Prevalence of sarcopenia in multi ethnics adults and the association with cognitive impairment: findings from West-China Health and Aging Trend Study

Abstract

BackgroundSarcopenia is a condition that is characterized by loss of muscle mass, muscle strength and muscle functional impairment with ageing. It is associated with poor health outcomes, premature death and a significant burden on the global health economy. The prevalence of sarcopenia in China is unknown since most of the studies are lack of uniform standard. The study was undertaken to study the prevalence of sarcopenia and the association with cognitive impairment among multi-ethnic adults aged 50 years old or older in western China. MethodsWe measured gait speed, handgrip strength and muscle mass by using bioelectrical impedance analysis (BIA) for all eligible participants and 4500 participants were eligible for the analysis. We defined sarcopenia using the diagnostic algorithm recommended by the Asian Working Group for Sarcopenia (AWGS) . We assessed the participants' cognitive functions using the 10-item Short Portable Mental Status Questionnaire (SPMSQ) . Relationships between sarcopenia and cognitive impairment were analyzed using univariate and multivariate analyses. ResultsOf 4500 participants (mean age 62.4 ± 8.3 years), 869 (19.31%) adults were sarcopenia. 446 (9.9%) participants were identified as having mild cognitive impairment, 144 (3.2%) adults were identified as having moderate/severe cognitive impairment. After adjusting for age, gender, ethnics and other potential cofounders, cognitive impairment was found to be independently associated with sarcopenia with a dosage effect (mild cognitive impairment: odds ratio [OR] : 1.52, 95% CI 1.18-1.95; moderate/severe cognitive impairment: OR: 3.26, 95% CI 2.23-4.76). After gender stratification, the association between mild cognitive impairment with sarcopenia in male is not significant, while is still significant in female. While the association between moderate/severe cognitive impairment is independently associated with sarcopenia in both male and female. ConclusionsThe prevalence rates of sarcopenia, mild cognitive impairment, moderate/severe cognitive

Correlation between Sleep Quality and Frailty Status among Middle-Aged and Older Taiwanese People: A Community-Based, Cross-Sectional Study

“…In our study, participants with lower ASMI, lower gait speed, lower hand grip strength, female, lower education level, and underlying diseases of HTN and dyslipidemia had higher proportion in the group with CPSQI scores > 5. According to previous studies, people with sarcopenia diagnosed by low ASMI, slow gait speed, and low hand grip strength had poor self-reported sleep quality [ 25 ]. Sleep complaints were relatively more prevalent in women compared to men.…”

Predicting non-elective hospital readmission or death using a composite assessment of cognitive and physical frailty in elderly inpatients with cardiovascular disease

“…In fact, many of the adverse outcomes of physical frailty may be mediated by sarcopenia, which may be considered the biological substrate for the development of frailty [28]. Cognitive impairment reinforces the neuronal changes in the central nervous system leading to changes in the levels and activity of neurotransmitters, which lead to a reduction in motor units and in the ability to maintain muscle activation, which might be related to sarcopenia [29].…”

Predicting Non-elective hospital readmission or Death using a Composite Assessment of Cognitive and Physical Frailty in Elderly inpatients with Cardiovascular Disease

“…In fact, many of the adverse outcomes of physical frailty may be mediated by sarcopenia, which may be considered the biological substrate for the development of frailty [30]. Cognitive impairment reinforces the neuronal changes in the central nervous system leading to changes in the levels and activity of neurotransmitters, which lead to a reduction in motor units and in the ability to maintain muscle activation, which might be related to sarcopenia [31].…”