Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis

Long, Caiyi; Feng, Haoyue; Wen, Deliang; Chen, Xin; Zhao, Yuge; Li, Ying; Yue, Rensong

doi:10.3389/fendo.2022.980405

Cited by 14 publications

(4 citation statements)

References 72 publications

(127 reference statements)

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“…Metformin is recommended to treat metabolic disorders that are common in PCSO, either as a standalone treatment or as an additional therapy [ 199 , 200 ]. This endorsement is based on the fact that nearly half of women with PCOS are overweight or obese and may have impaired glucose tolerance, hyperinsulinemia, or overt T2DM [ 201 , 202 ]. It is important to note that metformin aids in regulating menstrual cycles and improving fertility [ 196 , 199 ].…”

Section: Resultsmentioning

confidence: 99%

View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences

Froldi

2024

Pharmaceuticals

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Metformin is a synthetic biguanide used as an antidiabetic drug in type 2 diabetes mellitus, achieved by studying the bioactive metabolites of Galega officinalis L. It is also used off-label for various other diseases, such as subclinical diabetes, obesity, polycystic ovary syndrome, etc. In addition, metformin is proposed as an add-on therapy for several conditions, including autoimmune diseases, neurodegenerative diseases, and cancer. Although metformin has been used for many decades, it is still the subject of many pharmacodynamic and pharmacokinetic studies in light of its extensive use. Metformin acts at the mitochondrial level by inhibiting the respiratory chain, thus increasing the AMP/ATP ratio and, subsequently, activating the AMP-activated protein kinase. However, several other mechanisms have been proposed, including binding to presenilin enhancer 2, increasing GLP1 release, and modification of microRNA expression. Regarding its pharmacokinetics, after oral administration, metformin is absorbed, distributed, and eliminated, mainly through the renal route, using transporters for cationic solutes, since it exists as an ionic molecule at physiological pH. In this review, particular consideration has been paid to literature data from the last 10 years, deepening the study of clinical trials inherent to new uses of metformin, the differences in effectiveness and safety observed between the sexes, and the unwanted side effects. For this last objective, metformin safety was also evaluated using both VigiBase and EudraVigilance, respectively, the WHO and European databases of the reported adverse drug reactions, to assess the extent of metformin side effects in real-life use.

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Section: Resultsmentioning

confidence: 99%

View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences

Froldi

2024

Pharmaceuticals

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“…Thus, on the other hand, the prevalence of PCOS among women with and obesity is 26%. It was determined higher glucose blood level and insulin level in obese PCOS patients than in obese women without this neuroendocrine syndrome, even when PCOS individuals were younger [32].…”

Section: г і н е к о л о г і яmentioning

confidence: 94%

The modern pathogenetic challenges of polycystic ovary syndrome

Pakharenko,

Zhylka,

Shcherbinska

et al. 2024

RHW

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Polycystic ovary syndrome (PCOS) is one of the neuroendocrine syndromes in women of reproductive age. In the pathogenesis of its development a great importance is paid to the hormonal disbalance, metabolic changes, overweight and obesity, diabetes mellitus, insulin resistance, genetic factors, etc. Very often, PCOS is accompanied by infertility, cardiovascular risks, diabetes mellitus.The article is devoted to a review of modern scientific literature about the last researches devoted to the mechanisms of metabolic disorders which are connected with insulin resistance, overweight and obesity, also, with psychological disturbance and stress. The article describes the specific of psychological conditions in PCOS patients. On the basis of the analyzed scientific publications the connection between hormonal disbalance, psychological disorders, overweight, obesity and lipidogram parameters is presented.Also, the researches about gut and vaginal microbiota are described in this paper. The last studies demonstrate the significant changes of human microbiome in the development and course of polycystic ovary syndrome. The article presents the concepts of the difference in the composition of the gut and vagina microbiota in women with this neuroendocrine syndrome.The pathogenetic mechanisms of the role of the microbiota in the processes of PCOS pathogenesis, namely, the regulation of the immune response and inflammation processes in this pathology, are described. It has been shown that in women with PCOS there are differences in the microflora composition of the intestines, manifested by a decreased concentration of Lactobacillus and the presence of a variety of other microorganisms compared to the healthy women.Thus, the main pathogenetic links of PCOS development are closely connected with each other. That is why multimodal approaches for study of PCOS and for management of the patients with PCOS are extremely important.

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“…Insulin resistance plays a key role in the pathophysiology of PCOS and was reported in up to 70% of patients with the disease [ 48 , 49 ]. Moreover, metformin was found to be effective in the management of patients with PCOS [ 50 ]. In addition to insulin resistance, uptake of glucose is defective in PCOS women, due to a reduction in GLUT-4, a glucose transporter.…”

Section: Clinical Overlap Between Asthma and Pcosmentioning

confidence: 99%

The “Asthma-Polycystic Ovary Overlap Syndrome” and the Therapeutic Role of Myo-Inositol

Guarnieri

Iervolino²,

Cavallone³

et al. 2023

IJMS

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Asthma is a heterogeneous inflammatory disease characterized by abnormalities in immune response. Due to the inherent complexity of the disease and the presence of comorbidities, asthma control is often difficult to obtain. In asthmatic patients, an increased prevalence of irregular menstrual cycles, infertility, obesity, and insulin resistance has been reported. Given that these conditions are also common in patients with polycystic ovary syndrome (PCOS), we propose the definition of “asthma-PCOS overlap syndrome” to indicate a medical condition which shares characteristics of both diseases. The aim of this review is to analyze the links between asthma and PCOS and evaluate the therapeutic role of myo-inositol, a natural compound currently utilized in patients with PCOS, in the management of asthma patients.

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Prevalence of polycystic ovary syndrome in patients with type 2 diabetes: A systematic review and meta-analysis

Cited by 14 publications

References 72 publications

View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences

View on Metformin: Antidiabetic and Pleiotropic Effects, Pharmacokinetics, Side Effects, and Sex-Related Differences

The modern pathogenetic challenges of polycystic ovary syndrome

The “Asthma-Polycystic Ovary Overlap Syndrome” and the Therapeutic Role of Myo-Inositol

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