Prevalence of restless legs syndrome in people with diabetes mellitus: A pooling analysis of observational studies

Ning, Pingping; Mu, Xin; Yang, Xinglong; Tian, Li; Xu, Yanming

doi:10.1016/j.eclinm.2022.101357

Cited by 17 publications

(16 citation statements)

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“…In this systematic review, all included studies used relevant diagnostic criteria. However, as our meta-analysis is based on studies from 2000 to 2022, and small changes have been made during this period regarding the diagnostic definition (i.e., 2003 andAllen et al, 2014) (e.g., linked to alcohol abuse, and vitamin B12 deficiency) have been associated with high prevalence rates of RLS (Gupta et al, 2021;Huang et al, 2020;Jiménez-Jiménez et al, 2021;Ning et al, 2022;Ozdogar & Kalron, 2021). Furthermore, side-effects of specific pharmacotherapy (e.g., neuroleptics, antidepressants, anti-epileptics, lithium, and antihistamines) can induce or worsen RLS symptoms (Allen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The fifth criterion implies a greater emphasis on differentiating other conditions that mimic RLS (e.g., leg cramps or arthritic pain in lower limbs), which decreases the risk of misdiagnosis. Several comorbidities or conditions, such as end‐stage renal disease, chronic liver disease, multiple sclerosis, diabetes mellitus, iron deficiency, and polyneuropathy (e.g., linked to alcohol abuse, and vitamin B12 deficiency) have been associated with high prevalence rates of RLS (Gupta et al, 2021; Huang et al, 2020; Jiménez‐Jiménez et al, 2021; Ning et al, 2022; Ozdogar & Kalron, 2021). Furthermore, side‐effects of specific pharmacotherapy (e.g., neuroleptics, antidepressants, anti‐epileptics, lithium, and antihistamines) can induce or worsen RLS symptoms (Allen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…As indicated in the criteria, RLS may be secondary to several other diseases or conditions. Meta‐analyses of the prevalence of RLS in relation to specific diagnoses and conditions indicate high prevalence rates for end‐stage renal disease (Huang et al, 2020), chronic liver disease (Gupta et al, 2021), multiple sclerosis (Ozdogar & Kalron, 2021), diabetes mellitus (Ning et al, 2022), peripheral neuropathy (Jiménez‐Jiménez et al, 2021), migraine (Ghasemi et al, 2020), and for pregnant women in the third trimester (Darvishi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Worldwide estimation of restless legs syndrome: a systematic review and meta‐analysis of prevalence in the general adult population

Broström

Alimoradi

Lind

et al. 2023

Journal of Sleep Research

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This systematic review, meta-analysis and meta-regression assessed the prevalence of restless legs syndrome (RLS) in the general adult population. Studies identified in Scopus, PubMed, Web of Science, and PsycInfo between January 2000 and February 2022 were included if they used a case-control or cross-sectional design and reported data regarding the prevalence of RLS. The protocol was pre-registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022300709). A total of 97 studies including 483,079 participants from 33 different countries met the eligibility criteria. The Newcastle Ottawa Scale was used to evaluate the methodological quality, and the fill-and-trim method was used to correct probable publication bias, while the jack-knife method was performed to assess small study effect. The corrected overall pooled prevalence of RLS was 3% (95% confidence interval [CI] 1.4%-3.8%). The pooled prevalence of RLS syndrome was affected by methodological quality (no data from non-respondents in the included studies), gender (higher among women), study design (lower prevalence in casecontrol versus cohort and cross-sectional studies). The figures for corrected pooled prevalence among men, women, alcohol consumers and smokers were 2.8% (95% CI 2%-3.7%); 4.7% (95% CI 3.2%-6.3%); 1.4% (95% CI 0%-4.2%); and 2.7% (95% CI 0%-5.3%), respectively. The prevalence among male and female participants was lower in community-based versus non-community-based studies. Moreover, the prevalence was higher in developed versus developing countries and among elders versus adults. In conclusion, RLS is a common disorder in the general adult population, with a higher prevalence in women; however, prevalence data are affected by study design and quality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Worldwide estimation of restless legs syndrome: a systematic review and meta‐analysis of prevalence in the general adult population

Broström

Alimoradi

Lind

et al. 2023

Journal of Sleep Research

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“…36,37 Possible pathophysiological mechanisms may be attributed to peripheral neuropathy due to small-fiber neuropathy, which increases the risk of restless legs syndrome, which is commonly reported among individuals with diabetes mellitus. 38,39 Pain from common complications, such as peripheral neuropathy or nocturia from poor glycemic control, 40 and a periodic breathing pattern during sleep, which is more common among those with diabetes, may further impact the sleep quality of individuals. 40 The effectiveness of the Mediterranean diet in reducing excessive daytime sleepiness requires further elaboration.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Mediterranean Diet on Daytime Sleepiness among Individuals with Type 2 Diabetes Mellitus in Oman

AlAufi,

Chan,

Chin

et al. 2024

Sleep Sci

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Background Sleep disturbance is a major complaint among individuals with diabetes mellitus and may be augmented by dietary interventions. The objective of this randomized controlled trial was to determine the effectiveness of a Mediterranean diet intervention on daytime sleepiness among individuals with type 2 diabetes mellitus (T2DM) in Oman. Methods In total, 134 eligible individuals with T2DM (61 and 73 participants in the intervention and control groups, respectively) were recruited. The intervention participants underwent a 6-month Mediterranean diet intervention consisting of individual dietary counseling, cooking classes, phone calls, and social media messages, while the control group continued with standard diabetes care. Daytime sleepiness was assessed using the Epworth Sleepiness Scale. All data was analyzed using IBM SPSS Statistics for Windows, version 26.0 (IBM Corp., Armonk, NY, USA). Results Daytime sleepiness was evident, with ∼ 30% of the participants experiencing it, with no significant difference between control and intervention participants at baseline. There was a significant reduction in daytime sleepiness in both the intervention and control groups after 6 months, with daytime sleepiness significantly lower in the intervention group, with a modest difference of 42.56% (p < 0.001). Conclusion Adherence to the Mediterranean diet is effective in reducing daytime sleepiness among individuals with T2DM. Clinical Trial UMIN000041152

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“…This meta-analysis was registered in INPLASY platform (202240032). The methodology is referred to previous publications (12)(13)(14)(15)(16).…”

Section: Search Strategymentioning

confidence: 99%

Association of vitamin A supplementation with immune-related allergic diseases: A meta-analysis

Li²,

Hua³

2022

Front. Nutr.

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BackgroundAllergic diseases are type I hypersensitivity reactions mediated by various allergens. The most common allergic diseases include allergic rhinitis, allergic asthma, allergic dermatitis, and allergic conjunctivitis. The incidence of allergic diseases has been increasing in the recent past, and allergen avoidance and adoption of desensitization treatment can significantly decrease the incidence of allergic diseases. Previous studies have explored the association between vitamin A supplementation and allergic diseases; however, the results are inconsistency. The aim of the present study was to evaluate the association between vitamin A supplementation and allergic diseases, with a focus on atopy and wheezing.MethodsArticles reporting randomized controlled trials (RCTs) on the association of vitamin A supplementation and allergic diseases were retrieved from PubMed, Embase, Web of science, and China National Knowledge Infrastructure database from inception of to November 15, 2021. STATA 12.0 software was used for meta-analysis, sensitivity analysis and analysis of publication bias.ResultsSeven studies comprising 2201 participants met the inclusion criteria and were included in the meta-analysis. The findings showed that vitamin A supplementation was associated with increased risk of atopy in young females compared with the placebo [RR = 1.70, 95% confidence interval (1.20, 2.41), P = 0.171, I2 = 43.4% fixed effect model]. The frequency of delayed atopy among adults was associated with vitamin A supplementation (MD = 0.46, 95% CI = 0.04, 0.88). Analysis showed no significant association between vitamin A supplementation with incidence of wheezing in children [RR = 1.40, 95% CI (0.49, 3.98), P = 0.018, I2 = 82.1% random effect model]. Sensitivity and publication bias analysis showed that each individual study did not affect the combined results and there was no significant publication bias among the studies.ConclusionThe findings showed that vitamin A supplementation is associated with increased risk of atopy but no correlation was observed with the incidence of wheezing. The results of this meta-analysis provide evidence for effective management of fibrosis. More studies should be conducted to verify the results.

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Prevalence of restless legs syndrome in people with diabetes mellitus: A pooling analysis of observational studies

Cited by 17 publications

References 71 publications

Worldwide estimation of restless legs syndrome: a systematic review and meta‐analysis of prevalence in the general adult population

Worldwide estimation of restless legs syndrome: a systematic review and meta‐analysis of prevalence in the general adult population

Effectiveness of Mediterranean Diet on Daytime Sleepiness among Individuals with Type 2 Diabetes Mellitus in Oman

Association of vitamin A supplementation with immune-related allergic diseases: A meta-analysis

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