Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies

Yang, Xinglong; Liu, Bin; Shen, Hao; Li, Shimei; Zhao, Quanzhen; An, Ran; Hu, Fayun; Ren, Hui; Xu, Yanming; Xu, Zhenhe

doi:10.1016/j.sleep.2017.11.1146

Cited by 56 publications

(37 citation statements)

References 40 publications

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“…Many previous studies have focused on the effects of a single type of sleep disorder on PD [9][10][11][12][13] . It is worth noting that PD patients may have multiple comorbid sleep disorders that require attention.…”

Section: Introductionmentioning

confidence: 99%

Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients

Zhang

Zhao

Huang

et al. 2020

npj Parkinsons Dis.

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Sleep disorders are common non-motor symptoms in patients with Parkinson’s disease (PD). The characteristics and impact of multiple comorbid sleep disorders remain to be elucidated. Our goal was to investigate the characteristics of various sleep disorder comorbidities, and their association with motor complications and the impact on the quality of life in PD patients. In this multicenter, observational, cross-sectional study, data concerning the clinical characteristics of complicated sleep disorders were collected from PD patients treated at 40 different hospitals in Shanghai. Sleep disorders were evaluated using the PD Sleep Scale-2, Epworth Sleepiness Scale, Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong, and the International Restless Legs Scale. Among the 1006 subjects evaluated, 77.53% exhibited signs of sleep disorders, and most had multiple sleep disorders (n = 502, 49.9%). A smaller percentage of patients with sleep disorders had a single disorder (n = 278, 27.6%). Furthermore, an increased number of sleep disorders, including nighttime problems, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, and restless legs syndrome was a significant contributor to a poor quality of life (β = 4.33, CI: 3.33–5.33, P for trend <0.001), even when controlling for multiple factors. Moreover, motor complications partially mediated this relationship (indirect effect: β = 0.355, 95% boot CI: 0.134, 0.652).Our study showed that a large proportion of PD patients suffer from multiple comorbid sleep disorders, which greatly decreases the quality of life in PD patients and is partially mediated by motor complications.

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Section: Introductionmentioning

confidence: 99%

Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients

Zhang

Zhao

Huang

et al. 2020

npj Parkinsons Dis.

View full text Add to dashboard Cite

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“…The authors found a relatively higher prevalence in females (13%) than in males (11%). [19] The prevalence of LLS in MS patients ranged from 17.3% to 29.1% in our systematic review. [20][21][22]…”

Section: Nosdmentioning

confidence: 73%

“…The prevalence of spasticity in PD patients ranges from 0% to 38%. [19] There is an association between LLS and falls. A study conducted on MS patients found that the severity of knee flexors and ankle plantar flexors spasticity was significantly higher in the fallers compared to non-fallers.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Burden of Lower Limb Spasticity in Adults: A Systematic Review

Javed¹,

Ali²

2019

J Med Res Innov

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Objective: The objective of this study was to investigate the burden of disease associated with lower limb spasticity (LLS) and its complications in adults. Methods: A systematic search of MEDLINE and EMBASE identified 9 studies published between November 2012 and July 2019 that assessed the epidemiological burden associated with LLS. Results: LLS was found to occur in one-third of adults after neuromyelitis optica spectrum disorder (NMOSD), one quarter to one third with multiple sclerosis, one quarter to half with Parkinson’s disease and roughly half with stroke. LLS reduces mobility and diminishes the quality of life. LLS complications, especially injuries following falls are a common occurrence. Conclusion: Given the high prevalence among adults with common disorders, such as stroke; the evidence on the burden of LLS is somewhat finite. Further research is needed to explore the trends over time and across different geographical regions in the incidence and prevalence of LLS. The dearth of high-quality evidence for LLS suggests a lack of awareness of the problem and interest in it, and hence, the unmet need among patients and their carers.

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“…RLS and PLMS often co-exist and are highly prevalent in PD [14,71], with RLS affecting around 30% of patients [39]. RLS is characterised by a marked urge to move (particularly the legs), typically in the evening and during periods of rest and inactivity, which is relieved by moving and only returns when the movement stops.…”

Section: Spectrum Of Sleep Disorders In Pdmentioning

confidence: 99%

New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson’s disease

Keir

Breen

2019

J Neurol

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The non-motor features of Parkinson's disease (PD) are increasingly being recognised. This review deals with the spectrum of sleep disorders associated with PD, which have a multifactorial aetiology and can significantly have an impact on the quality of life of patients and their carers. Some sleep disorders represent a prodromal phase of PD, with REM sleep behaviour disorder (RBD) being of particular interest in this regard, whereas others become more common as the disease advances. Understanding the pathophysiology of these sleep disturbances will hopefully lead to new treatment opportunities in the future. The recent discovery of the glymphatic system for removal of waste products from the brain has also raised the possibility that sleep disruption may cause or accelerate the underlying disease process.

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Prevalence of restless legs syndrome in Parkinson's disease: a systematic review and meta-analysis of observational studies

Cited by 56 publications

References 40 publications

Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients

Multiple comorbid sleep disorders adversely affect quality of life in Parkinson’s disease patients

Epidemiological Burden of Lower Limb Spasticity in Adults: A Systematic Review

New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson’s disease

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