Prevalence of prediabetes and modifiable factors in an ethnic group of Mexico: the Comcáac Project

Robles-Ordaz, Mónica D.; Gallegos-Aguilar, Ana Cristina; Urquídez-Romero, René; Díaz-Zavala, Rolando Giovanni; Lavandera-Torres, Marcos Gerardo; Esparza-Romero, Julián

doi:10.1017/s1368980017002658

Cited by 19 publications

(26 citation statements)

References 28 publications

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“…They are the smallest population in the area; they have never exceeded one thousand inhabitants and they represent the North extreme point of genetic diversity. Even when they live in a natural environment, westernization permeates, changing traditional forms of nutrition and resulting in health problems, such as high adult diabetes prevalence [13]. The high obesity prevalence shown by boys in this study (25.9%) is a sign of the beginning of the abovementioned health problems in adults.…”

Section: Discussionmentioning

confidence: 54%

Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children

Costa-Urrutia

Abud²,

Franco‐Trecu

et al. 2020

IJMS

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In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children.

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Section: Discussionmentioning

confidence: 54%

Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children

Costa-Urrutia

Abud²,

Franco‐Trecu

et al. 2020

IJMS

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“…Among the 61 included records, 43 were literature reviews [47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89], and 18 were original studies [90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107] (Table 1). Among the literature reviews, most ( n = 26) used historical, archaeological, or ethnographic data to describe the TMexD.…”

Section: Resultsmentioning

confidence: 99%

“…Among all 61 studies included to define the diet, six of them also assessed the relationship between the TMexD and NCD health outcomes [78,79,93,95,100,103]. Three were cross-sectional studies [93,95,103], one was a case-control study [100], one was a cohort study [78] and one was a randomised cross-over feeding trial (RCT) [79].…”

Section: Resultsmentioning

confidence: 99%

Definition of the Traditional Mexican Diet and Its Role in Health: A Systematic Review

et al. 2019

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Promoting traditional diets could potentially reduce the current high rates of non-communicable diseases (NCDs) globally. While the traditional Mexican diet (TMexD) could be specifically promoted in Mexico, a concise definition of the TMexD and evidence of its association with NCDs are needed before its promotion. To evaluate what constitutes this diet pattern, we aimed to systematically review, for the first time, how the TMexD has been described in the literature to date. A secondary aim was to examine whether the TMexD, as described by available definitions, is associated with NCD outcomes. We searched for records describing a whole TMexD up to July 2019 in 12 electronic databases, reference lists, a relevant journal, and by contacting experts on the topic. We reported the results using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. We included 61 records for the definition of the diet and six for the association with NCD outcomes. The food groups characterising the TMexD that were consistently mentioned in all the study subgroups were grains and tubers, legumes, and vegetables; specific foods included maize, beans, chile, squash, tomato, and onion. Other groups also mentioned, although with lesser frequency, were maize products, fruits, beverages, fish and seafood, meats, sweets and sweeteners, and herbs and condiments. Only a few studies reported on the frequency of consumption or the amounts in which these foods were consumed in the TMexD. It was not possible to reach strong conclusions for the association between adherence to the TMexD and NCD outcomes. The TMexD was weakly associated with developing breast cancer, not associated with triglyceride levels, and inconsistently associated with obesity and diabetes outcomes. However, results were limited by the small number of studies (n = 6), of which most were of observational nature and evaluated diets using different TMexD definitions. These findings provide systematically identified evidence of the characteristics of the TMexD. More studies are needed to ascertain the exact quantities by which foods were consumed in the TMexD in order to establish whether this dietary pattern is associated with health and should be promoted within the Mexican population.

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“…There are limited data regarding the prevalence of pre-diabetes in Mexico, with smaller studies providing estimates ranging from 14% to 47% [46][47][48], and another study with a high-risk population reporting a prevalence as elevated as 74% [49]. In the United States (U.S.), an estimated 84 million American adults, more than 1 in 3, have pre-diabetes, yet only about 10% are aware they have the condition [50].…”

Section: Competing Interestsmentioning

confidence: 99%

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

et al. 2020

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To determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers. Methods Participants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively. Results Mean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The crosssectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among

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Prevalence of prediabetes and modifiable factors in an ethnic group of Mexico: the Comcáac Project

Cited by 19 publications

References 28 publications

Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children

Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children

Definition of the Traditional Mexican Diet and Its Role in Health: A Systematic Review

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

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