Prevalence of retinopathy in Caucasian type 2 diabetic patients from the South of Brazil and relationship with clinical and metabolic factors

Santos, Kátia Gonçalves dos; Tschiedel, Balduíno; Schneider, J.; Souto, Kátia Elisabete Pires; Roisenberg, Israel

doi:10.1590/s0100-879x2005000200010

Cited by 15 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The risk of Diabetic Retinopathy increases by 1.89 times for every 5-year increase in the duration of diabetes mellitus. 13 K. G Santosh et al, have shown that glycosylated hemoglobin, MA and the duration of diabetes mellitus were independently related to DR. 14 In our research study, HbA1c and MA in diabetic patients with DR were positively correlated, which was similar to the findings reported by some previous study. [15][16][17][18] In another study, there was no significant association of MA with HbA1c, but there was a strong association with fasting blood glucose, which was similar to an earlier study.…”

Section: Discussionsupporting

confidence: 92%

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

2020

IJCBR

View full text Add to dashboard Cite

Introduction: Diabetes Mellitus is one of the most common metabolic disorders, resulting in hyperglycemia and is associated with micro and macro vascular complications. Diabetic retinopathy (DR) is a widely accepted cause of blindness in adults. The duration of diabetes, glycemic control and microalbuminuria (MA) have been implicated in the onset and progression of DR. Materials and Methods: The aim of our study is to correlate FBS, PPBS, HbA1c and microalbuminuria with diabetic retinopathy and to find out MA as the predictor of DR in T2DM patients. Our study included, 50 T2DM patients with DR, 50 T2DM patients without DR and 50 controls of both sex in the age group of 40 -60 years. Fasting blood sugar (FBS) and post prandial blood sugar (PPBS) were estimated by Glucose Oxidase method, glycated hemoglobin (HbA1c) by Ion Exchange Resin Method and urine samples were assayed for Microalbumin by Immunoturbidimetric assay and DR was diagnosed using Fundoscopy. Results: In our study, levels of urinary microalbumin, FBS, PPBS and HbA1c in T2DM patients with DR is increased than T2DM patients without DR than the control group, which is highly significant (p <0.001). HbA1c and Microalbuminuria in T2DM are positively correlated. All the parameters (FBS, PPBS, HbA1c and microalbuminuria) in group A cases are positively correlated with grades of Diabetic Retinopathy. Conclusion: Microalbuminuria and diabetic retinopathy are closely associated in T2DM patients and is a reliable marker which can predict the risk for the development of DR. All patients with MA should undergo regular retinal evaluation.

show abstract

Section: Discussionsupporting

confidence: 92%

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

2020

IJCBR

View full text Add to dashboard Cite

show abstract

“…According to the Data are shown as mean ± standard deviation (SD). Group 2: diabetic patients without DR, Group 3: diabetic patients with DR P \ 0.05 is significant abundant literature, duration of diabetes, severity of hyperglycaemia and poor control of blood pressure are the major risk factors that accelerate development of the disease (Klein et al 1984;Tapp et al 2003;Fong et al 2004;Manaviat et al 2004;Santos et al 2005). Glycemic control remains the main parameter on which we can act to prevent or at least delay the apparition of microvascular complications of diabetes (Altannavch et al 2004;Fong et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The duration of diabetes and the severity of hyperglycemia are the major risk factors that accelerate development of the disease (Klein et al 1984;Tapp et al 2003;Fong et al 2004;Santos et al 2005). DR progresses through various stages from non-proliferative diabetic retinopathy (NPDR) to proliferative diabetic retinopathy (PDR).…”

Section: Introductionmentioning

confidence: 99%

Apoptotic factors (Bcl-2 and Bax) and diabetic retinopathy in type 2 diabetes

2010

View full text Add to dashboard Cite

The expression of apoptotic factors Bcl-2 and Bax were studied in the conjunctiva of diabetic patients with and without retinopathy. All patients underwent a complete ophthalmic examination including ocular fundus and retinal fluorescein angiography. The indirect immunoperoxidase method was performed on 15 normal conjunctiva taken during cataract surgery (group 1), on 40 eyes of 40 patients with type 2 diabetes without diabetic retinopathy (group 2) and 13 eyes of 13 patients with diabetic retinopathy (group 3). In normal human conjunctiva, Bax showed positive expression in epithelial, vascular and stromal cells whereas Bcl-2 staining was negative. In the conjunctiva of diabetic patients without diabetic retinopathy, Bax was widely, and strongly, expressed in epithelial cells, vascular endothelial cells, fibroblasts and infiltrating cells such as macrophages. For patients with diabetic retinopathy, Bax was consistently strong to very strong. Bcl-2 protein expression became weak to negative for diabetic patients both with and without diabetic retinopathy. Immunoreactivity was not correlated between Bcl-2 and Bax in the conjunctiva of diabetic patients. Bax was always localized in tissues characterized by a high rate of apoptosis, whereas, Bcl-2 was absent. Our results suggest that diabetic human conjunctiva, with its inflammatory phenomena, is considered as a privileged target for programmed cell death.

show abstract

“…Consequently, hyperglycaemia plays a determinant role in DR emergence (Altannavch et al 2004;Manaviat et al 2004;Santos et al 2005;Stitt et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…The multisystem complications of diabetes such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases are considered important issues in public health (Manaviat et al 2004). Diabetic retinopathy (DR) is a common complication of diabetes and despite the availability of effective treatment, it remains one of the leading causes of vision loss (Joussen et al 2002a, b;Tapp et al 2003;Abu-El-Asrar et al 2004;Cheung et al 2005;Santos et al 2005). Although progress has been made in the last decade in understanding the molecular mechanisms of DR, the disease is still neither preventable nor curable (Chen et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

2007

View full text Add to dashboard Cite

The expression of intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) were studied in the conjunctiva of diabetic patients with and without retinopathy. All patients underwent a complete ophthalmic examination including ocular fundus and retinal fluorescein angiography. The indirect immunoperoxidase method was performed on 15 normal conjunctivas taken during cataract surgery (group 1), on 40 eyes of 40 patients with type 2 diabetes without diabetic retinopathy (DR) (group 2) and 13 eyes of 13 patients with DR (group 3). ICAM-1 and VCAM-1 are located in epithelial cells, vascular endothelial cells and in stromal cells. Our results show a statistically significant increase in the immunohistochemical expression of these proteins in the conjunctiva of diabetic patients with and without DR in comparison with normal conjunctiva (P = 0.001). Noteworthy, ICAM-1 and VCAM-1 are upregulated in the conjunctiva of diabetic patients with and without retinopathy, reflecting the inflammatory nature of this condition and suggesting a possible role for these mediators in the pathogenesis of diabetic microangiopathy.

show abstract

Prevalence of retinopathy in Caucasian type 2 diabetic patients from the South of Brazil and relationship with clinical and metabolic factors

Cited by 15 publications

References 20 publications

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus

Apoptotic factors (Bcl-2 and Bax) and diabetic retinopathy in type 2 diabetes

Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

Contact Info

Product

Resources

About