Prevalence of Posttransplantation Lymphoproliferative Disease in Pediatric Liver Transplant Recipients

The Perinatal Infection of Cytomegalovirus Is an Important Etiology for Biliary Atresia in China

“…Recent patient-and animal-based experiments indicate that interactions between infectious agents and inflammatory circuits may be important pathogenic mechanisms of the disease. 13,14 Therefore, we hypothesized that, to support Landing's theory, we should detect one virus in almost every liver biopsy if testing simultaneously for the most common hepatotropic DNA viruses, and we had a sufficient number of patients in our study. We, indeed, observed a higher incidence of viral infection in our study.…”

Post-Transplant Lymphoproliferative Disease – PTLD

“…The median time from the first symptoms to the initial treatment was 9. 7 days (Wiederkehr et al, 2010). In general, however, PTLD is remarkable for a short post-transplantation time of onset.…”

“…(Praghakaran, 1999) In our series of 7 liver transplants in small children with PTLD, median age at transplantation was 35.14 months, and the mortality was 57%. (Wiederkehr et al, 2010) The heterogeneity of these reports exemplifies the variable results seen with different treatment regimens among different centers and argues for standardized multicenter therapeutic trials against this disease. According to Nalesnik's series of 256 patients with PTLD, the overall 2-year actuarial survival is 90%, and the overall actuarial 5-year survival is 77%.…”

FDG PET/CT Findings of the Recurrent Posttransplantation Lymphoproliferative Disorder in a Pediatric Liver Transplant Recipient With Right Leg Pain as the Only Complaint

“…16 Our case indicated that pain in an appendicular bone can also be a presentation of PTLD and FDG PET/CT can help to reach an early diagnosis which had shown to associate with a better prognosis due to early intervention than those who received therapy late. 12 …”