Prevalence of Resistance to Antituberculosis Drugs in Riyadh and A Review of Previous Reports

Singla, Rupak; Al-Sharif, Nasser; Al-Sayegh, Mohammed; Osman, Mohammed; Shaikh, Mahmood

doi:10.5144/0256-4947.2003.143

Cited by 10 publications

(6 citation statements)

References 12 publications

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“…In our study, the rate of resistance of M tuberculosis to streptomycin was 6.9%. Similarly, in a study from Riyadh, streptomycin resistance was 8.8% 21 and 15.9% in Taif, 15 and 22.7% in Jeddah. 18 The resistance rates of M tuberculosis to streptomycin were 14.5% in Sierra Lion 11 and 6.6% in India.…”

Section: Discussionmentioning

confidence: 74%

Susceptibility Pattern and Epidemiology of Mycobacterium tuberculosis in a Saudi Arabian Hospital

Al‐Tawfiq

Al-Muraikhy

Abed

2005

Chest

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Section: Discussionmentioning

confidence: 74%

Susceptibility Pattern and Epidemiology of Mycobacterium tuberculosis in a Saudi Arabian Hospital

Al‐Tawfiq

Al-Muraikhy

Abed

2005

Chest

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“…The data revealed that 20.6% of patients in this study exhibited resistance to two drugs, 4.4% of patients exhibited resistance to 3 drugs, and 1.5% of patients exhibited resistance to 4 drugs. A previous report from Saudi Arabia [21] showed that 3.7% of all patients had resistance to at least three drugs, 3.6% of patients had resistance to at least two drugs, and 6.8% of patients had resistance to only one drug. TB that is resistant to two or more drugs is difficult to treat and often results in treatment failure.…”

Section: Discussionmentioning

confidence: 98%

Primary anti-tuberculous drugs resistance of pulmonary tuberculosis in Southwestern Saudi Arabia

Asaad¹,

Alqahtani²

2012

Journal of Infection and Public Health

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The emergence of drug-resistant tuberculosis (TB) is an increasing problem which adversely affects patient care and public health. This study aimed to determine the rates and patterns of primary anti-TB drugs resistance in Najran, Southwestern Saudi Arabia. The study included 80 smear-positive new pulmonary TB patients. Sputum samples were cultured on Lowenstein-Jensen and Middle-Brook 7H10 media. Mycobacterium tuberculosis susceptibility testing was done by the conventional agar proportion method for isoniazide (INH), rifampicin (RIF), streptomycin (SPM) and ethambutol (EMB). Out of the 68 M. tuberculosis isolates, 42 (61.8%) were sensitive to all 4 drugs and 26 (38.2%) were resistant to one or more drugs. The most common resistance was found to INH (33.8%), followed by RIF (23.5%), SPM (13.2%) and EMB (2.9%). Eight (11.8%) isolates were resistant to one drug, 14 (20.6%) were resistant to 2 drugs, 3 (4.4%) were resistant to 3 drugs and one (1.5%) was resistant to 4 drugs. Multi-drug resistant (MDR) isolates were found in 14 (20.6%) cases. In conclusion, the primary resistance rate to four first-line anti-tuberculous drugs and MDR-TB rate are worryingly high, representing an alarming situation in Najran. Further studies are necessary for continuous surveillance of M. tuberculosis resistance patterns.

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“…Streptomycin resistance in Saudi Arabia has been variable and reported figures are: 15.9% in Taif, 22.7% in Jeddah [7], 1-7% in Dammam area [8,18], and 8.8% in Riyadh [19].…”

Section: Discussionmentioning

confidence: 99%

“…The second most common resistance pattern noted in the study was streptomycin (10.4%). Streptomycin resistance in Saudi Arabia has been variable and reported figures are: 15.9% in Taif, 22.7% in Jeddah [ 7 ], 1–7% in Dammam area [ 8 , 18 ], and 8.8% in Riyadh [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010

Chaudhry¹,

Nagamani²,

Al-Shammri³

et al. 2011

JEGH

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Prevalence of Resistance to Antituberculosis Drugs in Riyadh and A Review of Previous Reports

Cited by 10 publications

References 12 publications

Susceptibility Pattern and Epidemiology of Mycobacterium tuberculosis in a Saudi Arabian Hospital

Susceptibility Pattern and Epidemiology of Mycobacterium tuberculosis in a Saudi Arabian Hospital

Primary anti-tuberculous drugs resistance of pulmonary tuberculosis in Southwestern Saudi Arabia

Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010

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