Prevalence of Raised Intracranial Pressure in Cerebral Malaria Detected by Optic Nerve Sheath Ultrasound

Beare, Nicholas A. V.; Glover, Simon J.; Lewallen, Susan; Taylor, Terrie E.; Harding, Simon; Molyneux, Malcolm E.

doi:10.4269/ajtmh.2012.11-0459

Cited by 21 publications

(21 citation statements)

References 19 publications

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“…Newton et al had also reported in 1997 that children with a severe raised ICP had more frequent sequelae [21]. In 2012, while concluding their research work conducted on CM, Beare et al also reported a significantly raised ONSD identified in children discharged with sequelae compared to children who recovered [5].…”

Section: Onsd and Outcomementioning

confidence: 96%

“…In [34]. Furthermore, papilledema is more common among children with raised ONSD [5]. Papilledema may be associated with the following signs of malaria retinopathy: retinal pallor, vascular changes and retinal hemorrhages.…”

Section: Onsd and Agementioning

confidence: 99%

“…The pathophysiology of CM is still poorly clarified. However, several studies demonstrated the presence and the role of raised intracranial pressure (ICP) in the occurrence of deaths and neurological sequelae [3] [4] [5] [6] [7]. The reference method for the diagnosis (gold standard) of raised ICP is continuous measurement of ICP with intraventricular catheter or intraparenchymal sensor.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, this exam, which is affordable, accessible and available in developing countries, allows non-invasive reassessments of ICP. This technique was used in many research works to evidence the raised of ICP during CM, especially in the child [5] [14] [18]. Can the optic nerve sheath diameter measured using ultrasonography be a prognostic tool for children suffering from CM and thus contribute to providing their better care?…”

Section: Introductionmentioning

confidence: 99%

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Sonographic Measurement of Optic Nerve Sheath Diameter: A Prognostic Tool for Childhood Cerebral Malaria?

Tové¹,

Tové-Sissinto²,

Adedemy³

et al. 2019

OJRad

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Background: Childhood cerebral malaria is one of the most frequent complications of malaria, with high morbidity and mortality. Raised Intracranial Pressure (ICP) is currently recognized as a fundamental element of the severity of that disease. This study aims to look into the prognostic role of the sonographic measurement of optic nerve sheath diameter (ONSD) in the context of that disease. Methods: This study was conducted in the pediatric and imaging departments of the University Hospital Center of Parakou in Republic of Benin in West Africa. This was a descriptive cross-sectional study with a prospective data collection conducted over a period of 6 months, from March 1st to August 31st, 2014. There were two groups of children with severe malaria and conscious impairment: one with unrousable coma or Cerebral Malaria (Group 1) and the other without unrousable coma (Group 2), benefitting from ONSD sonographic measurement. ONSD was measured 3 mm behind the papilla. Correlation between depth of coma, outcome and ONSD measure on ultrasound was investigated. Results: Group 1 consisted of 37 children and Group 2 of 50 children, i.e. a sample of 87 children. The mean age was 27.21 ± 20.11 months and sex ratio (Male/Female) estimated at 0.89. The average ONSD of the sample was 4.39 ± 0.94 mm with a significant difference (p = 0.0001) between Group 1 (5.09 ± 1.09 mm) and Group 2 (3.87 ± 0.17 mm). Raised ICP prevalence was 48.28% with a significant difference between Group 1 (83.78%) and Group 2 (22%) with p < 0.0001. ONSD was higher in children with unfavorable clinical outcome than in those cured (p = 0.0012

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Section: Onsd and Outcomementioning

confidence: 96%

Section: Onsd and Agementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sonographic Measurement of Optic Nerve Sheath Diameter: A Prognostic Tool for Childhood Cerebral Malaria?

Tové¹,

Tové-Sissinto²,

Adedemy³

et al. 2019

OJRad

View full text Add to dashboard Cite

show abstract

“…Lung function (26) POCUS can be used to differentiate between different emergent pulmonary conditions including COPD exacerbations, pneumonia, pulmonary embolism and pulmonary edema. Elevated intracranial pressure (27)(28)(29) Ocular ultrasonography to measure ocular nerve sheath diameter can be used to detect elevated intracranial pressures including in pediatric cerebral malaria and those with hypertensive urgency or emergency. Leprosy (30) Ultrasonography can be used to monitor response to treatment in some types of leprosy.…”

Section: How Did We Get Here? Non-maleficence and Justice Meet Pragmamentioning

confidence: 99%

Ultrasound in rural India: a failure of the best intentions

Phutke¹,

Laux²,

Jain

et al. 2019

IJME

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The Pre-Conception and Pre-Natal Diagnostic Techniques Act was written to prevent societally unacceptable harms including intentional sex selection. The pragmatism required to enforce this law has profound effects on the ability of rural Indians to access diagnostic ultrasonography. In so doing, it may have inadvertently placed a heavier burden on the poorest and worsened health inequity in India, creating serious ethical and justice concerns. It is time to re-examine and update the law such that diagnostic ultrasonography is widely available in even the most peripheral primary health and community health centres. Shorter, more accessible ultrasonography training courses should be offered; collaboration between radiologists and rural practitioners and facilities should be encouraged. Finally, modern ultrasound machines can carefully record all images via a "silent observer" modality. With some modifications to previously used silent observer modalities, this technology allows both greater access and better policing of potential misuse of ultrasound technology.

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Bedside ocular ultrasonography for diagnosing increased intracranial pressure in patients with leptomeningeal metastases from non‐small‐cell lung cancer

Jiang

Lin

et al. 2022

Cancer Medicine

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Objectives To explore the diagnostic accuracy of ultrasound measurement of optic nerve sheath diameter (ONSD) and optic disc height (ODH) in detecting intracranial hypertension in non‐small‐cell lung cancer (NSCLC) patients with leptomeningeal metastases (LM). Methods Seventy‐two patients with NSCLC‐LM and 65 patients with NSCLC were enrolled. The ONSD, ODH, eyeball transverse diameter (ETD), and eyeball vertical diameter (EVD) were measured by ultrasound. Subsequently, lumbar puncture was performed in NSCLC‐LM patients to measure cerebrospinal fluid pressure (CSFP), and intrathecal chemotherapy was regularly implemented. Pearson's correlation analysis was used to analyze the relationship between CSFP and ultrasound findings. The diagnostic accuracy of ONSD, ODH, and combined ONSD and ODH was evaluated by receiver operating characteristic (ROC) curve analysis and the corresponding area under the ROC curve (AUC). Results The ONSD, ODH, ONSD/ETD, and ONSD/EVD values were higher in the NSCLC‐LM group (all p < 0.05). The ONSD, ODH, ONSD/ETD, and ONSD/EVD values were all elevated in the abnormally elevated CSFP group (all p < 0.05). ONSD, ODH, ONSD/ETD, and ONSD/EVD were positively correlated with CSFP ( r = 0.531, 0.383, 0.534, and 0.535, all p < 0.0001). The AUCs for ONSD, ODH, ONSD/ETD, and ONSD/EVD to detect CSFP >280 mmH2O were 0.787 (95% CI: 0.64–0.93, sensitivity 68.75%, specificity 91.07%), 0.885 (95% CI: 0.81–0.96, sensitivity 100%, specificity 69.64%), 0.765 (95% CI: 0.64–0.89, sensitivity 81.25%, specificity 64.29%), and 0.788 (95% CI: 0.64–0.93, sensitivity 56.25%, specificity 91.07%), respectively. When ONSD was combined with ODH, the AUC was 0.913 (95% CI: 0.83–0.99, sensitivity 87.85%, specificity 85.70%). Furthermore, intrathecal chemotherapy was associated with a downtrend in CSFP and ultrasound findings. Conclusion There are important advantages of using bedside ultrasonography for detecting elevated CSFP in NSCLC‐LM patients. Further research should be performed to evaluate the clinical significance of an enlarged ONSD and increased ODH in NSCLC‐LM.

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Prevalence of Raised Intracranial Pressure in Cerebral Malaria Detected by Optic Nerve Sheath Ultrasound

Cited by 21 publications

References 19 publications

Sonographic Measurement of Optic Nerve Sheath Diameter: A Prognostic Tool for Childhood Cerebral Malaria?

Sonographic Measurement of Optic Nerve Sheath Diameter: A Prognostic Tool for Childhood Cerebral Malaria?

Ultrasound in rural India: a failure of the best intentions

Bedside ocular ultrasonography for diagnosing increased intracranial pressure in patients with leptomeningeal metastases from non‐small‐cell lung cancer

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