Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020

Halatoko, Wemboo Afiwa; Konu, Yao Rodion; Gbeasor-Komlanvi, Fifonsi Adjidossi; Sadio, Arnold Junior; Tchankoni, Martin Kouame; Komlanvi, Koffi Segbeaya; Salou, Mounérou; Dorkenoo, Améyo Monique; Maman, issaka; Agbobli, Amétépé; Wateba, Majesté Ihou; Adjoh, K.S.; Akue, E. Goeh; Kao, Yem-Bla; Kpeto, Innocent K; Pana, Paul; Kinde-Sossou, Rebecca; Tamekloe, Agbeko; Nayo-Apétsianyi, Josée; Assane, Simon-Pierre Hamadi; Prince-David, Mireille; Awoussi, Sossinou Marcel; Djibril, Mohaman Awalou; Mijiyawa, M; Dagnra, Anoumou Claver; Ekouévi, Didier K.

doi:10.1101/2020.08.07.20163840

Cited by 11 publications

(16 citation statements)

References 13 publications

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“…This study was part of a survey aimed at describing the prevalence of SARS-CoV-2 in high-risk populations in Lomé (capital city of Togo) [21]. It was a cross-sectional study conducted from April 23 rd to May 8 th , 2020.…”

Section: Study Design and Samplingmentioning

confidence: 99%

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Assessment of self-medication practices in the context of Covid-19 outbreak in Togo

Sadio

Gbeasor-Komlanvi

Konu

et al. 2020

Preprint

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Background: To date, there is no effective treatment for Covid-19 which is a pandemic due to a new coronavirus called SARS-CoV-2. In Togo, where four in five people practice self-medication, the absence of a cure for Covid-19 and its constant progression requires an assessment of self-medication patterns in the context of the pandemic. This study aimed at estimating the prevalence of self-medication to prevent Covid-19 and its associated factors in Lomé, Togo. Methods: A cross-sectional study was conducted in Lomé, capital city of Togo, from April 23rd to May 8th, 2020 in a sample of participants from five sectors: healthcare, air transport, police, road transport and informal. Participants were invited to give information about their self-medication practices to prevent Covid-19 within the two weeks preceding the survey. Results: A total of 955 participants (71.6% of men) with a median age of 36 (IQR 32–43) were included. Around 22.1% were in the air transport sector, 20.5% in police, and 38.7% in the health sector. The overall prevalence of self-medication to prevent Covid-19 was 34.2% (95CI%: 31.2-37.3%). Most commonly used products were vitamin C (27.6%) and traditional medicine (10.2%). Only 2.0% of participants reported using Chloroquine/Hydroxychloroquine. Female sex (aOR=1.90; p<0.001), working in the health sector (aOR=1.89; p= 0.001), secondary education level (aOR= 2.28; p= 0.043) and university education level (aOR= 5.11; p<0.001) were associated with self-medication. Conclusion: One third of high-risk populations in Lomé have practiced self-medication. Intensifying awareness campaigns is crucial to fight misinformation about alleged Covid-19 prevention products on social media.

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Section: Study Design and Samplingmentioning

confidence: 99%

“…It was a cross-sectional study conducted from April 23 rd to May 8 th , 2020. A total of 955 participants were included, and the prevalence of SARS-CoV-2 was 0.7% according to Polymerase Chain Reaction test [21].…”

Section: Study Design and Samplingmentioning

confidence: 99%

Assessment of self-medication practices in the context of Covid-19 outbreak in Togo

Sadio

Gbeasor-Komlanvi

Konu

et al. 2020

Preprint

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“…Using commercial point of care tests, community serosurveillance throughout 2020 has identified gradually increasing seroprevalence rates in West African countries, including 0.9% in Togo in April, 25.4% in Nigeria in June, and 25.1% in Côte d'Ivoire in October [7][8][9]. Similarly, surveys in other parts of the continent using laboratory-based single antigen ELISA have estimated seroprevalence rates of 4.3% in Kenyan blood donors in June 2020, 2.1% in households in Zambia in July, and up to 60% in blood donors in parts of South Africa in January 2021 [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study

Sagara

Woodford

Kone

et al. 2021

Preprint

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Background The extent of SARS-CoV-2 exposure and transmission in Mali and the surrounding region is not well understood, although infection has been confirmed in nearly 14,000 symptomatic individuals and their contacts since the first case in March 2020. We aimed to estimate the cumulative incidence of SARS-CoV-2 in three Malian communities, and understand factors associated with infection. Methods Between 27 July 2020 and 29 January 2021, we collected blood samples along with demographic, social, medical and self-reported symptoms information from residents aged 6 months and older in three study communities at two study visits. SARS-CoV-2 antibodies were measured using a highly specific two-antigen ELISA optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each site and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis. Findings Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 50.3% (1343/2672) of participants were male, and 31.3% (837/2672) were aged <10 years, 27.6% (737/2672) were aged 10-17 years, and 41.1% (1098/2572) were aged >/=18 years. The cumulative SARS-CoV-2 exposure rate was 58.5% (95% CI: 47.5 to 69.4). This varied between sites and was 73.4% (95% CI: 59.2 to 87.5) in the urban community of Sotuba, 53.2% (95% CI: 42.8 to 63.6) in the rural town of Bancoumana, and 37.1% (95% CI: 29.6 to 44.5) in the rural village of Doneguebougou. This equates to an infection rate of approximately 1% of the population every three days in the study communities between visits. Increased age and study site were associated with serostatus at both study visits. There was minimal difference in reported symptoms based on serostatus. Interpretation The true extent of SARS-CoV-2 exposure in Mali is greater than previously reported and now approaches hypothetical herd immunity in urban areas. The epidemiology of the pandemic in the region may be primarily subclinical and within background illness rates. In this setting, ongoing surveillance and augmentation of diagnostics to characterize locally circulating variants will be critical to implement effective mitigation strategies like vaccines. Funding This project was funded by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering, and National Cancer Institute.

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“…, 2020 ), South Africa ( Goldblatt et al. , 2021 ), Togo ( Halatoko et al. , 2020 ), Zambia ( Fwoloshi et al.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence and risk factors of COVID-19 in healthcare workers from 11 African countries: a scoping review and appraisal of existing evidence

Müller

Wood

Hanefeld

et al. 2021

Health Policy and Planning

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A better understanding of serological data and risk factors for coronavirus disease 2019 (COVID-19) infection in healthcare workers (HCWs) is especially important in African countries where human resources and health services are more constrained. We reviewed and appraised the evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence and its risk factors in HCWs in Africa to inform response and preparedness strategies during the SARS-CoV-2 pandemic. We followed the Preferred Reporting Items for systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines in this scoping review. Databases including PubMed, Embase and preprint servers were searched accordingly from the start of the COVID-19 pandemic to 19 April 2021. Our search yielded 12 peer-reviewed and four pre-print articles comprising data on 9223 HCWs from 11 countries in Africa. Seroprevalence varied widely and ranged from 0% to 45.1%. Seropositivity was associated with older age, lower education, working as a nurse/non-clinical HCW or in gynaecology, emergency, outpatient or surgery departments. Asymptomatic rates were high and half of the studies recommended routine testing of HCWs. This scoping review found a varying but often high SARS-CoV-2 seroprevalence in HCWs in 11 African countries and identified certain risk factors. COVID-19 public health strategies for policy and planning should consider these risk factors and the potential for high seroprevalence among HCWs when prioritizing infection prevention and control measures and vaccine deployment.

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Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020

Cited by 11 publications

References 13 publications

Assessment of self-medication practices in the context of Covid-19 outbreak in Togo

Assessment of self-medication practices in the context of Covid-19 outbreak in Togo

Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study

Seroprevalence and risk factors of COVID-19 in healthcare workers from 11 African countries: a scoping review and appraisal of existing evidence

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