Prevalence of Prediabetes and Type 2 Diabetes in Children With Nonalcoholic Fatty Liver Disease

Newton, Kimberly P.; Hou, Jiayi; Crimmins, Nancy A.; Lavine, Joel E.; Barlow, Sarah E.; Xanthakos, Stavra A.; Africa, Jonathan A.; Behling, Cynthia; Donithan, Michele; Clark, Jeanne M.; Schwimmer, Jeffrey B.

doi:10.1001/jamapediatrics.2016.1971

Cited by 190 publications

(174 citation statements)

References 41 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…In 2016, Newton et al [29] published the first multicenter study in children and adolescents with nonalcoholic fatty liver disease (NAFLD) assessing the prevalence of prediabetes and T2D. Children with prediabetes and T2D were at 2 and 3 times (respectively) greater risk of nonalcoholic steatohepatitis than the normal-glucose group [29]. These data reflect an earlier study, which also measured liver triglyceride content and showed that children with T2D were twice as likely to have hepatic steatosis compared with weight-matched normoglycemic controls [11].…”

Section: Hepatologymentioning

confidence: 99%

“…Adolescent girls (14-19 years of age) with at least [11,29,30,44] -Mental health/psychiatry [34]: psychosis [36], depression [5,35], autism spectrum disorder [33], binge eating [37,38] 3 delayed menstrual cycles were 6.5 times more likely to develop impaired fasting glucose and T2D when they were young adults (19-24 years of age) than those who never had a delayed cycle [25]. Similarly, the broad symptom of irregular menses was present in 20.5% of girls with T2D, which appeared higher than prevalence rates for healthy populations [26].…”

Section: Less-known Comorbid Associations With Youth-onset T2dmentioning

confidence: 99%

“…Liver disease may have many underlying causes, but it is associated with adult and youth-onset T2D [29]. In 2016, Newton et al [29] published the first multicenter study in children and adolescents with nonalcoholic fatty liver disease (NAFLD) assessing the prevalence of prediabetes and T2D.…”

Section: Hepatologymentioning

confidence: 99%

Section: Hepatologymentioning

confidence: 99%

“…To date, there is no prospective longitudinal study that investigated if NAFLD precedes or follows development of youth-onset T2D, but some evidence suggests that NAFLD comes first [29]. Systemic insulin resistance may be important in the pathology of both diseases.…”

Section: Hepatologymentioning

confidence: 99%

See 4 more Smart Citations

Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises

2019

View full text Add to dashboard Cite

Background: Youth-onset type 2 diabetes (T2D) is increasing in many countries, creating large personal and societal burdens. While many primary health-care professionals (HCPs) are aware of the classic symptoms of T2D, there are several other manifestations that could indicate its presence. Summary: This narrative review summarizes information on these symptoms and indicators, focusing on those less well known. The classic symptoms and comorbidities include frequent urination, excessive thirst, metabolic syndrome, and obesity. In addition to these, the presence of dermatological (e.g., acanthosis nigricans, granuloma annulare, necrobiosis lipoidica diabeticorum, and scleredema), gynecological (e.g., polycystic ovary syndrome, oligomenorrhea, and vulvovaginitis), hepatological (e.g., nonalcoholic fatty liver disease), and psychiatric diseases (e.g., psychosis, depression, and autism) could indicate that a patient has T2D or is at increased risk of T2D. Other less well-known indicators include abnormal blood tests (e.g., oxidized lipids, inflammation markers, hepatokines, and adipokines), prescriptions for antipsychotic medications or statins, and disrupted sleep patterns. Key Message: Due to the diversity of T2D manifestations in young people, primary HCPs need to remain alert to its possible presence.

show abstract

Section: Hepatologymentioning

confidence: 99%