Prevalence of Parkinsonism and Parkinson's disease in Qena governorate/Egypt: a cross-sectional community-based survey

Khedr, Eman M.; Fawi, Gharib; Abbas, Mohammed; Mohammed, Talal A.; El-Fetoh, Noha Abo; Attar, Ghada Al; Zaki, Ahmed

doi:10.1179/1743132815y.0000000020

Cited by 23 publications

(34 citation statements)

References 57 publications

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“…Parkinson's disease (PD) is the most common cause of Parkinsonism and is expected to affect about nine million patients by the year 2030 [1]. In a previous Egyptian study, the crude prevalence rate of PD was 548/10 5 inhabitants of the studied population [2].…”

Section: Introductionmentioning

confidence: 99%

Non-motor symptoms in newly diagnosed Parkinson’s disease patients

El-Heneedy

Bahnasy

2019

Egypt J Neurol Psychiatry Neurosurg

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Introduction: The non-motor symptoms (NMSs) in Parkinson's disease (PD) patients have greater effects on their quality of life compared to the motor symptoms; however, they are under-recognized. The aim: The study aims to evaluate the prevalence and severity of NMS in newly diagnosed PD patients in Tanta University hospitals. Patients and methods: The study included 41 newly diagnosed PD patients. All patients were screened for NMS by the non-motor symptoms questionnaire (NMS-Quest). According to the NMS-Quest response, patients were further evaluated by Sialorrhea Clinical Scale for PD (SCS-PD), Scales for Outcomes in Parkinson's disease for Autonomic symptoms (SCOPA-AUT), Rome III Questionnaire, Nocturnal voiding and Sleep-Interruptions Questionnaire, Brief Pain Inventory, Montreal Cognitive Assessment (MoCA), Scale for Evaluation of Neuropsychiatric Disorders in Parkinson's Disease (SEND-PD), Pittsburgh Sleep Quality Index (PSQI), and questionnaires based upon the International Restless Legs Study Group criteria. The results: The study included 22 female and 19 male patients; the duration of illness was 2.7 ± 2.08 years. Constipation was the most common symptoms as it was present in 73.1% in the studied patients; 61% suffered loss of sexual interest. 47.5% of patients had depressive symptoms. Sleep disturbance was present in 36.6% of the patients. Anxiety was reported by 30% of the patients. Conclusion: All newly diagnosed PD patients suffered one or more NMSs; constipation was the most frequent followed by sexual dysfunction, depressive symptoms, and sleep disturbance, while pain, sialorrhea, and restless leg were the least reported.

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Section: Introductionmentioning

confidence: 99%

Non-motor symptoms in newly diagnosed Parkinson’s disease patients

El-Heneedy

Bahnasy

2019

Egypt J Neurol Psychiatry Neurosurg

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“…There are accumulating evidences supporting the role of vitamin D deficiency in the pathogenesis of PD [2]. Long-standing low vitamin D levels may lead to chronic loss of dopaminergic neurons in the central nervous system and, as a consequence, the development of Parkinson's disease [26].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of PD increases with age; it affects 1% of the population over the age of 60 [1]. Compared to other Arab countries, the prevalence of PD disease is higher in Nile valley governorates of Upper Egypt [2]. Several epidemiologic studies have suggested an inverse relationship between circulating vitamin D levels and the risk of PD.…”

Section: Introductionmentioning

confidence: 99%

Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

Soliman

Oraby

Hussein

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Background: Multiple epidemiological data showed a significant higher prevalence of hypovitaminosis D in patients with Parkinson's disease (PD). Objectives: To assess the serum vitamin D level in patients with Parkinson's disease and to investigate the possible relationship between the serum vitamin D level and both motor and cognitive symptoms in Parkinson's disease Materials and methods: A case-control study was conducted on 25 patients who fulfilled the criteria for diagnosis of idiopathic Parkinson's disease based on the British Brain Bank criteria, and 25 healthy volunteers. Selected PD patients were submitted for assessment of cognitive function using the PD-Cognitive Rating Scale (PD-CRS) and assessment of motor function using the Unified Parkinson's Disease Rating Scale (UPDRS). Serum 25 hydroxy vitamin D level was measured for all the included patients and controls. Results: PD patients were found to have a significantly lower level of serum vitamin D than controls (P value = 0.001). There was a statistically significant negative correlation between the serum vitamin D level and the scores of motor, mentation, activities of daily living, medication complication, other complications, and the total score of UPDRS (P value = 0.01, < 0.001, 0.012, 0.017, 0.039, and 0.002 respectively). There was a statistically significant positive correlation between the serum vitamin D level and the scores of attention, working memory, immediate recall, delayed recall, naming, visuoperceptual abilities, visuoconstructional abilities, alternating verbal fluency, action verbal fluency, and the total score of PD-CRS (P value < 0.001 in all parameters). Conclusion: Vitamin D deficiency is evident in PD patient, and such deficiency significantly affected both motor and cognitive symptoms.

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“…However, studies having an average quality were included in this review due to the limited number of studies available and due to their valuable contributions to the field. There were eleven cross-sectional studies; four of these estimated the prevalence of Alzheimer's disease, Parkinson's disorder and mild cognitive impairment, and discussed the risks associated with sociodemographic factors; n=944 Palestinian, in addition to n=200 and n=44 Egyptian from two studies, and, n=221 Jordanian (Afgin et al, 2012;Esmayel, Eldarawy, Hassan, Mahmoud, & Mohamed, 2013;Khedr et al, 2015;Almomani, Almomani, Alghadir, Alharethy, & Gabr, 2016). A cross-sectional study in the Netherlands determined the prevalence of dementia and mild cognitive impairment across cultures, based on Arab participants (n=1625), and assessed the validity of the Cross-Cultural Dementia Screening tool .…”

Section: Main Termmentioning

confidence: 99%

Dementia in Eastern Mediterranean countries: A systematic review

2018

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Globally, there is an increase in the older population, whose lives are affected by local cultural norms. In Eastern Mediterranean countries, dementia is conventionally hidden from view with few dedicated services or recognition for diagnosis. The aim of this systematic review is to explore the limited literature on dementia and cognitive impairment among older people in Eastern Mediterranean countries to present an evaluation of current practices and to consolidate knowledge for future planning. Thirty-three studies were identified for inclusion in the review, and four themes were apparent. Firstly, prevalence, comorbidity and gender: In Eastern Mediterranean countries, many studies identify that the prevalence of dementia is high. As is the case elsewhere, many older adults in Eastern Mediterranean countries have at least one coexisting long-term condition, and some experience low life-satisfaction. Secondly, culture: In Eastern Mediterranean countries, the older adult is highly respected, and placement outside of the family home is considered an abandonment of family duty. The term dementia carries stigma, and it is widely believed that dementia is caused by 'fate'. Thirdly, recognition and tools: There is a lack of verified assessment instruments to assess for dementia. Despite concerns about the cultural appropriateness of the Mini-Mental State Exam, particularly for people who have low literacy levels, and low literacy being the norm in Eastern Mediterranean countries, the Mini-Mental State Examination is the main assessment instrument. Translation and transition of non-Arabic assessment instruments and tools with psychometric properties presents a challenge for clinicians. Finally, workforce issues: health care workers lack knowledge about dementia, as dementia care is a relatively recent addition to the nursing and medical syllabi. While there were some inconsistencies in the papers published, many of the articles call for increasing educational programmes and health and social care policies to promote improved and practical gerontological nursing and medicine. Health care professionals need education about sociocultural, religious, and language needs to deliver improved culturally sensitive care.

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Prevalence of Parkinsonism and Parkinson's disease in Qena governorate/Egypt: a cross-sectional community-based survey

Abstract: The overall prevalence of PD disease is high in Nile valley governorates of Upper Egypt compared to other Arabic countries.

Cited by 23 publications

References 57 publications

Non-motor symptoms in newly diagnosed Parkinson’s disease patients

Non-motor symptoms in newly diagnosed Parkinson’s disease patients

Could vitamin D deficiency have an impact on motor and cognitive function in Parkinson’s disease?

Dementia in Eastern Mediterranean countries: A systematic review

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