Prevalence of rotavirus and human bocavirus in immunosuppressed individuals after renal transplantation in the Northern Region of Brazil

Abstract

Immunosuppressive therapy causes severe impairment of host defense and diarrhea is a frequent complication in renal transplant recipients. This study aimed to describe the occurrence of Rotavirus A (RVA) and Human Bocavirus (HBoV) in fecal samples of immunosuppressed patients submitted to renal transplantation during posttransplant follow‐up. A longitudinal study was carried out involving a 25‐patient cohort, selected for kidney transplantation. A total of 126 fecal samples were collected between May 2014 and May 2016. Molecular techniques were used to detect and characterize circulating RVA and HBoV genotypes and statistical analysis were applied to verify the association between epidemiological and clinical characteristics. The prevalence of RVA and HBoV was 24% (6/25) and 40% (10/25), respectively. Among RVA and HBoV positive cases, the majority was female; did not conduct water treatment nor had adequate sewage facilities. The most detected genotypes were RVA G3 (62.5%) and HBoV‐3 (95%). Phylogenetic analysis of HBoV strains indicated that studied samples were similar to those found in Asian and American countries. The present study point out the circulation of these viral agents among immunosuppressed individuals and these findings will enable the construction of new knowledge and care perspectives on the cause of diarrhea in this population.

Human Bocavirus in Brazil: Molecular Epidemiology, Viral Load and Co-Infections

“…Other studies performed in Brazil have accessed HBoV DNA in stool samples from patients with underlying medical conditions, such as HIV infected and immunosuppressed transplanted patients, showing detection rates varying from 13% to 21.4% [ 33 , 34 , 35 ]. Worldwide, several studies have detected HBoV in hospitalized children and outpatients with AGE at rates between 3.5% and 19.3%, in countries such as China, Spain, Chile, Pakistan and South Africa [ 14 , 36 , 37 , 38 , 39 , 40 ].…”

Common contributing factors to COVID-19 and inflammatory bowel disease

“…ID: “Immunosuppressive therapy causes severe impairment of host defense and diarrhea is a frequent complication in renal transplant recipients.” [ 124 ]…”

Bocavírus humano em amostras fecais de neonatos hospitalizados em Belém, Pará

“…Quando realizada a comparação da prevalência do HBoV1 com os resultados de estudos realizados em outra região do Brasil, percebe-se que este genótipo também foi o mais prevalente no estudo de Sousa e colaboradores (2012), na região Centro-Oeste no período de 1994 a 2004, com frequência de 91,6%. Entretanto, em outras pesquisas envolvendo este vírus no trato gastrointestinal, realizadas nas regiões Norte, Nordeste, Sudeste e Sul com amostras coletadas no período de 2014 a 2017 a identificação do HBoV1 também foi relatada, porém com menor frequência, quando comparado com outros genótipos identificados (Castro et al, 2019;Malta et al, 2020;Watanabe et al, 2018). Diante dos resultados apresentados nos estudos citados, percebe-se que houve uma mudança da prevalência dos genótipos do HBoV, no período de 2014 a 2016, onde o HBoV3 assumiu prevalência em dois dos estudos com amostras coletadas nesse período.…”