Prevalence of Restless Legs Syndrome Among Native South Americans Residing in Coastal and Mountainous Areas

Castillo, Pablo R.; Kaplan, Joseph; Lin, Siong-Chi; Fredrickson, Paul A.; Mahowald, Mark W.

doi:10.4065/81.10.1345

Cited by 53 publications

(33 citation statements)

References 19 publications

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“…5,8,15,16 A more recent study reported an RLS prevalence of 20.2% in Buenos Aires, Argentina, where the Hispanic population is predominantly of European descent. 28 The RLS prevalence we observed in HMD living in San Diego County is higher than the very low RLS prevalence reported for South American Native populations, 20 and lower than the RLS prevalence reported for homogeneous populations of European descent living in North and South America. 28,31 The majority of Mexicans are a mixture of Native American and European white ancestry which could account for the mid-range RLS prevalence we observed in the current study.…”

Section: Ethnic Differences In Rls Prevalencecontrasting

confidence: 45%

“…One study reported an RLS prevalence of 2% in native South Americans living in the costal and mountainous regions of Ecuador. Those living at higher altitude had a slightly higher RLS prevalence of 3.2%, 20 but well below the RLS prevalence of 5 to 15% reported for populations of European ancestry. 5,8,15,16 A more recent study reported an RLS prevalence of 20.2% in Buenos Aires, Argentina, where the Hispanic population is predominantly of European descent.…”

Section: Ethnic Differences In Rls Prevalencementioning

confidence: 92%

“…Since then, the RLS criteria have been translated into Spanish by others and validated in Hispanic populations. 20,21 The Spanish version of the ESS and the Short Acculturation Scale for Hispanics have been validated in Hispanic populations. 19,22,23 The Spanish version of the Sleep Heart Health Study Sleep Habits Questionnaire was used in 296 Hispanics.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Sawanyawisuth

Palinkas

Ancoli‐Israel

et al. 2013

Journal of Clinical Sleep Medicine

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Section: Ethnic Differences In Rls Prevalencecontrasting

confidence: 45%

Section: Ethnic Differences In Rls Prevalencementioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

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Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Sawanyawisuth

Palinkas

Ancoli‐Israel

et al. 2013

Journal of Clinical Sleep Medicine

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“…Epidemiologic studies have demonstrated a higher prevalence of RLS in patients residing in higher altitudes [59, 60]. RLS prevalence has been reported to be increased in patients with pulmonary disease, including chronic obstructive pulmonary disease (COPD) [61] and obstructive sleep apnea (OSA) [62].…”

Section: Introductionmentioning

confidence: 99%

Iron and restless legs syndrome: treatment, genetics and pathophysiology

Connor

Patton

Oexle³

et al. 2017

Sleep Medicine

101

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In this article, we review the original findings from MRI and autopsy studies that demonstrated brain iron status is insufficient in individuals with restless legs syndrome (RLS). The concept of deficient brain iron status is supported by proteomic studies from cerebrospinal fluid (CSF) and from the clinical findings where intervention with iron, either dietary or intravenous, can improve RLS symptoms. Therefore, we include a section on peripheral iron status and how peripheral status may influence both the RLS symptoms and treatment strategy. Given the impact of iron in RLS, we have evaluated genetic data to determine if genes are directly involved in iron regulatory pathways. The result was negative. In fact, even the HFE mutation C282Y could not be shown to have a protective effect. Lastly, a consistent finding in conditions of low iron is increased expression of proteins in the hypoxia pathway. Although there is lack of clinical data that RLS patients are hypoxic, there are intriguing observations that environmental hypoxic conditions worsen RLS symptoms; in this chapter we review very compelling data for activation of hypoxic pathways in the brain in RLS patients. In general, the data in RLS point to a pathophysiology that involves decreased acquisition of iron by cells in the brain. Whether the decreased ability is genetically driven, activation of pathways (eg, hypoxia) that are designed to limit cellular uptake is unknown at this time; however, the data strongly support a functional rather than structural defect in RLS, suggesting that an effective treatment is possible.

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“…Furthermore, sleep disorders are linked to poor mental and physical health and directly impact quality of life [4][5][6][7][8]. Prior studies have suggested ethnic differences in sleep-related disorders such as obstructive sleep apnea, restless legs syndrome, insomnia, and in sleep continuity and architecture [9][10][11][12][13][14][15][16][17][18][19]. The majority of sleep research has been conducted in Non-Hispanic Whites (NHW), and to a lesser extent in African-Americans and Asians.…”

Section: Introductionmentioning

confidence: 99%

Sleep Quality among Hispanics of Mexican Descent and Non-Hispanic Whites: Results from the Sleep Health and Knowledge in US Hispanics Study

Soler¹,

Díaz-Piedra²,

Bardwell³

et al. 2013

OJRD

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Objectives: To investigate differences in sleep quality between Hispanics of Mexican descent (HMD) and Non-Hispanic Whites (NHW) and evaluate the effect of acculturation to the US lifestyle in sleep health. We hypothesize that the detrimental effect of acculturation on health outcomes will impact sleep quality among HMD. Design: We performed a population-based random digit dialing telephone survey to determine sleep quality in HMD and NHW. We collected from 3667 subjects, demographics, previous diagnosis of depression or anxiety, past treatment for sleep disorders, the Pittsburgh Sleep Quality Index (PSQI) and the Short Acculturation Scale for Hispanics. Results: The prevalence of poor sleep quality (PSQI > 5) was 64.4% for HMD and 64.3% for NHW (p = 0.93). A prior diagnosis of depression or anxiety was an independent predictor of poor sleep quality in both groups (OR 3.4 and 2.7 for HMD and NHW. Ethnicity was not a predictor of poor sleep quality in HMD or NHW. Acculturation was not a predictor of poor sleep quality in HMD. However, highly acculturated young HMD males had significantly more prevalence of poor sleep quality compared to NHW (64.8% vs. 49.8%, p < 0.001). Conclusion: The absence of sleep quality differences in a large sample of HMD and NHW living in San Diego County is contrary to current data of having poorer sleep quality among Latinos. We found that neither ethnicity nor acculturation were predictors of poor sleep quality in HMD. However, we demonstrated a highly prevalent poor sleep quality among the two ethnic groups. The finding of significantly lower sleep quality in young highly acculturated HMD men may represent the heterogeneity of ethnicity related to sleep. Programs to improve sleep quality in subjects with depression and/or anxiety, and in young highly-acculturated HMD seems warranted.

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Prevalence of Restless Legs Syndrome Among Native South Americans Residing in Coastal and Mountainous Areas

Cited by 53 publications

References 19 publications

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Ethnic Differences in the Prevalence and Predictors of Restless Legs Syndrome between Hispanics of Mexican Descent and Non-Hispanic Whites in San Diego County: A Population-Based Study

Iron and restless legs syndrome: treatment, genetics and pathophysiology

Sleep Quality among Hispanics of Mexican Descent and Non-Hispanic Whites: Results from the Sleep Health and Knowledge in US Hispanics Study

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