Prevalence of rhesus negativity among pregnant women

Nagamuthu, Ezhil Arasi; Mudavath, Padmavathy; Prathima, Pasupuleti; Bollipogu, Srilatha

doi:10.18203/2320-6012.ijrms20162284

Cited by 7 publications

(8 citation statements)

References 2 publications

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“…19 This finding was lower than a study conducted in Turkey showing that the prevalence was 10.4% negative, 28 7.94% in the Silte zone, 29 and 8.8% from Mekelle. 17 However, this finding was higher than those of studies conducted in Nigeria, where 5.5% women were Rh D-negative, 30 4.29% in India, 31 1.68% in Nepal, 32 0.31% from Rajavithi Hospital, 33 and 2.9% in Bangalore India. 34 The variations among the studies might be due to the difference in sample size, laboratory method applied for Rh-negative determination, and difference in ethnicity.…”

Section: Discussionmentioning

confidence: 83%

“…34 However, this finding was lower than that previously reported from India, blood group B 33.96% and blood group O 32.62%, but much higher than blood group A and AB reported 24.35% and 9.05%, respectively. 31 The difference could be due to blood group O being the predominant blood group among the African population compared to other continents.…”

Section: Discussionmentioning

confidence: 99%

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Rhesus Negativity Prevalence and Neonatal Outcomes among Pregnant Women Delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia

Aliyo

Ashenafi

Abduselam

2023

Clin Med Insights Pediatr

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Background: Rh incompatibility has been an important cause of severe neonatal hyperbilirubinemia, hydrops fetalis, and stillbirth. Among those outcomes, neonatal jaundice is the most common problem. Objective: The study is assessed the prevalence of Rhesus (Rh) negativity and neonatal outcomes among pregnant women who delivered at Bule Hora University Teaching Hospital over a 5-year period from January 2017 to December 31, 2022. Methods: A retrospective study was conducted on 110 women who delivered at Bule Hora University Teaching Hospital (BHUTH) from January 2017 to December 31, 2021. The complete data of the mother’s and neonates’ status were extracted from the registration book of the hospital using checklists. The data were double entered using EpiData version 3 and exported to the Statistical Package for Social Sciences (SPSS) version 26 for analysis. Descriptive statistics to determine prevalence and frequencies were used to describe the study population in relation to relevant variables, and the results are presented in tables and charts. Results: The study shows that the prevalence of Rh D-negative among women who delivered was 6.4% [95% CI: 1.83,10.98]. Among Rh-negative women, 1 (25%) of blood group AB, 3 (6.5%) of blood group O, and 2 (6.1%) of blood group A were Rh-D negative. The distributions of O, A, B, and AB blood groups among pregnant women who delivered this hospital were 41.8%, 30%, 24.6%, and 3.6%, respectively. Out of neonates born to Rh-negative women, 1 (14.3%) was born with jaundice. Of women who delivered at BHUT hospital, 61 (55.5%) did not have a previous delivery, 7 (6.4%) had a previous abortion, 5 (4.5%) stillbirth, 1 (0.9) died after birth, 4 (3.6%) had a birth child weight less than 2.6 kg. Conclusion: The study revealed that the prevalence of Rh-negative was comparable with finding of different similar studies. To reduce Rh incompatibility-related HDN, the government should educate mothers and encourage them as they follow ANC facilities and after delivery to health facilities.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Rhesus Negativity Prevalence and Neonatal Outcomes among Pregnant Women Delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia

Aliyo

Ashenafi

Abduselam

2023

Clin Med Insights Pediatr

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“…An interviewer-administered, pretested structured questionnaire was used to collect data on socio-demographic variables such as age, marital status, educational status, occupation, and religion of the participants ( 3 , 8 , 14 , 20 , 22 ). The wording and sequence of questions were designed in such a way that the sequence of ideas (from general to specific and from easy to difficult questions) was maintained.…”

Section: Methodsmentioning

confidence: 99%

“…The Rhesus antigen is a protein found on the surface of the membrane of human red blood cells. Isoimmunization occurs when a person is immunized with an antigen derived from a similar subject if the antigen was previously absent ( 2 , 3 ). If a mother is Rh-D negative and the fetus is Rh-D positive, she may develop antibodies if exposed to fetal antigens from the Rh-D positive fetus and this process labeled to be as Rh-D sensitization ( 2 , 4 – 7 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and determinants of RH alloimmunization in Rh-negative women in teaching hospitals of Addis Ababa, Ethiopia: a hospital-based cross-sectional study

Maruta,

Tesfaye,

Birhanu

et al. 2023

Front. Glob. Womens Health

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BackgroundDespite the implementation of immunization with an anti-D antigen for pregnant women, adverse pregnancy outcomes continue to occur in Ethiopia and most Sub-Saharan African countries. Consequently, the woman's obstetric care is compromised, and there is an increase in perinatal morbidity and mortality. In Ethiopia, the burden of the disease is not well understood, and no research has been conducted in the study area. Therefore, this study aims to determine the prevalence and determinants of Rh alloimmunization in Rh-negative women receiving care at Addis Ababa teaching hospitals.MethodsAn institutional-based cross-sectional study was conducted from 5 October 2020 to 5 May 2021, among 328 Rh-negative pregnant women who received antenatal care and delivery services at Teaching Hospitals under Addis Ababa University. Face-to-face interviews were used to gather data using a pre-tested structured questionnaire, and a chart review was performed using a checklist. The data were entered into Epidata version 3.1 and analyzed using SPSS version 22. Multivariable analysis and logistic regression were used to evaluate the predictors, and the results were presented as an adjusted odds ratio (AOR) with a 95% confidence interval. Statistical significance was declared at a p-value < 0.05.ResultsAmong Rh-D negative individuals, 56(17.1%) were alloimunized with 95% CI (15.1%, 19.23%). The prevalence of Rh-D negative was 2.1% with 95% CI (1.56%, 2.76%). Factors such as unemployment [AOR = 2.28, 95% CI: 1.21, 4.28], failure to use anti-D prophylaxis in previous pregnancy [AOR = 2.08, 95% CI: 1.10, 3.92), and the presence of sensitizing events [AOR = 0.52, 95% CI: 0.27, 0.84] were statistically significant with the outcome variables.ConclusionsThis study pointed out that the prevalence of Rh was relatively large and that almost one in every five pregnant women was alloimunized. Factors such as unemployment and failure to use anti-D prophylaxis in a previous pregnancy were found to be associated with outcome variables. Therefore, all stakeholders and concerned entities should prioritize enhancing access and affordability to anti-D prophylaxis to prevent the occurrence of Rh alloimmunization and its associated adverse outcomes.

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“…To overcome such fetal danger, anti-D injection is required for the mother within 72 hours after the first delivery. The anti-D injection will help the mother to get rid of any blood that has leaked from the first fetus during childbirth so that her blood will not produce antibodies, which could affect the next pregnancy [20][21][22][23][24].…”

Section: Blood Group Test For Newly Married Couplesmentioning

confidence: 99%

Effect of Rhesus factor incompatibility on maternal outcome (fertility): A comprehensive review

Eric Omo Irinmwinuwa,

Chikodili Adolphus Mbah,

Godwin Bernard Oyate

et al. 2023

Int. J. Front. Life Sci. Res.

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Rh incompatibility, also known as Rh disease, is defined as a condition that occurs when a woman with Rh-negative blood type is exposed to Rh-positive blood cells, leading to the development of Rh antibodies. The incidence of occurrence is more frequently among those of Caucasian (North American and European) descent (15% to 17%) compared to those of African (4% to 8%) or Asian descent (0.1% to 0.3%). Worldwide, the prevalence of Rh disease is estimated to be 276 per 100,000 live births, which is significant considering that an estimated 50% of untreated cases of haemolytic disease of the neonate (HDN). HDN will either die or develop brain damage due to the disease. The condition is due to: If a Rhesus negative (Rh-) woman is impregnated by a man with Rhesus negative (Rh-) there wouldn’t be any problem. If a Rhesus negative woman (Rh-) is impregnated by a man with Rhesus positive (Rh+) and the baby inherited the rhesus positive (Rh+) from the father there will be a problem or when an Rh-negative mother is exposed to the Rh D antigen, the D antigen is perceived as a foreign threat leading to the haemolysis of the fetal erythrocytes, common signs and symptom include; Jaundice, a yellowing of the skin and whites of the eyes, lethargy, heart failure, enlarged organs. It can be prevented and treated by administering an injection of RhoGAM during the second trimester, and 28th week of pregnancy respectively, exchange transfusions either before birth or after delivery. Phototherapy is also another treatment modality which break down excess bilirubin into less toxic substance that the new borns liver can remove.

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Prevalence of rhesus negativity among pregnant women

Cited by 7 publications

References 2 publications

Rhesus Negativity Prevalence and Neonatal Outcomes among Pregnant Women Delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia

Rhesus Negativity Prevalence and Neonatal Outcomes among Pregnant Women Delivered at Bule Hora University Teaching Hospital, West Guji Zone, South Ethiopia

Prevalence and determinants of RH alloimmunization in Rh-negative women in teaching hospitals of Addis Ababa, Ethiopia: a hospital-based cross-sectional study

Effect of Rhesus factor incompatibility on maternal outcome (fertility): A comprehensive review

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