Prevalence of sarcopenia and relevance of body composition, physiological function, fatigue, and health-related quality of life in patients before allogeneic hematopoietic stem cell transplantation

Abstract

Sarcopenia is common in patients before allo-HSCT and related to low muscle strength, fatigue, and health-related QOL. Male patients may be more susceptible to sarcopenia than female patients before allo-HSCT. Further study of rehabilitation with gender insight is warranted for patients receiving allo-HSCT.

Impact of pretransplant body mass index on the clinical outcome after allogeneic hematopoietic SCT

“…33,34 Exercise is important for maintaining skeletal muscle mass, and sufficient nutritional support is essential for preventing catabolism, since previous reports have demonstrated a high prevalence of sarcopenia before allogeneic HSCT. [33][34][35] This study has some limitations. Because of the nature of the registry database, we were not able to assess the policies regarding adjustment of the conditioning regimen dose for patients with obesity, which will likely vary among the transplant centers.…”

Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation

“…BIA has been shown to provide highly discrepant results when compared with gold standard methodologies [34]; however, body composition analyzed by DEXA has also been shown to be highly correlated with that analyzed by BIA [35]. Furthermore, Morishita et al [36] and Janssen et al [37] have used BIA to evaluate body composition. The body composition measurement conducted in this study using the BIA method is safe, convenient, and noninvasive [37,38].…”

Physical Exercise for Patients Undergoing Allogeneic Haematopoietic Stem Cell Transplantation

“…In a previous study, we observed that patients who underwent allo-HSCT had significantly lower body mass index and physical function than the normal population, even before undergoing the transplantation [25]. We also showed that roughly half of the study population had sarcopaenia before undergoing allo-HSCT [26]. On the basis of these findings, we concluded that physical exercise should be initiated as soon as possible during the hospitalization of allo-HSCT patients.…”