Prevalence of sarcopenia and clinical implications in patients with newly diagnosed rheumatoid arthritis

Ekici, Remzi; Erden, Abdülsamet; Güven, Serdar Can; Armağan, Berkan; Özdemir, Bahar; Karakaş, Özlem; Gök, Kevser; Omma, Ahmet; Küçükşahin, Orhan; Erten, Şükran

doi:10.1016/j.nut.2021.111353

Cited by 10 publications

(20 citation statements)

References 29 publications

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“…The material used in this experiment is 316L stainless steel spherical powder prepared by the plasma atomization process of Sandvik, Sweden. The bulk density is 3.55 g/cm 3 and the tap density is 4.8 g/cm 3 , which meets the requirements of use. Its specific chemical composition is shown in Table 1.…”

Section: Methodsmentioning

confidence: 60%

“…These bone diseases are difficult to recover through self-healing and usually require surgical repair or replacement. According to statistics, hundreds of millions of residents in my country are affected by skeletal diseases to varying degrees, and with the aging of the population and traffic accidents increase, people's demand for human bone replacement surgery is also increasing [3].…”

Section: Introductionmentioning

confidence: 99%

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Personalized Artificial Tibia Bone Structure Design and Processing Based on Laser Powder Bed Fusion

et al. 2022

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Bone defects caused by bone diseases and bone trauma need to be implanted or replaced by surgery. Therefore, it is of great significance to design and prepare a tibial implant with good biocompatibility and excellent comprehensive mechanical properties. In this paper, with 316L stainless steel powder as the main material, a personalized artificial tibia design and processing method based on laser powder bed fusion is proposed. Firstly, the personalized model of the damaged part of the patient is reconstructed. Then, the porous structure of human tibia is manufactured by selective laser melting technology. To research the factors affecting the quality of selective laser melting porous structure, a laser heat source model, heat transfer model and molten pool model of laser powder bed fusion process were constructed; then, by changing the laser process parameters (laser power, laser beam diameter, scanning speed, powder layer thickness, etc.) to conduct multiple sets of simulation experiments, it is obtained that when the “laser power is 180 W, the laser scanning speed is 1000 mm/s, the laser beam diameter is 80 μm, the powder layer thickness is 50 μm”, the porous stainless steel parts with better quality can be obtained. Finally, the porous structure was fabricated by selective laser processing, and its properties were tested and analyzed. The experimental results show that the cell side length of cube is 1.2 mm, the elastic modulus of octahedral porous structure with pillar diameter of 0.35 mm is about 17.88 GPa, which match well with tibial bone tissue.

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Section: Methodsmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Personalized Artificial Tibia Bone Structure Design and Processing Based on Laser Powder Bed Fusion

et al. 2022

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“…Dao et al found the prevalence of muscle mass loss was 18.1% in female patients with early RA ( n = 105, disease duration ≤ 36 months) ( 18 ). Recently, Ekici et al showed 31.5% of patients with newly diagnosed RA manifested loss of muscle mass ( n = 91, disease duration 1–35 months) ( 19 ). Our large-scale study of 1,008 patients with RA confirmed the higher prevalence of myopenia in the patients with early RA (disease duration ≤ 12 months) compared with the age- and gender-matched controls (41.3 vs. 15.8%).…”

Section: Discussionmentioning

confidence: 99%

Muscle mass loss is associated with physical dysfunction in patients with early rheumatoid arthritis

et al. 2022

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BackgroundMuscle mass loss is common in long-standing rheumatoid arthritis (RA). The aim was to explore the prevalence and effects of RA disease characteristics in patients with early RA.MethodsThis cross-sectional study was carried out based on a Chinese RA cohort and control subjects. The body composition (BC) was assessed using bioelectric impedance analysis. Myopenia was defined by an appendicular skeletal muscle mass index of ≤ 7.0 kg/m2 in men and ≤ 5.7 kg/m2 in women. Physical dysfunction was defined as a health assessment questionnaire disability index > 1. Propensity score matching was performed to balance age and gender differences among patients with early RA (disease duration ≤ 12 months) and established RA, and controls (with 1:3:3 matching).ResultsIn total, 2017 controls and 1,008 patients with RA were recruited for this study. Among the patients with RA, there were 190 (18.8%) patients with early RA, with a median disease duration of 7 (4, 11) months. The matched patients with early RA (n = 160) showed a higher prevalence of myopenia than the matched controls (41.3 vs. 15.8%, P < 0.0167), but no difference was found in the matched patients with established RA (41.3 vs. 50.4%, P > 0.0167). Compared with the patients with established RA, the patients with early RA exhibited higher disease activity scores [disease activity score in 28 joints with four variables including C-reactive protein (DAS28-CRP): median 4.76 vs. 3.93, P < 0.001] and a higher prevalence of physical dysfunction (26.3 vs. 19.4%, P = 0.035). In the patients with early RA, patients with myopenia showed a higher prevalence of physical dysfunction than those without myopenia (41.3 vs. 15.5%, P < 0.001), among which walking and common daily activities were the most involved subdimensions. Multivariate logistic regression analysis showed that DAS28-CRP was positively associated with myopenia [adjusted odds ratio (AOR) 1.558, 95% CI (1.138–2.132)], and myopenia [AOR 2.983, 95% CI (1.192–7.465)] was independently associated with physical dysfunction in the patients with early RA.ConclusionOur data indicate the importance of early detection of muscle involvement in the early stage of RA and imply the significance of early aggressive control of disease activity for the prevention of myopenia and physical dysfunction in patients with early RA. Our study provides a new perspective on RA management.

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“…Furthermore, specific RA characteristics, such as increasing joint deformity, patient-reported disability scores, elevated c-reactive protein (CRP) concentrations, rheumatoid factor seropositivity, and a lack of current treatment with disease-modifying antirheumatic drugs (DMARDs) were associated with abnormal body composition phenotypes. 31 Ecici 32 noted that 31.5% of the newly diagnosed, treatment-naive patients with RA exhibited sarcopenia, with a greater prevalence among men. Furthermore, 3 months of DMARD treatment appeared to reduce this prevalence, although grip strength was further reduced since diagnosis.…”

Section: Epidemiology: Primary Research On the Prevalence Of Rcmentioning

confidence: 99%

“…Furthermore, 3 months of DMARD treatment appeared to reduce this prevalence, although grip strength was further reduced since diagnosis. 32 …”

Section: Epidemiology: Primary Research On the Prevalence Of Rcmentioning

confidence: 99%

Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management

Efthymiou

Grammatikopoulou

Gkiouras

et al. 2022

MJR

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Cachexia is an early result of rheumatoid arthritis (RA) (rheumatoid cachexia, RC), characterised mainly by involuntary loss of fat-free mass. RC is apparent in 1–67% of patients with RA, depending on the diagnostic criteria applied and the method used for the assessment of body composition. RC is associated with increased inflammation and disability, lower health perception, and greater mortality risk. These changes in body composition are driven by the inflammation process, the low levels of physical activity, the underlying testosterone deficiency and hypogonadism, and the pharmacotherapy required for RA. Chronic inflammation enhances resting energy expenditure as a response to stress, inducing an energy deficit, further propelling protein turnover. The use of corticosteroids and tumour necrosis factor α (TNF-α) inhibitors tend to increase fat accumulation, whereas other disease-modifying antirheumatic drugs (DMARDs) appear to induce increments in fat-free mass. The present review presents all information regarding the prevalence of RC, diagnostic criteria, and comorbidities, as well as the effects of pharmacotherapy and medical nutrition therapy on body composition of patients with RA.

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Prevalence of sarcopenia and clinical implications in patients with newly diagnosed rheumatoid arthritis

Cited by 10 publications

References 29 publications

Personalized Artificial Tibia Bone Structure Design and Processing Based on Laser Powder Bed Fusion

Personalized Artificial Tibia Bone Structure Design and Processing Based on Laser Powder Bed Fusion

Muscle mass loss is associated with physical dysfunction in patients with early rheumatoid arthritis

Time to Deal with Rheumatoid Cachexia: Prevalence, Diagnostic Criteria, Treatment Effects and Evidence for Management

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