Prevalence of renal involvement in Indian patients with systemic sclerosis

Gupta, Ranjan; Bammigatti, Chanaveerappa; Dinda, AK; Marwaha, Vishal; Gupta, Sanjay

doi:10.4103/0019-5359.30349

Cited by 12 publications

(10 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gupta et al revealed that patients with <48 months disease duration had higher mean GFR (79.14±30.17 ml/min) compared to those >48 months (72±23.34 ml/min) [38], and this concurs with our findings. Also, in our study, there was a significantly higher percentage of SSc patients with reduced RFR (RFR<10%) among those with a disease duration of ≥48 months.…”

Section: Discussionsupporting

confidence: 93%

“…Also, in our study, there was a significantly higher percentage of SSc patients with reduced RFR (RFR<10%) among those with a disease duration of ≥48 months. Regarding various clinical and demographic data, no statistically significant correlations were found with any of the renal parameters, and this agrees with other previous studies [28,38]. However, a significant difference was found between the means of baseline GFR and RFR in SSc patients with and without pulmonary hypertension where all and 60% of SSc patients with pulmonary hypertension had abnormal RFR and reduced baseline GFR, respectively.…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Tc-99m diethylenetriamine pentaacetic acid (DTPA) renal function reserve estimation: is it a reliable predictive tool for assessment of preclinical renal involvement in scleroderma patients?

et al. 2012

View full text Add to dashboard Cite

Prognosis of systemic sclerosis (SSc) depends on internal organ involvement. We assessed the value of renal function reserve (RFR) for the detection of preclinical nephropathy in scleroderma. Thirty SSc patients with normal serum creatinine and 30 healthy controls were included. Medsger disease severity score, glomerular filtration rate (GFR), and microalbuminuria were measured. Tc-99m DTPA was utilized for GFR measurement at baseline and after oral protein overload (stimulated GFR). RFR was calculated as the percentile increase of stimulated GFR. SSc patients had lower means of baseline GFR (P=0.001), stimulated GFR (P=0.004), RFR (P=0.046), and higher microalbuminuria (P=0.009) than controls. According to baseline GFR, SSc patients showed three categories-normal baseline GFR (n=12), hyperfiltration GFR (n=3), and reduced baseline GFR (n=15). In the former category, RFR was normal in 6/12 patients and abnormal in the remainders (50%). Hyperfiltration patients and those with reduced baseline GFR showed abnormal RFR. A statistically significant negative association was found between microalbuminuria versus stimulated GFR and RFR (r= -0.5, P=0.007 and r= -0.45, P=0.013, respectively). The majority of SSc patients with abnormal RFR had disease duration of ≥48 months (60% vs. 20%, P=0.008). All SSc patients with pulmonary hypertension had abnormal RFR, while reduced baseline GFR was noted in only 60%. A significant negative correlation was found between reduced baseline GFR and cumulative dose of corticosteroids in SSc patients (r= -0.4, P=0.022). RFR estimation could be a useful predictive marker for preclinical renal involvement in SSc patients so that early prophylactic measures and therapy modifications could be considered.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Tc-99m diethylenetriamine pentaacetic acid (DTPA) renal function reserve estimation: is it a reliable predictive tool for assessment of preclinical renal involvement in scleroderma patients?

et al. 2012

View full text Add to dashboard Cite

show abstract

“…SRC occurs early in the course of disease (80% within the first 4 years) and is more common with the diffuse cutaneous variety, in subjects with ribonucleic acid polymerase III antibodies and treatment with high‐dose steroids . Racial and genetic predisposition has also been observed with the disease being more common in Caucasians than in Asians . Absence of hypertension has been noted in about 10% of patients.…”

Section: Renal Involvement As a Direct Results Of Rheumatological Diseasementioning

confidence: 99%

Rheumatological diseases and kidneys: a nephrologist's perspective

Mittal

Rathi

2014

Int J Rheum Dis

View full text Add to dashboard Cite

Renal involvement is a common occurrence in subjects with rheumatological diseases and can develop either due to the disease itself or secondary to drugs used in the treatment. The prevalence of renal involvement and its severity depends on the underlying disease as well as aggressiveness of the therapy. For most rheumatological diseases, renal involvement heralds a poor prognosis and warrants aggressive immunosuppressive treatment. Thus, it is important to diagnose and manage them at an early stage. On the other hand, patients with primary kidney disease can also develop rheumatological manifestations which need to be differentiated from the former. This article provides the nephrologist's perspective upon various rheumatological disorders and associated renal involvement with the aim of sensitizing the rheumatological community about them, resulting in better management of these subjects.

show abstract

“…Data regarding prevalence, risk factors and outcomes in SRC in Asian populations are limited. This study was performed to determine the prevalence, risk factors and outcomes of SRC in Thai patients with SSc, of which the majority were of the dcSSc subset.…”

Section: Introductionmentioning

confidence: 99%

“…10 Previously proposed risk factors for SRC reported from Western countries include diffuse skin involvement, 11 rapid progression of skin involvement, 12 disease duration < 4 years since scleroderma onset, 11 new cardiac event (pericardial effusion, congestive heart failure), 12 anemia, 12 presence of anti-RNA-polymerase III antibodies, 13 prednisolone dose ≥ 15 mg/day 14 and cyclosporine therapy. 15 Data regarding prevalence, 16,17 risk factors and outcomes in SRC in Asian populations are limited. This study was performed to determine the prevalence, risk factors and outcomes of SRC in Thai patients with SSc, of which the majority were of the dcSSc subset.…”

Section: Introductionmentioning

confidence: 99%