Prevalence of Post-COVID-19 Cough One Year After SARS-CoV-2 Infection: A Multicenter Study

Abstract

This multicenter study presents prevalence data and associated risk factors of post-COVID-19 cough one year after hospital discharge in COVID-19 survivors. Individuals recovered from COVID-19 at three public hospitals in Madrid (Spain) were scheduled for a telephonic interview. They were systematically asked about the presence of respiratory symptoms, e.g., fatigue, dyspnea, chest pain, and cough after hospital discharge. Clinical and hospitalization data were collected from hospital records. Overall, 1,950 patients (47% women, mean age:61, SD:16 years) were assessed at 11.2 months (SD 0.5) after hospital discharge. Just 367 (18.8%) were completely free of any respiratory post-COVID -19 symptom. The prevalence of long-term cough, chest pain, dyspnea, and fatigue was 2.5%, 6.5%, 23.3%, and 61.2%, respectively. Clinical and hospitalization factors were not associated with long-term post-COVID-19 cough. In conclusion, the prevalence of post-COVID-19 cough one year after SARS-CoV-2 infection was 2.5% in subjects who had survived hospitalization for COVID-19. No clear risk factor associated to long-term post-COVID-19 cough was identified.

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Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China

“…11 In another study of COVID-19 survivors 1 year after hospital discharge, post-COVID-19 symptoms included fatigue, dyspnea, chest pain, and cough. 12 There are currently no agreed-upon measures to assess the symptom burden of COVID-19. However, the Chronic Obstructive Pulmonary Disease (COPD) Assessment Test (CAT), an 8-item questionnaire designed to quantify health status impairment in COPD patients, 13 demonstrated a high CAT score in patients with COVID-19 in the weeks following their admission.…”

Innate Receptors Expression by Lung Nociceptors: Impact on COVID-19 and Aging

“…Some COVID-19 patients manifest persistent symptoms even months after the initial insults. These symptoms, known as post-acute COVID-19 syndrome, include recurrent cough which indicates that sensory neurons can be chronically activated ( 103 , 104 ). Although this reflex contributes to viral spread during acute infection through the dispersion of virus-containing droplets from the airways, it is less clear how and why chronic cough develops once the virus is eliminated.…”