Prevalence of Overlaps between GERD, FD and IBS and Impact on Health-related Quality of Life

Psychological factors influence the overlap syndrome in functional gastrointestinal disorders and their effect on quality of life among firefighters in South Korea

“…43 A study conducted by Kaji et al also showed that overlap syndrome patients with FD and IBS had significantly lower QOL than healthy controls, suggesting that mental component was an important variable. 44 However, the finding by Mikocka-Walus et al differed from this research, and they reported that neither the number of FGID nor depression or anxiety influenced the QOL of overlap syndrome patients. 45 Therefore, it is necessary to conduct a further evaluation of the psychological factors affecting the QOL of overlap syndrome patients.…”

Functional dyspepsia impairs quality of life in the adult population

“…Our results are also in line with the results of Japanese and Korean studies showing a significant impact on HRQoL in physical and pain‐related SF‐36 domains. Both these studies did apply the Rome III definition of FD and the Korean study did also exclude organic reasons of FD by endoscopies but it was a case–control study and the Japanese study was not based on the general population, and gastrointestinal endoscopy was not included in the study protocol 16, 17 . Our study shows also that FD overlaps with both IBS and GERS, and the overlap impacts HRQoL.…”

“…In a population‐based, nested, case–control study, subjects reporting symptoms of either dyspepsia or irritable bowel syndrome and healthy controls were interviewed and completed questionnaires on psychological measures plus the validated Short Form‐36 questionnaire (SF‐36); an association between lower mental HRQoL and dyspepsia was found after adjusting for psychological covariates, but FD was not confirmed by endoscopy 15 . There are two recently published studies from Asia applying the Rome III definition of functional dyspepsia and focusing on the impact of overlapping FD‐irritable bowel syndrome (FD‐IBS) and FD‐gastro‐oesophageal reflux symptoms (FD‐GERS) on HRQoL 16, 17 . In the Japanese study FD had a significant impact on HRQoL in all physical and psychological domains of the Short Form‐8 questionnaire and overlap with IBS and GERS was associated with significantly worsened HRQoL and the Korean study concluded that overlapping FD‐IBS had more impact on HRQoL than FD or IBS alone had 16, 17 …”

“…There are two recently published studies from Asia applying the Rome III definition of functional dyspepsia and focusing on the impact of overlapping FD‐irritable bowel syndrome (FD‐IBS) and FD‐gastro‐oesophageal reflux symptoms (FD‐GERS) on HRQoL 16, 17 . In the Japanese study FD had a significant impact on HRQoL in all physical and psychological domains of the Short Form‐8 questionnaire and overlap with IBS and GERS was associated with significantly worsened HRQoL and the Korean study concluded that overlapping FD‐IBS had more impact on HRQoL than FD or IBS alone had 16, 17 …”

The association between body mass index and gastroesophageal reflux disease in the World Trade Center Health Program General Responder Cohort

“…GERD is characterized by symptoms of heartburn, chest pain, and dysphagia, and has been associated with a poorer quality of life [Kaji et al, ; Milani et al, ]. Higher body mass index (BMI) has been associated with an increased risk of developing GERD.…”