Prevalence of primary open-angle glaucoma in a Somalia population

Kalaycı, Mustafa; Çetinkaya, Ersan; Erol, Muhammet Kazım

doi:10.1007/s10792-020-01612-0

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…These studies included a limited number of provinces and/or samples, whereas our research used data collected from a nationwide survey, which applied the PPS to randomly chosen respondents in 28 provinces, and got nationally representative samples. However, the global prevalence of glaucoma in the population aged 40–80 years is 3.54%, and it is 7% in Africa, which is much higher than the rate in China, reported in both our study and other studies 1,17. In addition, although our data showed that there was no difference between the prevalence of glaucoma in urban and rural areas, other studies have indicated that POAG is more prevalent in urban areas, whereas primary angle closure glaucoma (PACG) seems to be more prevalent in rural areas 18.…”

Section: Discussioncontrasting

confidence: 81%

“…However, the global prevalence of glaucoma in the population aged 40-80 years is 3.54%, and it is 7% in Africa, which is much higher than the rate in China, reported in both our study and other studies. 1,17 In addition, although our data showed that there was no difference between the prevalence of glaucoma in urban and rural areas, other studies have indicated that POAG is more prevalent in urban areas, whereas primary angle closure glaucoma (PACG) seems to be more prevalent in rural areas. 18 When considering the effect of age, previous studies have found that middle-aged, rather than elderly, individuals had a higher prevalence of glaucoma.…”

Section: Discussioncontrasting

confidence: 73%

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Prevalence and Risk Factors of Glaucoma Among Chinese People From the China Health and Retirement Longitudinal Study

Sun

Zhao

et al. 2022

Journal of Glaucoma

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Précis: This study demonstrated the prevalence of self-reported glaucoma and its strong association with preexisting systemic chronic diseases in China using the baseline data from China Health and Retirement Longitudinal Study (CHARLS), a nationwide population-based cohort. Purpose: The purpose of this study is to estimate the prevalence of self-reported glaucoma and its risk factors using data from the CHARLS. Materials and Methods: Data on age, sex, area of residence, education, marital status, health-related behaviors, and preexisting comorbidities for this cross-sectional study were retrieved from the CHARLS for 17,713 subjects who completed a questionnaire between June 2011 and March 2012. The prevalence of glaucoma was estimated, and a multivariate weighted analysis was performed to estimate the odds ratios (ORs) of its risk factors. Results: Of 16,599 respondents (93.7%) who answered questions regarding glaucoma and their history of systemic chronic diseases, 314 (1.89%) reported having glaucoma before the index date. Qinghai and Beijing had the highest prevalence of glaucoma in China. Glaucoma was significantly associated with hypertension [OR: 1.362; 95% confidence interval (CI), 1.801–2.470], diabetes (OR: 2.597; 95% CI, 1.661–10.207), dyslipidemia (OR: 1.757; 95% CI, 1.157–3.650), lung disease (OR: 2.098; 95% CI, 1.674–6.527), stroke (OR: 5.278; 95% CI, 1.094–25.462), heart disease (OR: 1.893; 95% CI, 1.237–3.363), and health-related behaviors such as smoking and alcohol consumption after adjusting for age, sex, area, education, marital status, and medical insurance. Conclusions: Geographic variation in the prevalence of self-reported glaucoma and its strong association with preexisting systemic chronic diseases were observed, suggesting that in addition to ophthalmological examinations, regular physical examinations are necessary for glaucoma patients, especially in areas of high incidence. Appropriate strategies to improve preventive measures for glaucoma are recommended for the Chinese population.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussioncontrasting

confidence: 73%

Prevalence and Risk Factors of Glaucoma Among Chinese People From the China Health and Retirement Longitudinal Study

Sun

Zhao

et al. 2022

Journal of Glaucoma

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“…Interestingly, consistent with previous reports [18,26], AH and serum samples from male cataract patients contained significantly higher levels of GDF15 relative to female patients, suggesting a definitive gender difference in GDF15 levels. Coincidently, the gender prevalence of open angle glaucoma is mixed, but some studies have reported higher rates in males compared to females [1,27,28]. However, within POAG patients, there was no statistical difference in AH GDF15 levels between male and female patients.…”

Section: Discussionmentioning

confidence: 93%

Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients

Maddala

Karnam

et al. 2022

JCM

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Dysregulated levels of growth/differentiation factor-15 (GDF15), a divergent member of the transforming growth factor-beta super family, have been found to be associated with the pathology of various diseases. In this study, we evaluated the levels of GDF15 in aqueous humor (AH) and serum samples derived from primary open-angle glaucoma (POAG) and age- and gender-matched non-glaucoma (cataract) patients to assess the plausible association between GDF15 and POAG. GDF15 levels were determined using an enzyme-linked immunosorbent assay, and data analysis was performed using the Wilcoxon rank sum test, or the Kruskal–Wallis test and linear regression. GDF15 levels in the AH (n = 105) of POAG patients were significantly elevated (by 7.4-fold) compared to cataract patients (n = 117). Serum samples obtained from a subgroup of POAG patients (n = 41) also showed a significant increase in GDF15 levels (by 50%) compared to cataract patients. GDF15 levels were elevated in male, female, African American, and Caucasian POAG patients. This study reveals a significant and marked elevation of GDF15 levels in the AH of POAG patients compared to non-glaucoma cataract control patients. Although serum GDF15 levels were also elevated in POAG patients, the magnitude of difference was much smaller relative to that found in the AH.

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CRISPR-CasRx-mediated disruption of Aqp1/Adrb2/Rock1/Rock2 genes reduces intraocular pressure and retinal ganglion cell damage in mice

Yao,

Zeng,

et al. 2024

Nat Commun

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Glaucoma affects approximately 80 million individuals worldwide, a condition for which current treatment options are inadequate. The primary risk factor for glaucoma is elevated intraocular pressure. Intraocular pressure is determined by the balance between the secretion and outflow of aqueous humor. Here we show that using the RNA interference tool CasRx based on shH10 adenovirus-associated virus can reduce the expression of the aqueous humor circulation related genes Rock1 and Rock2, as well as aquaporin 1 and β2 adrenergic receptor in female mice. This significantly reduced intraocular pressure in female mice and provided protection to the retina ganglion cells, ultimately delaying disease progression. In addition, we elucidated the mechanisms by which the knockdown of Rock1 and Rock2, or aquaporin 1 and β2 adrenergic receptor in female mice, reduces the intraocular pressure and secures the retina ganglion cells by single-cell sequencing.

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Prevalence of primary open-angle glaucoma in a Somalia population

Cited by 4 publications

References 25 publications

Prevalence and Risk Factors of Glaucoma Among Chinese People From the China Health and Retirement Longitudinal Study

Prevalence and Risk Factors of Glaucoma Among Chinese People From the China Health and Retirement Longitudinal Study

Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients

CRISPR-CasRx-mediated disruption of Aqp1/Adrb2/Rock1/Rock2 genes reduces intraocular pressure and retinal ganglion cell damage in mice

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