Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis

Sun, Juan; Wang, Ya; Zhang, Xiaoyi; Zhu, Shudong; He, Hong

doi:10.1016/j.pcd.2019.12.005

Cited by 66 publications

(68 citation statements)

References 35 publications

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“…The prevalence of DPN was also found to be higher among DM patients who were having diabetes for more than 10 years. This was in line with results of previous studies [13], [14], [17], [20]. As the duration of DM increases, the risk of complications advances and this accelerates if the glycemic control is also poor.…”

Section: Discussionsupporting

confidence: 92%

“…About 42.0% of diabetic patients were found to be suffering from peripheral neuropathy. This was similar to the ndings of other studies on diabetic peripheral neuropathy (DPN) [10], [13][14][15][16].However, this was in contrast to the ndings of Kaewput et al [17] and Perrin et al [18] in which prevalence ranged from 3.0% to 16.6%. The possible reasons for this variation could be different study settings and different classi cation used to diagnose DPN in these studies.…”

Section: Discussionsupporting

confidence: 89%

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Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Bashar¹,

Verma²

2020

Preprint

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Background Diabetic peripheral neuropathy (DPN), a common and troublesome complication in patients with type 2 diabetes mellitus (T2DM), contributes to a higher risk of diabetic foot ulcer and lower limb amputation. These situations can negatively impact the quality of life of affected individuals.Objectives The study aimed to assess prevalence of DPN in patients of type 2 DM from rural North India and associated risk factors. Methods A facility based cross sectional study was carried out among type 2 diabetic patients attending NCD clinic of a secondary care hospital in rural North India. A questionnaire which included socio-demographic details, clinical and laboratory parameters, and the Michigan Neuropathy Screening Instrument (MNSI) for detecting peripheral neuropathy, was administered to 100 consecutive patients. Statistical Package for Social Sciences (SPSS) version 25.0 was used for entering and analyzing data. Bivariate analysis was performed for determining the factors significantly associated with presence of DPN. Results The prevalence of DPN was 42.0%. Male gender, advancing age(≥60 years), longer duration of diabetes (>10 years ), smoking, physical inactivity, obesity, uncontrolled blood pressure, poor A glycaemic control and altered lipid profile were found to be significantly associated with the presence of DPN. Conclusion Prevalence of DPN among type 2 diabetics from rural north India is alarmingly high. There is need of essential screening of all diabetic patients by their primary care provider for early detection of DPN particularly in rural India.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Bashar¹,

Verma²

2020

Preprint

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“…In South Africa for instance as a result of changes in peoples' diet and lifestyle, diabetes has moved from being the fifth leading underlying cause of death in 2013 to now the second most common cause, representing 5.5% of all recorded deaths (Statistics South Africa, 2016;Moosa et al, 2019). T2DM also results in a lower health status and quality of life (Fasanmade and Dagogo-Jack, 2015;da Mata et al, 2016;Adibe et al, 2018;Rwegerera et al, 2018), with high rates of sight threatening retinopathy among diabetic patients in Africa (Glover et al, 2012;Jingi et al, 2015;Cairncross et al, 2017;Pastakia et al, 2017;Lewis et al, 2018) as well as nephropathy (Thomas et al, 2016;Wagnew et al, 2018) and neuropathy (Awadalla et al, 2017;Sun et al, 2020). Overall, populations of African origin appear to have the highest prevalence of microvascular complications of diabetes exacerbated by frequent high blood pressure and inappropriate diabetes control among the diabetes population along with challenges of access to appropriate care (Mbanya and Sobngwi, 2003;Mbanya et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Review of Ongoing Activities and Challenges to Improve the Care of Patients With Type 2 Diabetes Across Africa and the Implications for the Future

et al. 2020

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“…The pattern of occurrence of neuropathies has been elucidated in Table 2. 33.8% of the patients included in the study population had evidence of neuropathy, which was greater than the prevalence found in some Indian studies [32] [33], but was at par with most large scale studies in western populations [34]. The commonest type of neuropathy seen was distal symmetrical sensorimotor polyneuropathy, which was seen in 72.9%, followed by entrapment neuropathies which were seen in 8.33% of cases.…”

Section: Resultsmentioning

confidence: 69%

Prevalence and spectrum of diabetic peripheral neuropathy and its correlation with insulin resistance - An experience from eastern India

Majumdar

Banerjee

Sengupta

et al. 2020

Preprint

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word count: 250 Number of references: 39 Number of tables: 4 Number of figures: 1 All rights reserved. No reuse allowed without permission. ABSTRACT:AIMS Diabetes mellitus is a public health problem worldwide, with diabetic neuropathy (DN) being a common complication. Studies indicate that, neurons can develop insulin resistance (IR) and cannot respond to the neurotrophic properties of insulin. Although studies exist on the relation between DN and glycemic exposure index (GE i ), papers about correlation of DN with IR is rare. This study focused on the prevalence of neuropathies in DM patients and usefulness of IR as a marker of DN. METHODSA cross sectional observational study was done. All patients satisfying American Diabetes Association criteria and none of the exclusion criteria were included. Total sample size was 142. Main parameters studied were glycemic status, neurological examination and nerve conduction study findings. Dyck grading was used for severity of distal symmetric polyneuropathy (DSPN). For statistical analysis, logistic and ordinal logistic regressions were used as appropriate. RESULTS34.5% of the sample had DN, the commonest type being DSPN (72.9%). The study population was equally divided in terms of gender and 88.7% were type 2 diabetic. About 62.5% neuropathic cases were asymptomatic. Occurrence of DN correlated significantly with duration of diabetes, FBS and IR. Age, when adjusted for other risk factors was not significantly correlated to neuropathy. The severity of DSPN correlated significantly with GE i but not with IR. CONCLUSIONSThe prevalence of neuropathy was found to be similar to earlier western studies. This paper further establishes IR as a significant predictor for existence of DN, but it may not affect the progress of the neuropathy.

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Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis

Cited by 66 publications

References 35 publications

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Prevalence and Determinants of Diabetic Peripheral Neuropathy/Foot Syndrome in a rural population of North India

Review of Ongoing Activities and Challenges to Improve the Care of Patients With Type 2 Diabetes Across Africa and the Implications for the Future

Prevalence and spectrum of diabetic peripheral neuropathy and its correlation with insulin resistance - An experience from eastern India

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