Prevalence of restless legs syndrome and quality of sleep in type 2 diabetics

<p>Sleep Quality and Associated Factors Among Diabetes Mellitus Patients in a Follow-Up Clinic at the University of Gondar Comprehensive Specialized Hospital in Gondar, Northwest Ethiopia: A Cross-Sectional Study</p>

“…41 This might be due to comorbidities resulting in poor glycemic control, more chronic complications and increased emotional disorder which can result in disturbed hemostasis and poor sleep quality. 59 Having depression was 9.93 times more likely to result in poor sleep quality as compared with not reporting depressive symptoms. This finding was similar to studies conducted in Norway, 60 China, 61 and India.…”

Association between restless legs syndrome and peripheral neuropathy: A systematic review and meta‐analysis

“…• None of the parameters studied showed a significant correlation with RLS severity. These results suggest that abnormal sensory perception in iRLS could be related to an alteration of central somatosensory processing instead of small fibre abnormalities [32,34,[42][43][44][45] the other four did not find significant differences [31,36,38,39] although the meta-analysis showed a significantly higher frequency of PN/ PNP in patients with RLS. The prevalence of RLS in patients with DM2 has been reported to be higher [34,36,43] or similar [30,31] compared with 'controls' suffering from other (inactive) endocrine diseases, but the results of the meta-analysis finally revealed an increased risk for RLS in patients diagnosed with DM2.…”

“…The frequency of RLS in patients with diabetic PN/PNP ranged from 10.6% to 40.3% [32–44] being 27.0% (95% CI 23.9%–30.2%) according to the pooled data (Figure 3c). Finally, the frequency of PN/PNP in patients with DM2 and RLS ranged from 14.6% to 92.6% (37.4% with 95% CI 33.2%–41.5% for pooled data) [31,32,34–36,38,39,41–44] (Figure 3d) and was significantly higher than that found in patients with DM2 who did not have RLS [31,32,34,36,38,39,42–44] (Figure 3e; funnel plot shown in Figure S12). After excluding those studies that did not use the 1995 [16] 2003 [17] or 2014 [18] IRLSSG diagnostic criteria for RLS, and/or did not confirm the presence of PN/PNP by neurophysiology [30,31,32,34,36,41–44], the prevalence of RLS in patients with diabetic PN/PNP was 15.2%–33.3% (mean 25.2%, 95% CI 21.1%–29.3%) (Figure 3f).…”

“…The prevalence of RLS in DM2 patients found in studies with different designs ranges from 8.0% to 28.3% (mean 15.5%, 95% CI 14.3%–16.7% according to pooled data, Figure 3a) and, according to this meta‐analysis, has been found to be significantly higher than that found in controls [30,31,34,36,43] (Figure 3b). The frequency of RLS in patients with diabetic PN/PNP ranged from 10.6% to 40.3% [32–44] being 27.0% (95% CI 23.9%–30.2%) according to the pooled data (Figure 3c). Finally, the frequency of PN/PNP in patients with DM2 and RLS ranged from 14.6% to 92.6% (37.4% with 95% CI 33.2%–41.5% for pooled data) [31,32,34–36,38,39,41–44] (Figure 3d) and was significantly higher than that found in patients with DM2 who did not have RLS [31,32,34,36,38,39,42–44] (Figure 3e; funnel plot shown in Figure S12).…”

“…The prevalence of RLS in patients with DM2 has been reported to be higher [34,36,43] or similar [30,31] compared with 'controls' suffering from other (inactive) endocrine diseases, but the results of the meta-analysis finally revealed an increased risk for RLS in patients diagnosed with DM2. The frequencies of RLS reported in patients with diabetic PN (mean 27.0%, 95% CI 23.9%-30.2%) according to pooled data from nine studies [32][33][34][36][37][38]40,42,44] were higher than those described in patients with osteoarthritis in one study [37]. None of the studies reported on the association between RLS and DM/DM2 assessed small fibre involvement.…”