Prevalence of sarcopenia and associated factors in the healthy older adults of the Peruvian Andes

Tramontano, Alessandra; Veronese, Nicola; Sergi, Giuseppe; Manzato, Enzo; Rodríguez-Hurtado, Diana; Maggi, Stefania; Trevisan, Caterina; Zaiacomo, Francesca De; Giantin, Valter

doi:10.1016/j.archger.2016.09.002

Cited by 41 publications

(31 citation statements)

References 31 publications

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“…[29] Second, malnutrition that is common in older depressed people [30], is a significant risk factor for low muscle strength in the elderly population. [31][32][33] Third, depression is defined by DSM according to some criteria [34] (such as diminished interest, weight loss or weight gain, fatigue) which all might be responsible for dynapenia. Thus, the presence of common factors can further explain the association found in our research.…”

Section: Discussionmentioning

confidence: 99%

Depressive symptoms and muscle weakness: A two-way relation?

Bertoni

Maggi

Manzato

et al. 2018

Experimental Gerontology

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The potential association between depressive symptoms and dynapenia - i.e. muscle weakness - is limited to few, mainly cross-sectional, studies. We use SHARE (Survey on Health, Ageing and Retirement in Europe) panel data to investigate whether the onset of dynapenia at 4-year follow-up can be explained by pre-existing (either at baseline, or at 2-year follow-up) depressive symptoms, or vice versa. Depressive symptoms were identified as a score of 4 or more on the 12-item EURO-D scale. Individuals were classified as affected by dynapenia if they had handgrip strength of <20 kg for women and 30 kg for men. We estimate whether being affected by symptoms of depression at baseline or becoming symptomatic between baseline and a 2-year follow-up increases the odds-ratio (OR) for dynapenia at a 4-year follow-up among individuals with no muscle strength impairment at baseline. We also carry out the reverse analysis, and study whether dynapenia at baseline or incident dynapenia between baseline and first follow-up increase the probability that individuals develop depressive symptoms by the second follow-up. The analysis was carried out using multivariate logistic regression. After adjusting for a full set of potential confounders, being symptomatic for depression at baseline did not increase the risk of dynapenia at the 4-year follow-up. Instead, individuals developing depressive symptoms between baseline and the 2-year follow-up had a 34% increased risk of developing dynapenia at the 4-year follow-up (OR 1.34, 95% CI 1.02 1.66). No significant association was detected between dynapenia at baseline or the onset of dynapenia between baseline and the 2-year follow-up and the incidence of depressive symptoms at the 4-year follow-up. In conclusion, our results support the effect of the onset of depressive symptoms on the onset of dynapenia, even after considering the role of confounding factors.

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Section: Discussionmentioning

confidence: 99%

Depressive symptoms and muscle weakness: A two-way relation?

Bertoni

Maggi

Manzato

et al. 2018

Experimental Gerontology

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“…However, a recent study about prevalence of sarcopenia in community-dwelling older people living in a mountain region of Peruvian Andes, and evaluated by the International Work Group Sarcopenia (IWGS), could be taken as reference of indigenous Latin American population [24]. As previously mentioned, in our study we used the criteria proposed by the EWGSOP [4], adjusting the cut-off point for muscle mass in our study population as recommended in place of using another cut-off point for a population different from ours [4,23].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sarcopenia in community‐dwelling older people of Mexico City using the EGWSOP (European Working Group on Sarcopenia in Older People) diagnostic criteria

Espinel-Bermúdez

Ramírez-García

García-Peña

et al. 2017

JCSM Clinical Reports

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“…Likewise, Huo et al [9] reported a prevalence of 40% in a cohort of patients with a history of falls. Regarding Latin America, Tramontano et al [10] found a prevalence of sarcopenia of 18% in Peru, Gonzalez et al [11] found a prevalence of 53% in Colombia, and Lera et al [12] found a prevalence of 19% in Chile. In Ecuador, Maldonado and Ríos [13] determined a prevalence of sarcopenia of 66%; however, they did not study the relationship of this condition with osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

Bone Mass Loss and Sarcopenia in Ecuadorian Patients

Intriago

Maldonado

Guerrero

et al. 2020

Journal of Aging Research

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Introduction. An intimate relationship between osteoporosis and sarcopenia has been established. At present, there are few epidemiological studies about osteosarcopenia due to the recent use of this term, especially in Latin America. Objective. To study the association between osteoporosis and sarcopenia and determine the prevalence of osteosarcopenia in patients who attended a rheumatology center in Ecuador. Methods. A cross-sectional study was conducted in a population of patients who had a densitometric study. The diagnosis of sarcopenia was determined by the DXA standard gold test, screening, and conventional methods (bioimpedance, anthropometric measurements, SARC-F, muscle function, and gait test). Results. A total of 92 patients were studied. The median age was 66 ± 10, 90% females. Using the criteria of SMI, 65% had sarcopenia of which 9% had only sarcopenia and 56% had osteosarcopenia; 22% had only osteopenia/osteoporosis; and 13% none of these conditions. The prevalence of sarcopenia according to handgrip strength was 60%, gait speed 45%, and SARC-F score 40%. The prevalence of osteosarcopenia according to handgrip strength was 51%, gait speed 34%, and SARC-F score 32%. Osteoporosis was associated with a higher prevalence of sarcopenia using the criteria of SMI since 40% had sarcopenia in the normal DXA group, 64% in the osteopenia group, and 76% in the osteoporosis group (p=0.017). Of the women, 69% had sarcopenia compared to 33% of the men (p=0.034). The BMI was lower in the group with sarcopenia (25.1 ± 4.1 kg/m2) compared to the group without sarcopenia (29.4 ± 4.1 kg/m2, p<0.001). Patients with osteosarcopenia and sarcopenia had lower BMI, handgrip strength, ASM, SMI, and total-body skeletal muscle mass than those with osteopenia/osteoporosis or normal patients. Conclusion. 65% of the studied population had sarcopenia. It is clear that the prevalence of sarcopenia is higher in patients with greater loss of bone mass. Identifying pathways that affect both bone and muscle could facilitate the development of treatments that simultaneously improve osteoporosis and sarcopenia.

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Prevalence of sarcopenia and associated factors in the healthy older adults of the Peruvian Andes

Cited by 41 publications

References 31 publications

Depressive symptoms and muscle weakness: A two-way relation?

Depressive symptoms and muscle weakness: A two-way relation?

Prevalence of sarcopenia in community‐dwelling older people of Mexico City using the EGWSOP (European Working Group on Sarcopenia in Older People) diagnostic criteria

Bone Mass Loss and Sarcopenia in Ecuadorian Patients

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