Prevalence of reduced carbon monoxide transfer factor in smokers with normal spirometry

Cheung, T. H. C.; Papanikolaou, Vicki; Finlay, Paul N.; Yong, Theresa; MacDonald, Martin; Thompson, Bruce; Bardin, Philip G.; King, Paul T.

doi:10.1016/j.rmed.2021.106422

Cited by 1 publication

(1 citation statement)

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“…The population prevalence of DLCO below the LLN identified in our study in current and former smokers (19.8%) is consistent with the 17% previously described in active smokers selected from advertisements to assess lung health10 and 24% identified in a retrospective analysis of a lung function database 33. In addition, our data confirm the relationship of DLCO with some previously identified variables, such as male gender or spirometric parameters 34–36.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study

et al. 2023

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BackgroundPopulation distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.MethodsA sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. Baseline evaluation included clinical questionnaires, exhaled carbon monoxide (CO) measurement, spirometry, DLCO determination, 6 min walk test, routine blood analysis and low-dose CT scan with evaluation of lung density and airway wall thickness.ResultsIn never, former and current smokers, prevalence of reduced DLCO was 6.7%, 14.4% and 26.7%, respectively. Current and former smokers with reduced DLCO without airflow limitation were younger than the subjects with normal DLCO, and they had greater levels of dyspnoea and exhaled CO, greater pulmonary artery diameter and lower spirometric parameters, 6 min walk distance, daily physical activity and plasma albumin levels (all p<0.05), with no significant differences in other chronic respiratory symptoms or CT findings. FVC and exhaled CO were identified as independent risk factors for low DLCO.ConclusionReduced DLCO is a frequent disorder among smokers without airflow limitation, associated with decreased exercise capacity and with CT findings suggesting that it may be a marker of smoking-induced early vascular damage.Trial registration numberNCT03028207.

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Section: Discussionsupporting

confidence: 91%