Prevalence of recurrent aphthous stomatitis in western population of Maharashtra, India

Rajmane, Yojari R; Ashwinirani, SR; Suragimath, Girish; Nayak, Akshatha; Rajmane, Vijaya; Lohana, Mohini

doi:10.4103/jorr.jorr_33_16

Cited by 14 publications

(8 citation statements)

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“…In the current study, the number of females was higher than males, which is similar to other studies that suggest that females are at a higher risk of RAS development than males [ 21 , 22 ]. In addition, females had more ATDs than males due to higher rates of anti-TPO positivity in women [ 23 ].…”

Section: Discussionsupporting

confidence: 91%

Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis

Karimi,

Lavaee,

Nematollahi

et al. 2023

BMC Oral Health

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Background Recent investigations have highlighted autoimmune origins and abnormal immune responses; particularly those related to T cell-mediated immunity and elevated T lymphocyte cells in the oral mucosa. Therefore, we investigated the relationship between recurrent aphthous stomatitis (RAS) and autoimmune thyroid diseases (ATDs) in an Iranian population. Methods A cross-sectional study was performed on 102 patients diagnosed with ATD (cases) and 102 healthy patients (controls) who had been referred for the routine dental treatment. All participants were asked for the history of RAS and their age, gender, other systemic diseases, medications, and frequency of RAS in a year. Matching was performed based on the propensity scores for age and sex. In addition, the number of lesions in each recurrence in both groups was assessed and compared. The type of thyroid disease has been assessed for case participants and has been confirmed by the endocrinologist. The chi-square test, t-test, and Mann-Whitney U test were used to analyze the data using SPSS 18. Results Patients with ATD had higher RAS than healthy controls (P = 0.040). ATD patients had 1.93 times more risk for RAS, and the frequency of RAS in a year was 3.15times higher in these patients (P = 0.011). Moreover, the frequency of RAS was higher in patients with hypothyroidism than in those with hyperthyroidism. However, there were no significant differences in the size and the number of lesions between the groups. Conclusion The risk and frequency of RAS were significantly higher in patients with ATDs. This would provide valuable insights into the underlying mechanisms and potential treatment strategies for both conditions.

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Section: Discussionsupporting

confidence: 91%

Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis

Karimi,

Lavaee,

Nematollahi

et al. 2023

BMC Oral Health

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show abstract

“…In the current study, the number of females was higher than males, which is similar to other studies that seem to suggest females are at a higher risk of RAS development in comparison to males (21,22). Also, females had more ATDs than males due to higher rates of anti-TPO positivity in women (23).…”

Section: Discussionsupporting

confidence: 89%

Assessing the Thyroid Autoimmunity Association with Recurrent Aphtous Stomatitis

Karimi

Lavaee

Nematollahi

et al. 2023

Preprint

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Background Recurrent aphthous stomatitis (RAS), a common disease of the oral mucosa, can be painful and reduce the quality of life. Since many investigations have focused on the autoimmune origins of RAS, we aimed to investigate the relationship between RAS and autoimmune thyroid diseases (ATDs) in an Iranian population. Methods A cross-sectional study was done on 102 patients diagnosed with ATD (case) and 102 healthy patients (control) who had been referred for their routine dental treatments. All participants were asked for the history of RAS and their age, gender, other systemic diseases, medications, and frequency of RAS in a year. Matching was done based on propensity score for age and gender. Also, the number of lesions in each recurrence in both groups has been assessed and compared. The type of thyroid disease has been assessed for case participants and has been confirmed by the endocrinologist. The chi-square test, T-test, and Man-Whitney test were used to analyze the data by SPSS 18. Results The patients with ATD had more RAS in comparison to healthy controls (P = 0.040). ATD patients had 1.93times more risk for RAS, and the frequency of RAS in a year was 3.15times higher in these patients (P = 0.011). Moreover, the frequency of RAS was higher in patients with hypothyroidism than in patients with hyperthyroidism (P = 0.03). However, there were no significant differences regarding the size and the number of lesions between the groups. Conclusion The risk and frequency of RAS was significantly higher in patients with ATDs. However, the size and the number of lesions had no relationship to ATD.

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“…This study was in accordance with the finding of Rajmane et al, which showed that the most commonly affected age group with recurrent aphthous stomatitis was 20 to 29 years (56.9%), and the prevalence decreased with age. 12 Kaur et al assessed the prevalence of recurrent aphthous stomatitis in the North Indian population; the study showed that 60% of the patients with recurrent aphthous stomatitis were in the age group of 20 to 30 years. 13 Studies showed that 80% of recurrent aphthous stomatitis patients experienced this disorder for the first time before the age of 30 years; the peak is in their 20s.…”

Section: Discussionmentioning

confidence: 99%

“…A score of 0 to 13 indicated mild stress, a score of 14 to 26 indicated moderate stress, and a score of 27 to 40 indicated severe stress. 11,12 After that, blood samples of all the patients were taken. A blood (serum) sample was obtained early morning (7-9 a. m.).…”

Section: Methodsmentioning

confidence: 99%

The Role of Stress in Recurrent Aphthous Stomatitis

Nurdiana

Ritonga

Wulandari

2023

European Journal of General Dentistry

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Objectives This study aimed to determine the role of stress in recurrent aphthous stomatitis. Stress was examined with the Perceived Stress Scale and cortisol levels; meanwhile, recurrent aphthous stomatitis was assessed with the duration of the lesion. Materials and Methods This was a cross-sectional analytical study conducted at Oral Medicine Installation, Universitas Sumatera Utara Dental Hospital, and Prodia Laboratory, Medan. The subjects were 50 patients with minor recurrent aphthous stomatitis, without systemic disease, who did not take systemic drugs or use orthodontic appliances. The diagnosis of recurrent aphthous stomatitis was established with anamnesis and clinical examination. Stress was examined by filling out the Perceived Stress Scale questionnaire and blood tests for serum cortisol levels. Statistical analysis The data were analyzed using the Fisher test and Mann–Whitney U test. Results This study showed no significant relationship between the Perceived Stress Scale category and recurrent aphthous stomatitis, with a p-value of 0.392. This study also showed no significant relationship between blood cortisol level and recurrent aphthous stomatitis with a p-value of 1.000. Conclusion Stress may play an important role in recurrent aphthous stomatitis. However, this study did not show any difference in stress examined through the Perceived Stress Scale and cortisol levels based on the duration of recurrent aphthous stomatitis.

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Prevalence of recurrent aphthous stomatitis in western population of Maharashtra, India

Cited by 14 publications

References 0 publications

Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis

Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis

Assessing the Thyroid Autoimmunity Association with Recurrent Aphtous Stomatitis

The Role of Stress in Recurrent Aphthous Stomatitis

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