Prevalence of raised body mass index in paediatric sickle cell disease

Abstract

Aim Children with sickle cell disease (SCD) have historically weighed less than their healthy peers. More recently, a retrospective chart review from six institutions in New England reported nearly one‐quarter of children and adolescents with SCD had raised body mass index (BMI). This study aimed to examine rates of children with SCD with raised BMI in Mississippi compared to state and national norms and assess the correlation between haemoglobin and BMI. Methods A retrospective chart review of paediatric patients with SCD at the University of Mississippi Medical Center (UMMC) was conducted using data from the most recent clinic visit. Mississippi and national weight status estimates for youth 10–17 years were obtained from the 2016–2017 National Survey of Children's Health. Results For youth 10–17 years with SCD (n = 345), 21.4.% of children with SS/Sβ° and 36.1% with SC/Sβ+ had raised BMI compared to Mississippi and national rates, 39.2 and 31%, respectively. The prevalence of children with raised BMI with SC/Sβ+ did not differ from state and national rates, while children with SS/Sβ° were half as likely as their Mississippi peers to have raised BMI. Haemoglobin levels were different among children with SCD who had low BMI (8.80 g/dL), average BMI (9.2 g/dL) and raised BMI (10.5 g/dL) (P < 0.001). Conclusions Children with SCD evaluated at UMMC have similar rates of raised BMI compared to state and national norms. Children with raised BMI have higher mean haemoglobin levels compared to children with SCD with low or average BMI. Implications and Contribution Historically, patients with SCD have been underweight and normal weight. Our paediatric and adolescent patients with SCD now have prevalence rates of raised BMI that approach state and national rates. Further work must be done to determine whether this reflects healthier children with SCD or raises concerns about life‐style‐related comorbidities.

Sickle Cell Disease in Jhabua and Khargone District: Unveiling Prevalence and Severity

“…Body mass index (BMI) showed that 62% of the patients were underweight, while the remaining patients had a normal BMI. Contrasting results were found in the study conducted by Jackson et al, which revealed raised BMI [10].…”

Body Mass Index and Associated Medical Expenditures in the US Among Privately Insured Individuals Aged 2 to 19 Years in 2018

“…Confounding conditions included congenital malformations, brain injury, seizure, technology dependence, cancer, eosinophilic esophagitis or milk protein intolerance, malabsorption syndrome or lactose intolerance, and hypothyroidism or growth hormone deficiency, and other conditions that grouped together conditions with fewer than 100 individuals into 1 category (eTable 2 in Supplement 1). Fisher exact test showed pairwise correlation coefficients to be less than 0.7 for all conditions; hence, no further action was required to account for multicollinearity (eTable 3 in Supplement 1). We performed sensitivity analysis by adjusting for 2 additional conditions—eating disorders and psychiatric conditions—along with 9 conditions used in the fully adjusted model and presented the results of Fisher exact test (eTable 4 in Supplement 1) and marginal cost estimates (eTable 5 in Supplement 1).…”

“…in Supplement 1). [32][33][34][35][36][37][38][39][40][41][42][43][44] Fisher exact test showed pairwise correlation coefficients to be less than 0.7 for all conditions; hence, no further action was required to account for multicollinearity (eTable 3 in Supplement 1). We performed sensitivity analysis by adjusting for 2 additional conditions-eating disorders and psychiatric conditions-along with 9 conditions used in the fully adjusted model and presented the results of Fisher exact test (eTable 4 in Supplement 1) and marginal cost estimates (eTable 5 in Supplement 1).…”