Prevalence of rectal and pharyngeal infection in women with gonorrhoea in Sheffield.

Kinghorn, G R; Rashid, Sakina Mehboob

doi:10.1136/sti.55.6.408

Cited by 22 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 The prevalence of concurrent rectal gonorrhea increases with the duration of cervical infection, because time increases the chance of perineal contamination. 19 Thus, one explanation may be that adolescent women seen in an STD clinic have less access to health care and a longer duration of cervical gonorrhea infections, leading to a higher prevalence of rectal infections from perineal contamination rather than from anal sex.…”

Section: Discussionmentioning

confidence: 99%

Culture of Non-Genital Sites Increases the Detection of Gonorrhea in Women

Giannini

Kim

Mortensen

et al. 2010

Journal of Pediatric and Adolescent Gynecology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Culture of Non-Genital Sites Increases the Detection of Gonorrhea in Women

Giannini

Kim

Mortensen

et al. 2010

Journal of Pediatric and Adolescent Gynecology

View full text Add to dashboard Cite

“…Our results along with published studies suggest that if vaginal screening alone is used, missed infection ranges from 18–40% for GC 5,16,17,22 and 6–25% for CT. 4,5,16,17,19 Although there was past debate about whether the rectum was truly infected in women having STIs, 23 recent reports document that the rectum can serve as a reservoir. 24,25 Gratix, et al 18 reported that when CT testing was expanded to include evaluation of rectal swabs, case detection for CT increased by 44%, leading them to support universal screening of women attending STI clinics.…”

Section: Discussionmentioning

confidence: 99%

Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse

Danby¹,

Cosentino²,

Rabe³

et al. 2016

Sexually Transmitted Diseases

View full text Add to dashboard Cite

Background Screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) in men who have sex with men (MSM) is risk-based. Despite high frequencies of oral and receptive anal intercourse (RAI) among women, extragenital screening is not recommended. Methods Women (n=175) and MSM (n=224) primarily recruited from a sexually transmitted infections clinic reporting a lifetime history of RAI completed a structured questionnaire and clinician collected swab samples from the rectum, pharynx, vagina (women) and urine (men). CT and GC were detected using two commercial nucleic acid amplified tests (Aptima Combo 2, Hologic, Inc., Bedford, MA; Xpert CT/NG, Cepheid Innovation, Sunnyvale, CA). Results The median age of the population was 26 years, 62% were Caucasian, and 88% were enrolled from a Sexually Transmitted Diseases clinic. Men were more likely than women to have GC (22.8% vs. 3.4%) and CT (21.9% vs. 12.6%). In men vs. women, GC was detected in 16.5% vs. 2.3% of pharyngeal swabs, 11.6% vs. 2.3% of rectal swabs and 5.4% vs. 2.9% of urine samples or vaginal swabs. CT was detected in 2.2% vs. 1.7% of pharyngeal swabs, 17.4% vs. 11.4% of rectal swabs, and 4.5% vs 10.3% for urogenital sites in men vs. women. Overall 79.6% of CT and 76.5% of GC in men and 18.2% of CT and 16.7% of GC in women were detected only in the pharynx or rectum. Conclusion Reliance on urogenital screening alone misses the majority of GC and CT in men and more than 15% of infections in women reporting RAI.

show abstract

“…Second, there is the possibility that false positive rectal GC/CT results may be due to cross contamination with urogenital secretions during sample collection, especially for samples tested by NAAT and if rectal samples are obtained without the use of a proctoscope. 6,10,16,[29][30][31] The risk of cross contamination is a challenge for all studies that characterize rectal GC/CT infection in women. Nevertheless, in our study, 14% of women with rectal GC did not have urogenital GC and 14% of women with rectal CT did not have urogenital CT. We believe that cross contamination cannot be wholly responsible for the high prevalence of rectal infections identified in this study.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Rectal Gonorrhea and Chlamydia Infection in Women Attending a Sexually Transmitted Disease Clinic

Bazan

Reese

Esber

et al. 2015

Journal of Women's Health

View full text Add to dashboard Cite

Background: Testing women for urogenital Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) is common in sexually transmitted disease (STD) clinics. However, women may not be routinely tested for rectal GC/CT. This may lead to missed infections in women reporting anal intercourse (AI). Methods: This was a retrospective review of all women who underwent rectal GC/CT testing from August 2012 to June 2013 at an STD clinic in Columbus, Ohio. All women who reported AI in the last year had a rectal swab collected for GC/CT nucleic acid amplification testing (n = 331). Using log-binomial regression models, we computed unadjusted and adjusted associations for demographic and behavioral factors associated with rectal GC/CT infection. Results: Participants (n = 331) were 47% African-American, with median age of 29 years. Prevalence of rectal GC was 6%, rectal CT was 13%, and either rectal infection was 19%. Prevalence of urogenital GC and CT was 7% and 13% respectively. Among women with rectal GC, 14% tested negative for urogenital GC. Similarly, 14% of women with rectal CT tested negative for urogenital CT. In unadjusted analyses, there was increased rectal GC prevalence among women reporting sex in the last year with an injection drug user, with a person exchanging sex for drugs or money, with anonymous partners, and while intoxicated/high on alcohol or illicit drugs. After multivariable adjustment, no significant associations persisted, but a trend of increased rectal GC prevalence was observed for women < 26 years of age ( p = 0.06) and those reporting sex while intoxicated/high on alcohol or drugs ( p = 0.05). For rectal CT, only age < 26 years was associated with prevalent infection in unadjusted models; this association strengthened after multivariable adjustment (prevalence ratio: 6.03; 95% confidence interval: 2.29-15.90). Conclusion: Nearly one in five women who reported AI in the last year had rectal GC or CT infection. Urogenital testing alone would have missed 14% of rectal infections. Standardized guidelines would increase rectal GC/CT testing in women and help detect missed infections.

show abstract

Prevalence of rectal and pharyngeal infection in women with gonorrhoea in Sheffield.

Cited by 22 publications

References 11 publications

Culture of Non-Genital Sites Increases the Detection of Gonorrhea in Women

Culture of Non-Genital Sites Increases the Detection of Gonorrhea in Women

Patterns of Extragenital Chlamydia and Gonorrhea in Women and Men Who Have Sex With Men Reporting a History of Receptive Anal Intercourse

High Prevalence of Rectal Gonorrhea and Chlamydia Infection in Women Attending a Sexually Transmitted Disease Clinic

Contact Info

Product

Resources

About