Prevalence of Renal Cell Carcinoma in Patients With Autosomal Dominant Polycystic Kidney Disease and Chronic Renal Failure

Hajj, Pascal; Ferlicot, Sophie; Massoud, W.; Awad, Ayman; Hammoudi, Y.; Charpentier, B; Dürrbach, Antoine; Droupy, S.; Galand, Benoît

doi:10.1016/j.urology.2009.02.078

Cited by 106 publications

(108 citation statements)

References 20 publications

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“…Therefore, they concluded that ADPKD was a risk factor for RCC among kidney transplant recipients and screening such as ultrasound should be performed for RCC in such patients (8), which consistent with study of Hajj et al (12). They reported a high prevalence of RCC in patients with end stage kidney disease as well as patients undergoing kidney transplantation (12).…”

Section: Implication For Health Policy/practice/research/medical Educsupporting

confidence: 64%

Are acquired cystic kidney disease and autosomal dominant polycystic kidney disease risk factors for renal cell carcinoma in kidney transplant patients?

Einollahi¹

2012

J Nephropathol

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Section: Implication For Health Policy/practice/research/medical Educsupporting

confidence: 64%

Are acquired cystic kidney disease and autosomal dominant polycystic kidney disease risk factors for renal cell carcinoma in kidney transplant patients?

Einollahi¹

2012

J Nephropathol

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“…[9][10][11] Additionally, native nephrectomy may be undertaken in the presence of suspected malignancy; RCC is 2 to 3 times more likely in the ADPKD-ESRD population than in the ESRD population without ADPKD. 12 Although the indications for native nephrectomy may be related to kidney size, the decision to proceed with native nephrectomy is often undertaken on an individual basis, without specific reference to kidney size measurements.…”

Section: Introductionmentioning

confidence: 99%

Maximal kidney length predicts need for native nephrectomy in ADPCKD patients undergoing renal transplantation

Cristea¹,

Yanko²,

Felbel³

et al. 2014

CUAJ

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Introduction: Native nephrectomy in patients with autosomal dominant polycystic kidney disease (ADPKD) is performed on a case-by-case basis. We determine if pre-transplant maximal kidney length (MKL) can be used to predict ultimate nephrectomy status. Methods: We performed a retrospective review of ADPKD patients who underwent renal transplantation at our centre between January 2000 and December 2012. Pre-transplant measurements of MKL alone, MKL adjusted for height (HtMKL), weight (WtMKL) and body mass index (BMI-MKL) were each assessed for their predictive ability via a receiver operating characteristic (ROC) curve analysis. Results: In total, 84 patients met our inclusion criteria, of which 17 (20.2%) underwent native nephrectomy. An MKL ROC curve analysis revealed an area under the curve (AUC) of 0.867 (95% confidence interval [CI] 0.775-0.931; p < 0.001). An optimal cutoff criterion of >21.5 cm revealed a sensitivity of 94.1% (95% CI 71.3-99.9) and specificity of 70.1% (95% CI 57.7-80.7) for eventual nephrectomy. The AUC of HtMKL, WtMKL and BMI-MKL ROC curves did not differ significantly from MKL alone. HtMKL improved specificity, but not overall test performance. The determination of the cut-off MKL may be influenced by the single-centre retrospective nature of this analysis, as well as the fact that renal size was determined by ultrasound and not computerized tomography or magnetic resonance imaging. Conclusion: MKL in patients with ADPKD is associated with the eventual need for nephrectomy and may be a useful clinical tool to risk stratify these patients and therefore guide patient conversations to a decision to leave the native kidneys in situ.

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“…Most cases of RCC in ADPKD have been unilateral, however, 12 cases of bilateral RCC in this patient population have been reported since the first in 1954 by Borski and Kimbrough [2,3]. While premalignant changes have been shown to occur in ADPKD, clinical research has not supported an association between RCC and ADPKD until Hajj et al suggested an increased incidence of RCC in patients with ADPKD [4][5][6]. Current literature recognizes that RCC tends to occur at a younger age, and is more often bilateral in ADPKD patients, however, there is currently no recognized increased risk of RCC amongst ADPKD patients compared to the general population [7,8].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Association of Autosomal Dominant Polycystic Kidney Disease and renal cell Carcinoma

Lane¹,

Lacefield²,

Tran³

et al. 2011

OJU

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Autosomal Dominant Polycystic Kidney Disease (ADPKD) is not currently considered to be a risk factor for renal cell carcinoma (RCC). We present data from our institution demonstrating incidence of RCC with ADPKD above the incidence rate for RCC in the general population, as well as that in patients with end-stage renal disease (ESRD). The discussion relates our findings in the context of the current literature including recent case reports published in this entity.

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Prevalence of Renal Cell Carcinoma in Patients With Autosomal Dominant Polycystic Kidney Disease and Chronic Renal Failure

Cited by 106 publications

References 20 publications

Are acquired cystic kidney disease and autosomal dominant polycystic kidney disease risk factors for renal cell carcinoma in kidney transplant patients?

Are acquired cystic kidney disease and autosomal dominant polycystic kidney disease risk factors for renal cell carcinoma in kidney transplant patients?

Maximal kidney length predicts need for native nephrectomy in ADPCKD patients undergoing renal transplantation

The Clinical Association of Autosomal Dominant Polycystic Kidney Disease and renal cell Carcinoma

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