Prevalence of Respiratory Syncytial Virus Infection among Hospitalized Children Presenting with Acute Lower Respiratory Tract Infections

Gupta, Soham; Shamsundar, Ranjani; Shet, Anita; Chawan, Rashmi; Srinivasa, H

doi:10.1007/s12098-011-0491-0

Cited by 27 publications

(16 citation statements)

References 9 publications

(16 reference statements)

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“…These findings were concordance with earlier reports from other states in India. The reported percentage positivity of RSV in Pune, Delhi, Haryana, Assam, Kolkata, and Bangalore was 18.6, 17.4, 23.4, 7.9, 10.3, and 21.1% respectively . The reported percentage positivity in other part of the world was 37% in Japan, 22.42% in Iran, 26% in Brazil, and 26.4% in Mexico .…”

Section: Discussionmentioning

confidence: 95%

“…Out of 22 sequences, 17 (77%) were clustered into newly designed NA1 genotype, and 5 (23%) sequences were clustered into novel ON1 genotype within NA1 genotype. ON1 genotype sequences showed 72 nucleotides (24 amino [22][23][24][25][26][27] The reported percentage positivity in other part of the world was 37% in Japan, 22.42% in Iran, 26% in Brazil, and 26.4% in Mexico. [28][29][30][31] The RSV has a definite seasonality; it occurs winter in temperate regions, monsoon season in tropical regions and autumn in semi-tropical areas.…”

Section: Phylogenetic Analysismentioning

confidence: 99%

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Genetic characterization respiratory syncytial virus in Kerala, the southern part of India

Patil

Balakrishnan

2017

Journal of Medical Virology

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Respiratory syncytial virus (RSV) is an important cause of acute lower respiratory tract infection (ALRI) in infants and young children globally. RSV presents two antigenic groups RSV-A and -B. Genetic variability is also very high within each group. RSV circulation varies year to year and even varies among different regions. Data on circulatory pattern of RSV are available from other parts of India except Kerala. The aim of the study was to generate data about groups and genotypes of circulating RSV in Kerala. In this study, RSV positive samples received during January, 2012 to December, 2014 were used for genetic characterization. The samples were tested by using nucleocapsid (N) gene-based conventional multiplex reverse transcriptase polymerase chain reaction (RT-PCR) to identify the RSV group. Genotyping was done by nucleotide sequencing of the C-terminal region of the glycoprotein (G) gene. Out of the 130 patient samples tested, 49 samples were positive for RSV. Among the positive samples, 32 belong to the RSV-A and 17 belong to RSV-B virus. Phylogenetic analysis revealed that all RSV-A sequences (n = 22) belonged to NA1 genotype and five of the sequences showed the novel 72 nucleotide duplication and clustered into the newly designated ON1 genotype. All RSV-B sequences (n = 17) were clustered into the BA (BA9 and 10) genotype. From this study, we concluded both RSV-A and -B were co-circulated in Kerala and RSV-A was observed predominantly in 2012 and RSV-B in 2014. As per our best of knowledge, BA10 genotype is first observed in India.

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Section: Discussionmentioning

confidence: 95%

Section: Phylogenetic Analysismentioning

confidence: 99%

Genetic characterization respiratory syncytial virus in Kerala, the southern part of India

Patil

Balakrishnan

2017

Journal of Medical Virology

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“…In a study performed by Boivin et al, [15] 46 % and 51 % RSV were detected by the real-time PCR method in 204 nasopharyngeal samples of children. Out of 77 samples tested for RSV with DFA, 17 (22.1 %) were found RSV-positive with a mean age of 8.24±7.21 mo in children by Gupta et al, [16]. Of the 126 patients, 46.66 % children were positive for RSV while 58.33 % were negative for RSV between the age of 4-24 mo by Hemalatha et al, [17].…”

Section: Discussionmentioning

confidence: 97%

Frequency of Common Viruses in Etiology of Acute Respiratory Tract Infections

et al. 2012

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“…Broor et al reported 30% bronchiolitis with causative agent as RSV. 7,8 We used amplification technique Reverse transcriptase RT-PCR. This was supported by Javed Akhtar etal.…”

Section: Incidence Of Rsv Brochiolitismentioning

confidence: 99%

Prevalence of raised IgE levels and absolute eosinophil count in bronchiolitis in children aged 2 months-2 years in tertiary care hospital

2016

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INTRODUCTIONBronchiolitis is defined by IAP as ' A constellation of clinical symptoms and signs including viral upper respiratory prodrome followed by increased respiratory effort and wheeze in less than 2 year old children'. Many virus cause bronchiolitis with Respiratory syncytial virus being common. Epidemiology of RSV has many unusual characteristics. They infect children nearly in first year of life with the peak incidence in 2-8 months. It is the only virus which cause most severe respiratory disease in the first month of life when there is antibodies from the mother.1 WHO estimated RSV burden globally as 64 million cases and 1,50,000 deaths every year. Peak incidences are at 2-8 months of age. This is one of the common causes of hospitalisation Intensive care is needed for about 15% to 30% of RSV infections. Due to respiratory failure, apnoea 7% to 21% of hospitalised patient needs mechanical ventilation.2 Some prospective study have suggested that RSV infection predisposes to blood eosinophilia and airway ABSTRACT Background: Bronchiolitis is defined by IAP as 'A constellation of clinical symptoms and signs including viral upper respiratory prodrome followed by increased respiratory effort and wheeze in less than 2 year old children'. Aim of the study was to study the prevalence of raised IgE levels and raised Absolute eosinophil count & RSV (respiratory syncytial virus) antigen by PCR in bronchiolitis between age group of 2 months -2 years with the occurrence of wheeze after first episode in 1 year follow up. Methods: 96 Children between 2 months -2 years with first episode of bronchiolitis are included with the exclusion criteria of previous heart disease, lung disease, immune deficiency, second episode of bronchiolitis. In all the children CRP (C reactive protein), IgE (Immunoglobulin E), AEC (Absolute eosinophil count), RSV, PCR was done. Results: Out of 96 children, 60 children (62%) are males with maximum incidence on subjects of 53 (55.2%) in age group 2-6months. Fever, cough and rhinorrhoea are the major presenting complaints apart from breathlessness. Among 96 children 37 children (38.5%) had high serum IgE out of which 17 developed wheeze in 1 year of follow up. 27 (28.2%) had raised AEC, out of which 10 had wheeze in follow up. Out of 10 children who had raised IgE and AEC, 3 had wheeze on follow up. 34 (35.4%) children had positive RSV PCR, 14 children had wheeze in follow up. Conclusions: The prevalence of raised IgE, AEC and RSV PCR are 38.5%, 28.1% and 41.1% and the occurrence of wheeze on follow up was 45.9%, 37% and 41.1% respectively.

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Prevalence of Respiratory Syncytial Virus Infection among Hospitalized Children Presenting with Acute Lower Respiratory Tract Infections

Abstract: RSV infection is a significant cause of morbidity among children presenting with ALRI in southern India. In resource-limited settings, DFA can be used as an important tool for rapid detection of RSV and can potentially eliminate prolonged hospitalization and unnecessary use of antibiotics.

Cited by 27 publications

References 9 publications

Genetic characterization respiratory syncytial virus in Kerala, the southern part of India

Genetic characterization respiratory syncytial virus in Kerala, the southern part of India

Frequency of Common Viruses in Etiology of Acute Respiratory Tract Infections

Prevalence of raised IgE levels and absolute eosinophil count in bronchiolitis in children aged 2 months-2 years in tertiary care hospital

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