Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age, Sex, and Helicobacter pylori Infection

Abstract

We investigated the prevalence of peptic ulcer in dyspeptic patients in China to analyze the influence of age, sex, and Helicobacter pylori (H. pylori) infection. The results showed that the prevalence of gastric and duodenal ulcer increased with age. In patients under 60 years old, the prevalence of duodenal and gastric ulcers in females was markedly lower than that in males, especially the prevalence of duodenal ulcer. The prevalence of duodenal ulcer and gastric ulcer in H. pylori-infected patients was markedly higher than in patients without H. pylori infection. In the patients under 60 years old, sex differences were still seen in both H. pylori-positive and H. pylori-negative patients. The prevalence of gastric and duodenal ulcers was markedly increased with age in both H. pylori-positive and H. pylori-negative patients. Multivariate logistic regression analysis showed that age, male sex, and H. pylori infection were three independent risk factors for gastric and duodenal ulcers.

High prevalence of duodenal ulcer in a tertiary care hospital in the city of São Paulo, SP, Brazil

“…The risk of infected individuals to develop peptic ulcer was found to be 1.7 [95% CI = 1.17-2.47] which is similar to other reports that showed a relative risk of 1.6-5.7 (mean, 3.3) for infected people of developing peptic ulcer, compared with non-infected people (5) . Male gender [OR = 5.53; 95% CI = 3.67-8.34] and aging, as previously reported (26,28) , were also risks of peptic ulcer development. Within the peptic ulcer group, gastric ulcer group had significantly higher age; the incidence of gastric ulcer has been relatively higher in the elderly people, compared to that of duodenal ulcers (26) that may be due to lower defensive factors such as poor gastrin-elevating action capable of healing by its trophic effect (8) , decreased mucus, bicarbonate secretion and prostaglandins (12) .…”

Etiological factors of duodenal and gastric ulcers

“…Apart from Hp and NSAID, risk factors such as smoking, alcohol consumption, age, and male gender were reported as contributing to gastric and duodenal ulcer development (18)(19)(20)(21). In our study, patients who supported these findings were of middle or older age and 58% of them were male.…”

The Etiological Factors of Duodenal and Gastric Ulcers

“…Apart from H pylori and NSAID, risk factors such as smoking, alcohol intake, age, and male gender were reported as contributing to the gastric and duodenal ulcer development (17)(18)(19)(20). In our study, patients who are supporting these findings were at middle or older age and 58% of them were male.…”