Prevalence of Periapical Lesions in Patients with Osteoporosis

Katz, Joseph; Rotstein, Ilan

doi:10.1016/j.joen.2020.10.019

Cited by 26 publications

(20 citation statements)

References 30 publications

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“…however, these data are based on a small sample and will need to be validated in a larger study (Tables 3 and 4). The prevalence of AP in patients on BPs was the lowest (Table 3), and this is in full agreement with the results from Katz and Rotstein, who went further and identified that specifically Risedronate had the best impact on the smallest incidence of AP (Katz & Rotstein, 2021). It may be speculated that BPs are not relevant for the progression of AP, or alternatively that BPs may contribute to limiting the size of the lesions because of their antiresorptive properties (Rao et al, 2017;Silva et al, 2020;Song et al, 2016;Wayama et al, 2015;Xiong et al, 2007).…”

Section: Discussionsupporting

confidence: 89%

“…(1.78% vs. 0.52%, OR = 3.36) (Katz & Rotstein, 2021). The strength of these data comes from the large population of the study, but, on the other hand, other possible underlying conditions of the patients were not known, and the diagnostic techniques used to assess AP were not thoroughly specified.…”

Section: Discussionmentioning

confidence: 96%

“…Another consideration is that the average number of teeth in the O patients of this investigation was lower than in C (22.25 vs. 24.57, p = .03), finding that could be related to a lower survival rate in the teeth of osteoporotic patients, as well as to the higher average age of the study group (Table 2 ). In contrast, Katz and Rotstein in a study based on integrated data of hospital patients with a consequent large sample (42.292) have reported that the prevalence of AP is significantly higher in osteoporotic patients (1.78% vs. 0.52%, OR = 3.36) (Katz & Rotstein, 2021 ). The strength of these data comes from the large population of the study, but, on the other hand, other possible underlying conditions of the patients were not known, and the diagnostic techniques used to assess AP were not thoroughly specified.…”

Section: Discussionmentioning

confidence: 98%

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Periapical status in patients affected by osteoporosis: A retrospective clinical study

Cadoni

Ideo

Marongiu

et al. 2022

Clinical & Exp Dental Res

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Objectives: To assess the periapical status in patients with osteoporosis (OP) treated with denosumab (D), bisphosphonates (BPs), or not on medication, and to understand if these conditions influence the prevalence and the progression of apical periodontitis (AP). Material and Methods: Seventy-six patients with OP alone or treated with D, or BPs, formed the study group (O), and those from 76 patients matched for age and sex, without diseases, and not taking medications, constituted the control (C) in this retrospective case−control study. The data from the complete clinical and radiographic examination, medical history, decayed, missing, and filled teeth (DMFT), and periapical index score (PAI) were recorded for each patient. Wilcoxon rank test, χ 2 , and Student's t test were used as appropriate. Results: The prevalence of AP was similar in O and C. Furthermore, AP was significantly more frequent in root canal-treated teeth in O patients (p = .03).Conclusions: OP does not appear to be associated with the development of AP.Moreover, the increased prevalence of AP in root canal-treated teeth in O patients highlights a possible relationship between the healing dynamics of the disease post-therapy and the patients' medication. A larger sample is needed to confirm these findings.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

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Periapical status in patients affected by osteoporosis: A retrospective clinical study

Cadoni

Ideo

Marongiu

et al. 2022

Clinical & Exp Dental Res

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“…López‐López et al (2015) investigated the relationship between RPL and bone mineral density in post‐menopausal women, finding that low bone mineral density was marginally associated with a higher frequency of RPL; 25% of osteopenic and osteoporotic women showed at least one radiolucent periapical lesion, whereas this percentage was only 7.4% in the control group. Another study investigated the prevalence of periapical lesions in patients with osteoporosis, compared with the general population of the hospital, finding that the prevalence of periapical lesions was significantly higher in osteoporotic patients (Katz & Rotstein, 2021).…”

Section: Resultsmentioning

confidence: 99%

Impact of systemic health on treatment outcomes in endodontics

et al. 2022

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Background:The healing of periapical lesions after root canal treatment (RCT) is not the result of the curative action of the treatment. The process of healing begins with inflammation, and is resolved by the clearance of the immunogen that induces the immune response. Then, the periapical tissue itself carries out the healing of the periapical lesion, by repair or by a combination of repair and regeneration, depending on the host's reparative response working properly. The ultimate objective of RCT is to achieve wound healing by removing the source of bacterial antigens and toxins, allowing chronic inflammatory tissue to become reparative tissue. Some systemic conditions increase the susceptibility of the host to infection or impair the tissue reparative response, maintaining the inflammatory process and periapical bone resorption after RCT. This can cause the failure of RCT and even the need for extraction of the affected tooth. Objective:To analyse the scientific literature on the possible influence of systemic conditions on the treatment outcomes in endodontics, as well as to discuss the biological mechanisms that may be involved. Methods:The search was carried out in PubMed, SCOPUS and EMBASE. The inclusion criteria established were original scientific articles reporting data about some systemic condition in relation to treatment outcomes in endodontics, including clinical studies and studies carried out in animal models.Results: Systemic factors (age, nutrition, stress, hormones, smoking habits), and systemic diseases, such as diabetes, cardiovascular diseases, osteoporosis, HIV infection, inflammatory bowel disease, and others, can influence or interfere in the repair of periapical tissues after RCT.Discussion: Some of these systemic diseases can alter bone turnover and fibroblast function, preventing or delaying periapical wound healing. Others can alter the microvasculature, reducing nutrients and oxygen supply to periapical tissues. As a result, these systemic conditions can decrease the success rate of RCT and provoke incomplete wound healing (typically granulomatous tissue formation) in the periapical region.

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“…It has also been related to a lesser degree with other systemic diseases, such as: hypertension [18], osteoporosis [19][20][21], multiple myeloma [21], cardiovascular diseases [22,23], metabolic syndrome [24], and transplanted [25] and coagulation disorders [5]. There is a significant association between ICD (Inherited Coagulation Disorders) and the presence of radiographically diagnosed periapical lesions, an aspect that shows that coagulopathies hardly can be regarded as a primary cause of root canal infection and AP [10].…”

Section: Ap and Systemic Diseasesmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Apical Periodontitis and Other Oral Health Variables: A Case-Control Study

et al. 2022

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Background: The relationship between chronic inflammatory diseases and their comorbidities and correlation with periodontal diseases has become an increasing focus of research. Objectives: The aim of this case-control study was to conclude if patients suffering from COPD (Chronic Obstructive Pulmonary Disease) tend to have more AP (Apical Periodontitis) than non-COPD patients. Materials and Methods: The study was conducted on 30 patients assigned as cases, associated with 30 control patients linked by age (+/−5 years) and sex. Results: A total of 60 patients were recorded, and a total of 12 radiographic variables were analyzed. A total of 43 (71.7%) patients were registered with PAI (Periapical Index) ≥ 3, and there was a slightly tendency in the patients from the control group 22 (73.3%) compared to those from the cases 21 (70%), respectively (p > 0.05). Conclusions: It was concluded that there was not a significant association between the levels of PAI (Periapical Index) ≥ 3 per patient in those suffering from COPD. In fact, it could be concluded that patients diagnosed with COPD tend to have more teeth with PAI ≥ 3, more endodontic treatments and their periodontitis tended to accumulate more caries. Clinical Significance: This study establishes, in a case-control study, some specific aspects of oral health in patients with COPD, as well as analyzing the importance of oral health in this disease.

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Prevalence of Periapical Lesions in Patients with Osteoporosis

Cited by 26 publications

References 30 publications

Periapical status in patients affected by osteoporosis: A retrospective clinical study

Periapical status in patients affected by osteoporosis: A retrospective clinical study

Impact of systemic health on treatment outcomes in endodontics

Chronic Obstructive Pulmonary Disease and Apical Periodontitis and Other Oral Health Variables: A Case-Control Study

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