Prevalence of SARS-CoV-2 Infection in a Sample of Health Workers in Two Health Departments of the Valencian Community in Spain

Ramírez, Kenan Rodríguez de Limia; Ruiz‐Robledillo, Nicolás; Torrijos, J.L. Duro; García-Román, Vicente; Albaladejo-Blázquez, Natalia; Ferrer‐Cascales, Rosario

doi:10.3390/ijerph19010066

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…The first objective was to evaluate the incidence of SARS-CoV-2 infection in HCW of HGMEL, and to compare results from the qPCR and IgG tests. The incidence rate of SARS-CoV-2 infection was considerably higher in our cohort (58%) than in other healthcare populations as published by other authors (5-29%) [2][3][4][5][6][7][8][9]. Most reports used qPCR tests to detect positive cases.…”

Section: Introductionsupporting

confidence: 43%

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Lecona,

Arroyo-Valerio,

Bueno-Hernández

et al. 2024

PLoS ONE

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Throughout the early stages of the COVID-19 pandemic in Mexico (August—December 2020), we closely followed a cohort of n = 100 healthcare workers. These workers were initially seronegative for Immunoglobulin G (IgG) antibodies against SARS-CoV-2, the virus that causes COVID-19, and maintained close contact with patients afflicted by the disease. We explored the database of demographic, physiological and laboratory parameters of the cohort recorded at baseline to identify potential risk factors for infection with SARS-CoV-2 at a follow-up evaluation six months later. Given that susceptibility to infection may be a systemic rather than a local property, we hypothesized that a multivariate statistical analysis, such as MANOVA, may be an appropriate statistical approach. Our results indicate that susceptibility to infection with SARS-CoV-2 is modulated by sex. For men, different physiological states appear to exist that predispose to or protect against infection, whereas for women, we did not find evidence for divergent physiological states. Intriguingly, male participants who remained uninfected throughout the six-month observation period, had values for mean arterial pressure and waist-to-hip ratio that exceeded the normative reference range. We hypothesize that certain risk factors that worsen the outcome of COVID-19 disease, such as being overweight or having high blood pressure, may instead offer some protection against infection with SARS-CoV-2.

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Section: Introductionsupporting

confidence: 43%

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Lecona,

Arroyo-Valerio,

Bueno-Hernández

et al. 2024

PLoS ONE

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“…В соответствии с классификацией ВОЗ сотрудники были подразделены на три группы: 1-я группа -молодой возраст (18-44 года), 19 человек; 2-я группа -средний (44-60 лет), 10 человек и 3-я группа -пожилой (60-75 лет), 11 человек. Средний возраст в группах составил 33 (28)(29)(30)(31)(32)(33)(34)(35)(36)(37) года, 48 (46-54) лет и 61 (61-68) год соответственно.…”

Section: таблица 1 частота выявления Igm и Igg к Sars-cov-2 в зависим...unclassified

“…(2020), общая доля медработников с положительным результатом РНК SARS-CoV-2 среди всех пациентов с COVID-19 составила 10,1% (95% ДИ: 5,3-14,9) [34]. В отдельно взятых медицинских учреждениях она варьировала от 2,7% [20] и 5,62% (Иран) [33] до 12,1% (Испания) [31].…”

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Formation of anti-infectious and post-vaccination anti-SARS-CoV-2 humoral immunity in medical workers of the perinatal center

Chistyakova

Malgina

Ремизова

et al. 2022

Russian Journal of Infection and Immunity

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In the context of the global spread of the new coronavirus infection, studies aimed at investigating formation of anti-infectious and post-vaccination immunity are of special importance, which is necessary to prevent and reduce morbidity and mortality due to SARS-CoV-2 infection.Purpose: to assess anti-infectious immunity against SARS-COV-2 in various forms of the disease and development of post-vaccination humoral reactions in medical workers of the perinatal center. Materials and methods. A study of blood serum was carried out to assess SARS-CoV-2-specific IgM and IgG antibodies in 119 medical workers recovered after COVID-19, divided into groups based on the disease severity (mild, moderate and asymptomatic), as well as in 62 vaccinated employees, divided into groups according to age. Semi-quantitative measurement of virus-specific antibodies was carried out by ELISA with test systems "SARS-COV-2-IgG-ELISA-BEST" and "SARS-COV-2-IgM-ELISA-BEST".Statistical processing of the research results was carried out using Microsoft Excel 2010 and Statistica 6. Quantitative characteristics were presented as median (ME), lower and upper quartiles (LQ1-UQ3); qualitative parameters – as absolute value and relative number (%). Difference between groups was analyzed by using the χ2 test (qualitative) and the Mann-Whitney U-test (quantitative).Results. The results of the study showed that the majority of employees with a moderate-severe form of SARS-COV-2 had a high level of IgG (PR - a positivity rate of more than 9.0 arbitrary units) 9 months after the disease compared to those who suffered from mild or asymptomatic (83.3% versus 25.8% and 13.3%, p 0.017) infection. The duration of IgG circulation after former illness had no relation to its severity and patient age. The effectiveness of the primary vaccination "Sputnik V" and revaccination with "Sputnik Light" and "KoviVak" was 100% after inoculating the vaccine second component. The lowest level of antibodies after the first vaccination is recorded in persons over 60 years old (1.48 (1.12-3.25 versus PR = 8.48 (5.78-10.11) and 9.27 (5.84-10, 31) arbitrary units, p 0.017)), in comparison with young and middle-age subjects. The speed SARS-COV-2 elimination of IgG at 6, 9 or more months after vaccination depends on relevant initial peak antibody concentration. Subjects who were initially vaccinated with the KoviVac vaccine, IgG was not detected 2 months after vaccination. The protective effect of "Sputnik V", "Sputnik Light", "KoviVac" after re-infection with SARS-COV-2 averages 71.2%. Conclusion. Thus, the results obtained on assessing anti-infectious and post-vaccination immunity against SARS-CoV-2 emphasize the need for further studies on a larger patient cohort, especially in those with asymptomatic infection as well as the elderly subjects.

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“…And there is little data available regarding the prevalence of infection in HWs and close to none featuring their clinical, symptomatology, and OD associated with the infection. HWs are a high-risk group for contracting SARS-CoV-2 infection from patients, visitants, or other colleagues, due to their close contact [32][33][34]. In China, more than 2000 cases among HWs were infected by February 2020 [35].…”

Section: Introductionmentioning

confidence: 99%

Long-Lasting Olfactory Dysfunction in Hospital Workers Due to COVID-19: Prevalence, Clinical Characteristics, and Most Affected Odorants

Delgado-Losada

Bouhaben

Ruiz-Huerta

et al. 2022

IJERPH

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Hospital workers have increased exposure risk of healthcare-associated infections due to the frontline nature of their work. Olfactory dysfunction is highly prevalent. The objectives for this investigation are to study the prevalence of long-lasting olfactory dysfunction associated with COVID-19 infection in hospital workers during the first pandemic wave, to identify clinical characteristics and associated symptomatology, and to analyze how many patients with COVID-19 infection had developed olfactory dysfunction during infection and maintained a reduced olfactory function for approximately 10 weeks after diagnosis. Between June and July of 2020, a cross-sectional study was carried out at the Hospital Central de la Cruz Roja San José and Santa Adela in Madrid, Spain. One hundred sixty-four participants were included, of which 110 were patient-facing healthcare staff and 54 were non-patient-facing healthcare staff. Participants were split into three groups, according to COVID-19 diagnosis and presence of COVID-19 related olfactory symptomatology. Participants were asked to complete a structured online questionnaire along with Sniffin’ Stick Olfactory Test measurements. In this study, 88 participants were confirmed for COVID-19 infection, 59 of those participants also reported olfactory symptomatology. The prevalence of COVID-19 infection was 11.35%, and the prevalence for olfactory dysfunction was 67.05%. Olfactory dysfunction associated with COVID-19 infection leads to long-lasting olfactory loss. Objective assessment with Sniffin’ Stick Olfactory Test points to odor identification as the most affected process. Lemon, liquorice, solvent, and rose are the odors that are worst recognized. Mint, banana, solvent, garlic, coffee, and pineapple, although they are identified, are perceived with less intensity. The findings of this study confirmed a high prevalence of SARS-CoV-2 infection among the hospital workers.

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Prevalence of SARS-CoV-2 Infection in a Sample of Health Workers in Two Health Departments of the Valencian Community in Spain

Cited by 5 publications

References 36 publications

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Risk factors contributing to infection with SARS-CoV-2 are modulated by sex

Formation of anti-infectious and post-vaccination anti-SARS-CoV-2 humoral immunity in medical workers of the perinatal center

Long-Lasting Olfactory Dysfunction in Hospital Workers Due to COVID-19: Prevalence, Clinical Characteristics, and Most Affected Odorants

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