicators and that latent profiles of better premorbid adjustment predict better outcomes in subjective recovery and stigma resistance. The results show that premorbid adjustment not only has implications for the severity of the disorder, but that psychosocial functioning prior to psychosis affects the patient’s subjectivity, the representation of the disorder and the recovery process.

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“…Schizophrenia (SCZ) is a debilitating mental disorder. [1][2][3] It's known as one of the leading causes of disability in men and women. 4 The global prevalence of SCZ is between 0.3-0.7% and usually happens in late adolescence and early adulthood.…”

Section: Introductionmentioning

confidence: 99%

“…4 The global prevalence of SCZ is between 0.3-0.7% and usually happens in late adolescence and early adulthood. [1][2][3] Cognitive impairments, thinking problems, behavior disorders, and hallucination are some of the clinical manifestations of SCZ. 5 A definite etiology for SCZ is uncertain still, but genetic, dysfunction of the immune system, and environmental factors (such as infectious agents, season, birthplace, exposure to viruses, low birth weight, high paternal age, tobacco) can affect SCZ progression.…”

Section: Introductionmentioning

confidence: 99%

A Study of Autoantibodies Against some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia

Soltani¹,

Beshkar²,

Mokhtarian³

et al. 2022

IJAAI

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Schizophrenia (SCZ) is a debilitating mental disorder with various causes involving complex interactions between genetic factors and environmental agents. The immune system plays a vital role in the pathology and function of the nervous system. Interleukin 35 (IL-35) is a regulatory and anti-inflammatory cytokine that can prevent autoimmune and inflammatory diseases. This study aimed to investigate the role of autoantibodies against some central nervous system (CNS) antigens and IL-35 serum levels in patients with Schizophrenia. This case-control study involved 80 participants. The serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the autoantibodies in the CNS by indirect immunofluorescence assay (IFA). The serum levels of IL-35 were decreased in patient groups compared to healthy subjects. Autoantibodies against N-methyl-D-aspartate receptor (NMDAR) and myelin-associated glycoprotein (MAG) were positive in 15% (6/40) and 7.5% (3/40), respectively; however, no antibodies against myelin, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG), We found that decreased serum IL-35 levels and the existence autoantibodies against NMDAR antigen may contribute to the pathogenesis of SCZ.

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Prevalence of schizophrenia and its association with socio-demographic correlates in an agricultural region of China

Cited by 9 publications

References 49 publications

The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis

The association between short-term exposure to nitrogen dioxide and hospital admission for schizophrenia: A systematic review and meta-analysis

Latent Profiles of Premorbid Adjustment in Schizophrenia and Their Correlation with Measures of Recovery

A Study of Autoantibodies Against some Central Nervous System Antigens and the IL-35 Serum Level in Schizophrenia

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