Abstract:In this study, the prevalence of polyhydramnios in the third trimester was lower than in previous studies, as well as being associated with a better prognosis. This may have been the result of a combination of several factors. These include the introduction of multi-level ultrasound screening for fetal abnormality, and the improved care of diabetic women, and mothers with rhesus iso-immunisation.
“…It causes the decrease production of amniotic fluid by increase absorption of fluid by lungs, reducing the urine output and also impairs the prostaglandin mediated response of renal vasculature 7,10,11 . The frequency of polyhydramnios was 1.7% in our study which corresponds with the other study mentioned in literature which showed the incidence of 1-2% respectively [2][3][4][5][6] . The causes of polyhydramnios in our study was mainly idiopathic which was similar to study performed by Maymon et al 12 , Tariq S et al 13 and Panting Kemp et al 14 .…”
Section: Discussionsupporting
confidence: 90%
“…Polyhydramnios is one of the dreaded complication in obstetric practice, as it affects not only mother but also the fetus. The overall incidence is 1-2% [2][3][4][5][6] . It causes maternal complications like antepartum hemorrhage, respiratory embarrassment, abnormal presentation, uterine dysfunction and also postpartum hemorrhage.…”
Objective: To observe the role of indomethacin in polyhydramnios.Method: This was a prospective, longitudinal and analytical study conducted in Kathmandu University Hospital, Dhulikhel from 1st July 2011 to 1st of December 2012. There were 32 patients included in the study. Indomethacin was administered orally at the dose of 25 mg three times a day for 1 week. The patients were admitted for observation of clinical symptoms, fundal height, fetal status and amniotic fluid index measurement. After the delivery, baby was investigated for any abnormality of fetal circulation.Results: There were total of 2700 deliveries in 1 year. Among them 46 cases were of polyhydramnios. The frequency was 1.7%. Among the 46 cases, 32 (69.6%) were idiopathic who were included whereas 8 (17.4%) were of diabetes mellitus, 4 (8.7%) were Rh isoimmunisation, and 2 (4.3%) were fetal anomalies. The mean age group was 24.5+/ -4.2 years. There were total 10 (31.3%) patients presented at 29 weeks of gestation whereas only 5 (15.7%) patients at 32 weeks of gestation. Regarding the gravid index, 17 (53.1%) patients were primigravida. There was statistically significant reduction in amniotic fluid volume following 1 week administration of indomethacin.
Conclusion:Though there are many modes of treatment for polyhydramnios, the 1 week therapy with indomethacin is equally beneficial.
“…It causes the decrease production of amniotic fluid by increase absorption of fluid by lungs, reducing the urine output and also impairs the prostaglandin mediated response of renal vasculature 7,10,11 . The frequency of polyhydramnios was 1.7% in our study which corresponds with the other study mentioned in literature which showed the incidence of 1-2% respectively [2][3][4][5][6] . The causes of polyhydramnios in our study was mainly idiopathic which was similar to study performed by Maymon et al 12 , Tariq S et al 13 and Panting Kemp et al 14 .…”
Section: Discussionsupporting
confidence: 90%
“…Polyhydramnios is one of the dreaded complication in obstetric practice, as it affects not only mother but also the fetus. The overall incidence is 1-2% [2][3][4][5][6] . It causes maternal complications like antepartum hemorrhage, respiratory embarrassment, abnormal presentation, uterine dysfunction and also postpartum hemorrhage.…”
Objective: To observe the role of indomethacin in polyhydramnios.Method: This was a prospective, longitudinal and analytical study conducted in Kathmandu University Hospital, Dhulikhel from 1st July 2011 to 1st of December 2012. There were 32 patients included in the study. Indomethacin was administered orally at the dose of 25 mg three times a day for 1 week. The patients were admitted for observation of clinical symptoms, fundal height, fetal status and amniotic fluid index measurement. After the delivery, baby was investigated for any abnormality of fetal circulation.Results: There were total of 2700 deliveries in 1 year. Among them 46 cases were of polyhydramnios. The frequency was 1.7%. Among the 46 cases, 32 (69.6%) were idiopathic who were included whereas 8 (17.4%) were of diabetes mellitus, 4 (8.7%) were Rh isoimmunisation, and 2 (4.3%) were fetal anomalies. The mean age group was 24.5+/ -4.2 years. There were total 10 (31.3%) patients presented at 29 weeks of gestation whereas only 5 (15.7%) patients at 32 weeks of gestation. Regarding the gravid index, 17 (53.1%) patients were primigravida. There was statistically significant reduction in amniotic fluid volume following 1 week administration of indomethacin.
Conclusion:Though there are many modes of treatment for polyhydramnios, the 1 week therapy with indomethacin is equally beneficial.
“…Phelan et al described quantification of amniotic fluid using the amniotic fluid index (AFI). 8 The four-quadrant technique termed AFI is in which a vertical pocket of amniotic fluid, free of umbilical cord, in each of four equal uterine quadrant was summated. An amniotic fluid volume more than two standard deviation below the mean for specific gestational age or volume reduced below the 5th percentile for particular gestational age would define oligohydramnios.…”
Aim: To assess and compare the perinatal outcome among mothers with normal and abnormal amniotic fluid volume. Methodology: A prospective comparative study was conducted for a period of one year from January 2016 to December 2016. Group I consist of 50 patients with normal amniotic fluid and group II consists of 50 patients with either oligohydramnios or polyhydramnios. Amniotic fluid index (AFI) was calculated using Phalen's four quadrant technique using ultrasound. The perinatal outcome was judged by assessing the fetal distress predicted by abnormal fetal heart rate (FHR) or meconium stained liquor, one minute and 5 minute Apgar score, frequency of admission to neonatal intensive care unit (NICU), baby weight of less than 10th percentile for gestation age and perinatal mortality. Results: Induction of labour, caesarean section and meconium stained liquor was found to be most common among the patients in group II (abnormal AFI) in comparison with normal AFI subjects and similarly the perinatal outcome measures like low birth weight, increased frequency of admission to NICU due to respiratory distress and a low APGAR score was more commonly found in abnormal AFI group and the difference was found to be statistically significant. Conclusion: AFI measurement in antepartum or intrapartum period can help to identify women who need increased antepartum surveillance for pregnancy complications and such women should be managed in a special unit to combat the complications effectively.
“…Finally, 20% of polyhydramnios cases are related to diabetes. 3,12 Because polyhydramnios in such pregnancies is not considered idiopathic, those pregnancies were excluded from other studies and their outcome is not clear.…”
OBJECTIVE: To investigate the short-and long-term outcomes of children from pregnancies complicated with polyhydramnios, defined as amniotic fluid index (AFI) >24 cm, and with a normal detailed ultrasound examination.
METHODS:This retrospective cohort study examined 134 children aged 4 to 9 years with polyhydramnios and normal detailed ultrasound examination during pregnancy compared with 268 controls with normal AFI and normal detailed ultrasound examination matched for maternal age, year of delivery, gestational week at delivery, and presence or absence of diabetes. The primary outcome was the rate of malformations diagnosed postnatally. Additional outcomes were obstetrics outcomes, genetic syndromes, and neurodevelopment.
RESULTS:Polyhydramnios was associated with increased risk for cesarean delivery (CD) and birth weight >90th percentile. This elevation in CD was attributed to increased rate of elective CD due to suspected macrosomia. Polyhydramnios was associated with increased risk for congenital malformations (n = 25 [19%] compared with 27 [10%], respectively; P = .016) without a statistically significant increase in the rate of major malformations (11 [8%] vs. 10 [4%]; P = .057). Genetic syndromes were more prevalent in the polyhydramnios group (5 [3.7%] vs. 2 [0.75%]; P = .043), as were neurologic disorders and developmental delay (9.7% vs. 3%; P = .004).
CONCLUSIONS:Despite a normal detailed ultrasound examination, polyhydramnios is associated with increased rate of fetal malformations, genetic syndromes, neurologic disorders, and developmental delay, which may be diagnosed only after birth.
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