Prevalence of retinopathy of prematurity: an institutional cross-sectional study of preterm infants in Brazil

Filho, João Borges Fortes; Eckert, Gabriela Unchalo; Valiatti, Fabiana Borba; Costa, Marlene Coelho da; Bonomo, Pedro Paulo; Procianoy, Renato S.

doi:10.1590/s1020-49892009000900005

Cited by 15 publications

(16 citation statements)

References 12 publications

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“…Many ROP studies screened only infants born with less than 32 weeks’ gestation or with less than 1500 g of BW [ 4 , 11 ]. In our study, however, we went further and also included infants with more than 1500 g or more than 32 weeks’ gestation with determined risk factors associated.…”

Section: Discussionmentioning

confidence: 99%

“…The incidences of ROP at any stage and of type 1 prethreshold ROP in this subgroup were at intermediate levels of the range reported in Brazilian studies that used the same selection criteria. Fortes Filho et al [ 4 ] found an incidence of ROP at any stage and of type 1 prethreshold ROP of 29.6 and 7% respectively. Conversely, Gonçalves et al [ 11 ] found an incidence of ROP at any stage and of type 1 prethreshold ROP of 44.5 and 1.8% respectively.…”

Section: Discussionmentioning

confidence: 99%

“…These increased numbers may be attributed to improved perinatal care. The high rates are leading to a significant raise in the occurrence of other comorbidities related to preterm birth [ 4 ] that have major social repercussion, such as blindness secondary to ROP. Worldwide, nearly 10% of all births are premature (before 37 weeks’ gestation) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study

et al. 2018

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Background and objectivesAdvances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incidence of ROP and evaluates potential risk factors associated.MethodsA retrospective cohort study of preterm infants born in a tertiary neonatal intensive care unit was conducted from March 2005 to August 2015. Six hundred and thirty-nine newborns were included based on the following criteria: infants born with less than 32 weeks’ gestation or birth weight below 1500 g; or neonates born with 32–37 weeks’ gestation or birth weight above 1500 g and any of the following associated: multiple gestation, respiratory distress syndrome, sepsis, blood transfusions or intraventricular hemorrhage. Neonates were followed up until disease resolution or until treatment criteria was achieved.ResultsA total of 602 newborns were evaluated after applying the exclusion criteria. Mean gestational age was 30.7 ± 2.5 weeks. The incidences of ROP at any stage and of type 1 prethreshold ROP were 33.9 and 5.0% respectively. Logistic regression analysis revealed that risk factors associated with ROP at any stage were extremely low birth weight (ELBW) (odds ratio [OR] = 3.10; 95% confidence interval [95% CI]:1.73–5.55), pulmonary diseases (OR = 2.49; 95% CI: 1.35–4.59), intraventricular hemorrhage (OR = 2.17; 95% CI: 1.10–4.30), and low gestational age (OR = 0.81; 95% CI: 0.73–0.91). The main risk factors associated with type 1 prethreshold ROP were pulmonary diseases (OR = 9.58; 95% CI: 1.27–72.04) and ELBW (OR = 3.66; 95% CI: 1.67–8.00).ConclusionThis study found a significant incidence of ROP (33.9%) in the studied population, and highlighted pulmonary diseases as a significant risk factor for type 1 prethreshold ROP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study

et al. 2018

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“…Neovascularization in the retina due to ROP is similar to retinopathies, such as diabetic retinopathy 45. The incidence of ROP varies considerably from country to country depending on the economy, social conditions, and the quality of the infant health care system 6–8. Previous studies have reported an increase in the incidence of blindness, visual loss, and impairment due to ROP 9.…”

Section: Introductionmentioning

confidence: 99%

Incidence of retinopathy of prematurity and risk factors in the South-Western Region of Iran

Feghhi

Altayeb

Haghi

et al. 2012

Middle East Afr J Ophthalmol

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Aims:The aim of this study was to report the incidence of retinopathy of prematurity (ROP) and the contribution of various risk factors to ROP in the south-western region of Iran.Material and Methods:This cross-sectional case-control series reviewed all low birth weight (LBW, ≤2000 g) neonates and/or neonates less than 32 weeks gestational age who had been hospitalized in the Neonatal Intensive Care Unit from 2006 to 2010. The cohort was divided into infants without ROP (nonROP group) and infants with ROP (ROP group). Infants were first examined by a group of pediatric ophthalmologists 6 weeks after delivery, and then were followed every 1-2 weeks until death, discharge or complete retinal avascularization. If an infant developed ROP, further examinations were performed based on the Early Treatment for Retinopathy of Prematurity Study protocol. Demographic data, medical treatment, and ophthalmic disorders were all statistically analyzed.Results:A total of 576 infants met the criteria for evaluation. Of 576 total patients, 183 infants (32%) (88 males, 95 females) had ROP. There were significant differences between groups in gestational age, body weight, and duration of oxygen administration, and sepsis (P<0.05). Male/female ratio, single and multiple births, and jaundice, phototherapy, and blood transfusion were not significant. The majority of ROP was stage I or II (137, 74.8%). Stage III or greater developed in 46 infants (25.1%) [Note: The ocular history and ocular outcomes are not risk factors.]Conclusions:The incidence of ROP in this study is higher than that in other parts of the world. Awareness and knowledge of ROP and its relative risks need to be reinforced in ophthalmologists and other health practitioners.

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“…No Brasil, a incidência de retinopatia apresenta uma ampla variação entre os diversos serviços, situando-se em torno de 25 a 29% em Porto Alegre 19 e São Paulo 20,21 , e chegando até a taxa de 63% em um serviço de neonatologia na cidade de Natal (RN) 22 , considerando-se RNs com peso de nascimento menor de 1500 gramas.…”

Section: Introductionunclassified

Efeitos biomoleculares do JB-1 (um peptídeo análogo do IGF-1) em um modelo experimental de retinopatia induzida por oxigênio em ratos

Zacharias¹

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Prevalence of retinopathy of prematurity: an institutional cross-sectional study of preterm infants in Brazil

Abstract: Overall incidence of ROP in this institutional study (25.5%) was comparable to international results from developed countries. A comprehensive countrywide survey on ROP in Brazil is recommended to determine any regional differences in disease prevalence.

Cited by 15 publications

References 12 publications

Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study

Incidence and risk factors for retinopathy of prematurity: a retrospective cohort study

Incidence of retinopathy of prematurity and risk factors in the South-Western Region of Iran

Efeitos biomoleculares do JB-1 (um peptídeo análogo do IGF-1) em um modelo experimental de retinopatia induzida por oxigênio em ratos

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