Prevalence of Pigment Dispersion Syndrome in Patients Seeking Refractive Surgery

Abstract

Purpose: To determine the prevalence of pigment dispersion syndrome (PDS) in patients presenting for vision correcting refractive surgery. Setting: Discover Vision Centers, Kansas City, MO. Design: This is a prospective case series. Materials and Methods: A total of 637 eyes of 319 serial patients who presented seeking refractive surgery were included in this prospective, observational study. Patients underwent routine ophthalmologic examination before refractive surgery. PDS was diagnosed by the presence of a deep anterior chamber, posterior bowing of the irides, Krukenberg spindles, and/or presence of mid-peripheral iris transillumination defects by the same experienced ophthalmologist. The prevalence of PDS and its associated ophthalmic and demographic characteristics were evaluated in those diagnosed. Results: Of the 637 eyes, 165 (25.9%) eyes were diagnosed with PDS. Krukenberg spindles were present in 53 (8.3%) of the total eyes and in 47 (28.5%) eyes that were diagnosed with PDS. Transillumination defects were present in 153 (95%) eyes diagnosed with PDS and 161 (25.2%) total eyes. There was equal distribution between sex in those diagnosed with PDS (male vs. female: 26 vs. 25.8%; P=0.942). Blue colored eyes were most likely to have PDS (35.8% of patients). Conclusions: The prevalence of PDS within the population of patients seeking refractive surgery is likely greater than the general population as a whole. This is most likely the result of self-selection and high association between myopia and PDS. Given that not infrequent sequela can occur from untreated PDS, it is prudent that refractive surgeons be aware of this increased prevalence and perform thorough examinations to properly identify the condition.

Clinical Profile and Demographic Distribution of Pigment Dispersion Syndrome: An electronic medical record-driven big data analytics from an eye care network in India

“…In the US, the prevalence is 2.5% and the incidence is 4.8/100000 population per year [23]. A study involving subjects who were consulting for refractive surgery showed a higher prevalence of 25.9%, although the bias here may be due to the higher number of myopic subjects [24].…”

Clinical profile and demographic distribution of pigment dispersion syndrome: An electronic medical record-driven big data analytics from an eye care network in India

“…[23] A study involving subjects who were consulting for refractive surgery showed a higher prevalence of 25.9%, although the bias here may be due to the higher number of myopic subjects. [24] e "Burn out phase" is the phase which is said to occur approximately 10 years after the onset of the disease and is characterised by a lowering of IOP and stabilisation of the glaucomatous damage. e hypothesis behind this being the enlargement of the anteroposterior diameter of the lens with an increase of distance between the iris and zonular fibres and reduction in pigment release.…”

Clinical diagnosis of presumed SOX2 gonadosomatic mosaicism

“…The prevalence of iris transillumination defects in the general population has not been studied specifically. However, this has been evaluated in individuals seeking refractive surgery (n = 637 eyes) and in a cohort of patients with glaucoma (n = 24) vs controls (n = 23) ( 27 , 28 ). Either none, diffuse, or radial transillumination patterns were found in these individuals; no focal, forme fruste type, transillumination defect were described.…”