Prevalence of pathologic gastroesophageal reflux in regurgitant infants

Costa, Adriano Carneiro da; Silva, Giselia A.P.; Gouveia, Pedro A. C.; Filho, Ernani M. Pereira

doi:10.2223/jped.1202

Cited by 12 publications

(6 citation statements)

References 21 publications

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“…The prevalence of regurgitation decreases with age, characterizing the benign course of the disorder contrary to GERD, where prevalence increases with age. 6 De and colleagues reported similar findings in their study. 7 In the present study male constitutes 60% and female constitutes 40% of children with GERD.…”

Section: Discussionsupporting

confidence: 78%

A cross-sectional study on prevalence of gastro esophageal reflux disease in regurgitant infant and children with evaluation of IGERQ score

Kandasamy

Andy

2018

Int J Contemp Pediatr

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Background: Gastro Esophageal Reflux Disease (GERD) is the most common esophageal disorder in children of all ages. GER becomes pathological when reflux increase in frequency and intensity, associated with esophageal and respiratory symptoms. Thus, the study was determined to assess the prevalence of GERD in regurgitant children of age 6 to 24 months with evaluation of IGERQ score (Infant Gastro Esophageal Reflux Questionnaire).Methods: A descriptive study was conducted in Gastroenterology Department, Institute of child Health and Hospital for Children, Egmore, Chennai from September 2007 to September 2009. 123 regurgitant children of age 6-24 months were enrolled. Clinical examination and validated questionnaire with total score of 25 was used. Data analysis was aided by EPI info programme. Chi square with P value <0.05 was considered statistically significant. IGERQ score was evaluated by calculating sensitivity, specificity, positive predictive valve and negative predictive valve.Results: The prevalence of GERD in regurgitant infant and children is 30.8%. Refusal of feeds and poor weight in regurgitant children significantly correlated with GERD. sensitivity was 84%, specificity was 96%, positive predictive value was 91%, negative predictive value was 93%Conclusions: Clinical diagnosis of GERD is sufficient in most instances and a questionnaire may aid in diagnosis the disease. IGERQ score is easily adaptable. IGERQ score >5 has high specificity positive and negative predictive value but reproducibility in our population need further evaluation.

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Section: Discussionsupporting

confidence: 78%

A cross-sectional study on prevalence of gastro esophageal reflux disease in regurgitant infant and children with evaluation of IGERQ score

Kandasamy

Andy

2018

Int J Contemp Pediatr

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“…GORD is the most common oesophageal disorder of children, affecting about 11% of all infants during their first year of life 12. It has been suggested that adult GORD may sometimes originate in childhood 3 13 – 16.…”

mentioning

confidence: 99%

Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus hernia

Åsling

Jirholt

Hammond

et al. 2009

Gut

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Background and objectives:Gastro-oesophageal reflux disease (GORD) is a common gastrointestinal disorder with a genetic component. Our aim was to identify genetic factors associated with GORD.Patients and methods:Four separate patient cohorts were analysed using a step-wise approach. (1) Whole genome linkage analysis was performed in 36 families. (2) Candidate genes were tested for GORD association in a trio cohort. (3) Genetic association was replicated in a case–control cohort. We also investigated genetic association to hiatus hernia (HH). (4) Protein expression was analysed in oesophageal biopsies.Results:A region on chromosome 2, containing collagen type III alpha 1 (COL3A1), was identified (LOD = 3.3) in families with dominant transmission of GORD, stratified for hiatus hernia (HH). COL3A1 showed significant association with GORD in an independent paediatric trio cohort (pcorr = 0.003). The association was male specific (pcorr = 0.018). The COL3A1 association was replicated in an independent adult case control cohort (pcorr = 0.022). Moreover, male specific association to HH (pcorr = 0.019) was found for a SNP not associated to GORD. Collagen type III protein was more abundant in oesophageal biopsies from male patients with GORD (p = 0.03).Conclusion:COL3A1 is a disease-associated gene in both paediatric and adult GORD. Furthermore, we show that COL3A1 is genetically associated with HH in adult males. The GORD- and HH-associated alleles are different, indicating two separate mechanisms leading to disease. Our data provides new insight into GORD aetiology, identifying a connective tissue component and indicating a tissue remodelling mechanism in GORD. Our results implicate gender differences in the genetic risk for both for GORD and HH.

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“…The age of onset of gastro‐esophageal reflux disease (GERD) is variable and many individuals develop the disease during childhood. Gastro‐esophageal reflux disease is the most common esophageal disorder of children, affecting about 11% of all infants during their first year of life 34 . Epidemiological data justify theory formation about a genetic component in the pathophysiology of GERD.…”

Section: Discussionmentioning

confidence: 99%

G-protein β3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese

Shimpuku

Futagami

Kawagoe

et al. 2011

Neurogastroenterology &Amp; Motility

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Prevalence of pathologic gastroesophageal reflux in regurgitant infants

Abstract: The prevalence of pathologic gastroesophageal reflux within the group of children examined concurred with previously published studies, with predominance, therefore, of regurgitant infants.

Cited by 12 publications

References 21 publications

A cross-sectional study on prevalence of gastro esophageal reflux disease in regurgitant infant and children with evaluation of IGERQ score

A cross-sectional study on prevalence of gastro esophageal reflux disease in regurgitant infant and children with evaluation of IGERQ score

Collagen type III alpha I is a gastro-oesophageal reflux disease susceptibility gene and a male risk factor for hiatus hernia

G-protein β3 subunit 825CC genotype is associated with postprandial distress syndrome with impaired gastric emptying and with the feeling of hunger in Japanese

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